A5035132045- COVID-19 Clinical Research Studies
- Hemoglobinopathies and Related Disorders
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Iron Metabolism and Disorders
- Blood transfusion and management
- Blood groups and transfusion
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood donation and transfusion practices
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- GDF15 and Related Biomarkers
- Immune Cell Function and Interaction
- Pregnancy and preeclampsia studies
- Venous Thromboembolism Diagnosis and Management
- Platelet Disorders and Treatments
- Sepsis Diagnosis and Treatment
- SARS-CoV-2 detection and testing
- Neonatal Respiratory Health Research
- Blood Coagulation and Thrombosis Mechanisms
- Heparin-Induced Thrombocytopenia and Thrombosis
- T-cell and B-cell Immunology
- Erythrocyte Function and Pathophysiology
- Neonatal Health and Biochemistry
- Immunotherapy and Immune Responses
- Renal Diseases and Glomerulopathies
National and Kapodistrian University of Athens
2016-2025
Aretaeio Hospital
2011-2025
Laiko General Hospital of Athens
2024
Alexandra Hospital
2020-2021
Hippocration General Hospital
2019
Panteion University
2012
University General Hospital Attikon
2009
Hammersmith Hospital
2004-2006
Imperial College London
2004-2006
Zero to Three
2006
There is an unmet need of models for early prediction morbidity and mortality Coronavirus disease-19 (COVID-19). We aimed to a) identify complement-related genetic variants associated with the clinical outcomes ICU hospitalization death, b) develop artificial neural network (ANN) predicting these c) validate whether are impaired complement phenotype. prospectively recruited consecutive adult patients Caucasian origin, hospitalized due COVID-19. Through targeted next-generation sequencing, we...
Dickkopf-1 (DKK-1) protein, a soluble inhibitor of Wnt signalling, has been implicated in the pathogenesis myeloma bone disease through suppression osteoblast differentiation. In this study, serum concentrations DKK-1 were measured 50 patients (32 at diagnosis and 18 before after autologous stem cell transplantation (ASCT), with monoclonal gammopathy undetermined significance (MGUS), 22 healthy controls. Serum levels increased MM compared MGUS (mean +/- SD: 67 54 ng/mL vs. 38 13 ng/mL; p =...
We evaluated the antibody responses in 259 potential convalescent plasma donors for Covid-19 patients. Different assays were used: a commercial ELISA detecting antibodies against recombinant spike protein (S1); multiplex assay total and specific isotypes three SARS-CoV-2 antigens (S1, basic nucleocapsid (N) receptor-binding domain (RBD)); an in-house to complete spike, RBD N 60 of these donors. Neutralizing (NAb) also Analyzed samples collected at median time 62 (14–104) days from day first...
Abstract There is a plethora of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) serological tests based either on nucleocapsid phosphoprotein (N), S1-subunit spike glycoprotein (S1) or receptor binding domain (RBD). Although these single-antigen demonstrate high clinical performance, there growing evidence regarding their limitations in epidemiological serosurveys. To address this, we developed Luminex-based multiplex immunoassay that detects total antibodies (IgG/IgM/IgA)...
Background: The platelet functionality of cold-stored platelets remains a subject debate. Our aim was to investigate the effect temperature on hemostatic properties stored platelets. Methods: Ten split pooled at cold and room were evaluated in vitro storage days 1, 5, 10, 15 for metabolic, physiological, vesiculation parameters, as well their profile using rotational thromboelastometry (ROTEM®). Results: integrity better preserved platelets, lower lactate dehydrogenase levels documented...
<h3>Background</h3> The direct antiglobulin test (DAT) is the cornerstone of diagnosis hemolytic disease newborn (HDN). aim this study was to review incidence and causes positive DAT in cord blood relation development HDN. <h3>Methods</h3> We retrospectively reviewed all results DAT, which routinely performed samples, along with laboratory infants' medical records. <h3>Results</h3> 70/2695 (2.59%) cases. In 64/70 (91.43%) cases, positivity attributed ABO incompatibility. There were 50/218...
Abstract The aim of the study was to develop and validate a prediction model for hemorrhage in critically ill neonates which combines rotational thromboelastometry (ROTEM) parameters clinical variables. This cohort included 332 consecutive full-term preterm neonates. We performed ROTEM used neonatal bleeding assessment tool (NeoBAT) record events. fitted double selection least absolute shrinkage operator logit regression build our model. Bleeding within 24 hours testing outcome variable,...
Immune profiling of patients with COVID-19 has shown that SARS-CoV-2 causes severe lymphocyte deficiencies (e.g., lymphopenia, decreased numbers, and exhaustion T cells) increased levels pro-inflammatory monocytes. Peripheral blood (PB) samples from convalescent plasma (CP) donors, patients, control subjects were analyzed by multiparametric flow cytometry, allowing the identification a wide panel immune cells, comprising lymphocytes (T, B, natural killer (NK) NKT cells), monocytes,...
It is unclear whether the ChAdOx1 nCov-19 vaccine can induce development of anti-PF4 antibodies in vaccinated individuals who have not developed thrombosis. The aim this prospective study was to evaluate presence against heparin/PF4 adults received a first dose vaccine, and correlate them with clinical data antibody responses vaccine. We detected non-platelet activating 67% (29/43) on day 22 following though these were low titers. Furthermore, there no correlation between IgG baseline...
Lenalidomide has significant antimyeloma activity but it is associated with a risk of venous thromboembolism (VTE). In this study, we assessed clinical and genetic factors that may predispose for VTE in myeloma patients who were treated lenalidomide-based regimens. We analyzed common selected 200 consecutive, unselected regimens single institution. Twelve (6%) developed (nine deep thrombosis three pulmonary embolism). All VTEs occurred receiving aspirin prophylaxis; no patient received LMWH...
Background. The objective of our study is to investigate the potential effect adjusting preoperative platelet lymphocyte ratio, an emerging biomarker survival in cancer patients, for fraction large platelets. Methods. A total 79 patients with breast neoplasias, 44 fibroadenomas, and 35 invasive ductal carcinoma were included study. Both conventional ratio (PLR) adjusted marker, (LPLR), correlated laboratory histopathological parameters sample. Results. LPLR elevation was significantly...
Endothelial injury indices, such as Activation and Stress Index (EASIX), modified EASIX (m-EASIX), simplified (s-EASIX) scores, have been previously associated with chimeric antigen receptor-T (CAR-T) cell immunotherapy complications. Soluble urokinase-type plasminogen activator receptor (suPAR), growth differentiation factor-15 (GDF-15), soluble C5b-9 (sC5b-9) described markers of endothelial post-hematopoietic stem transplantation. In the current study, we examined whether suPAR, GDF-15,...
HEV infection is an emerging public health problem worldwide Data concerning in HIV+ patients Greece scare. The aim of the study was to determine seroprevalence with HIV Greece. We studied 243 HIV(+) 214 men (88%) and 29 women (12%) a median age 45 years (range 19–83) who attended unit Pathophysiology Department Laikon General Hospital Athens for presence anti-HEV IgG antibodies (EIA) (EIA IgG, Adaltis, Rome, Italy Eighteen/243 (7.3%) were positive antibodies, that not different from...