A5049880803- Forensic Toxicology and Drug Analysis
- Renal and Vascular Pathologies
- Clinical Laboratory Practices and Quality Control
- Blood groups and transfusion
- Thyroid Disorders and Treatments
- Hormonal and reproductive studies
- Metabolomics and Mass Spectrometry Studies
- Blood Pressure and Hypertension Studies
- Pesticide Residue Analysis and Safety
- Platelet Disorders and Treatments
- Cardiac Arrhythmias and Treatments
- Advanced MRI Techniques and Applications
- Statistical Methods in Clinical Trials
- Heart Rate Variability and Autonomic Control
- Radiology practices and education
- Blood Coagulation and Thrombosis Mechanisms
- Vascular anomalies and interventions
- Artificial Intelligence in Healthcare
- Analytical Methods in Pharmaceuticals
- Muscle and Compartmental Disorders
- Veterinary Practice and Education Studies
- Blood properties and coagulation
- Complement system in diseases
- Vitamin D Research Studies
- Artificial Intelligence in Healthcare and Education
National and Kapodistrian University of Athens
2024
Westmead Hospital
2005-2024
The University of Sydney
2018-2022
New South Wales Department of Health
2018-2022
Macquarie University
2020
GTx (United States)
2012
Although short activated partial thromboplastin times (APTTs) are generally considered to be laboratory artefacts of problematic blood collections, there is mounting evidence that in some cases a APTT may reflect hypercoagulable state, potentially associated with increased thrombotic risk and adverse cardiovascular events. We prospectively evaluated the phenomenon APTTs 113 consecutive samples compared an equal number age sex-matched normal samples. found significant difference various test...
Short activated partial thromboplastin times (APTTs) are associated with thrombosis. However, what short APTTs actually represent in terms of possible mechanistic pathways is not well characterized. We have assessed thrombin generation as compared levels procoagulant factor (fibrinogen, V, VIII, IX, XI and XII) activities, von Willebrand level activity using collagen binding, phospholipid activity, 113 consecutive samples exhibiting a APTT an equal number age-matched sex-matched yielding...
Summary Deficiency of or defects in the plasma protein von Willebrand factor (VWF) lead to bleeding and disease (VWD), which may be congenital acquired. VWD is considered most common inherited disorder laboratory testing for VWF level activity critical appropriate diagnosis management. We have designed established a novel Flow Cytometry (FC) based method measuring antigen (VWF:Ag) collagen binding (VWF:CB), together same tube at time. The results FC been compared against existing reference...
Clinical studies of transcatheter radiofrequency renal denervation for treating hypertension have been hampered by the lack consistent efficacy. We aimed to demonstrate short-term efficacy and safety microwave denervation.A novel 7F system was validated in a sheep model unilateral denervation. Up two ablations were delivered each artery with maximum power at 100-110 W 480 s.Catheter deployment ablation successful all 19 targeted vessel segments, produced substantial circumferential...
Transcatheter renal denervation (RDN) has had inconsistent efficacy and concerns for durability of denervation. We aimed to investigate long-term safety transcatheter microwave RDN in vivo normotensive sheep comparison conventional radiofrequency ablation.
Iodine deficiency disorders (IDD) result from inadequate thyroid hormone production due to iodine intake. It is estimated that 2 billion individuals worldwide have insufficient the most common cause of preventable mental impairment worldwide. The usually recommended strategy control through universal salt iodization and more recently fortification flour. Introduction iodized regions chronic iodine-deficiency might transiently increase proportion excess, but overall small risks excess are far...
A new quality control model using performance goals based on biological variation in External Quality Assurance Schemes (EQAS) is described. The proposed aims to use assay (analytical) CV(A), bias and total error available from participation EQAS describe minimum, desirable optimum specifications variation. provides further analysis of data should be useful better management laboratory control, as it information that can facilitate trouble-shooting. Additionally, help evaluating the current...
Abstract In response to increasingly complex demands in terms of productivity and budgets, there is a critical need avoid mistakes during instrument selection that will be financially costly, adversely affect customers, staff, test turnaround time. As no “one size fits all”, guidelines must appropriate permit informed decision making. A Medline search was conducted assess background knowledge this area, using the “laboratory selection” evaluation”. Searches returned over 800 articles, which...
Iodine deficiency remains a public health concern, particularly in pregnant women and those planning pregnancy because of the risk impaired fetal neurological development. Following implementation strategies to improve iodine intake Australia, there has been minimal investigation into current status. We aimed characterise status population childbearing-age Australia.A cross-sectional study was performed 97 attending outpatient clinics at tertiary hospital Sydney. Pregnant postmenopausal were...
Resumen Objetivos Este artículo aborda los aspectos clave e impacto de aplicar el big data y la inteligencia artificial para optimizar modelos detección temprana, diagnóstico preciso rápido, manejo pacientes, tratamientos, medicina precisión, distribución recursos. Contenido Los procesos incluyen aprendizaje automático, razonamiento basado en unas reglas obtener conclusiones aproximadas o definitivas, autocorrección. Estos mejorarían enfermedades, enfermedades raras, toxicidades,...
<h3>Background:</h3> Sjögren's disease (SjD) is a systemic autoimmune disorder that primarily affects the exocrine glands, particularly salivary and lacrimal glands. Recent efforts have exploited serum saliva metabolome analysis to enhance our understanding of pathogenetic mechanisms development novel biomarkers, however these studies are hampered by limited patient numbers, poorly characterized SjD cases, absence proper control groups, lack clinicohistologic associations, variations in...
Abstract Background Clinical studies of transcatheter radiofrequency renal denervation for treating hypertension have been hampered by the lack consistent efficacy. Microwave energy is well suited to due its capacity spare vascular structures cooling from adjacent blood flow while enabling deep perivascular heating. Purpose We aimed to: 1) develop a microwave system capable safely delivering and circumferential nerve ablation, 2) demonstrate feasibility, short-term efficacy safety...
he upper western sector of Far West Area HealthService (FWAHS) spans approximately 120,000km some the most rugged and remote landin New South Wales, Australia, includes thetowns Bourke, Brewarrina, Walgett, Collarene-bri, Lightning Ridge, other smaller commu-nities. largest town, is located 780km north-west Sydney, has a population approximately4,500 at least 4 hours away from city Dubbo, thenearest regional centre. The difficulties for medical staff workingin these regions are geographic...
Background: Measurement Uncertainty (MU) can assist the interpretation and comparison of laboratory results against international diagnostic protocols, facilitate a reduction in health care costs also help protect laboratories legal challenges. Determination MU for quantitative testing clinical pathology is requirement ISO 15189. Methods: A practical simple to use statistical model has been designed make data readily available assess establish assays based on internal quality control...