A5042316856- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Optical Coherence Tomography Applications
- Optical Imaging and Spectroscopy Techniques
- Retinal Diseases and Treatments
- Visual perception and processing mechanisms
- Photoacoustic and Ultrasonic Imaging
- Optical Polarization and Ellipsometry
- Ocular Surface and Contact Lens
- Gaze Tracking and Assistive Technology
- Collagen: Extraction and Characterization
- Retinal Imaging and Analysis
- Ocular and Laser Science Research
- Neural dynamics and brain function
- Tactile and Sensory Interactions
- Advanced Fluorescence Microscopy Techniques
- Optical measurement and interference techniques
- Ultrasonics and Acoustic Wave Propagation
- Ultrasound Imaging and Elastography
- Advanced MEMS and NEMS Technologies
- Advanced Fiber Optic Sensors
- Ophthalmology and Eye Disorders
- Piezoelectric Actuators and Control
- Virtual Reality Applications and Impacts
- Advanced Optical Imaging Technologies
University of Rochester
2020-2024
Second Affiliated Hospital of Zhejiang University
2022-2024
Center for Visual Communication (United States)
2022-2024
McGill University
2024
Duquesne University
2020-2023
People's Hospital of Yangzhong
2023
Zigong First People's Hospital
2021-2023
University of Pittsburgh
2017-2022
Second Affiliated Hospital of Nanjing Medical University
2022
Nanjing Medical University
2022
BackgroundDeep learning has been widely used for glaucoma diagnosis. However, there is no clinically validated algorithm incidence and progression prediction. This study aims to develop a feasible deep-learning system predicting stratifying the risk of onset based on color fundus photographs (CFPs), with clinical validation performance in external population cohorts.MethodsWe established data sets CFPs visual fields collected from longitudinal cohorts. The mean follow-up duration was 3 5...
Collagen fibers play a central role in normal eye mechanics and pathology. In ocular tissues, collagen exhibit complex 3-dimensional (3D) fiber orientation, with both in-plane (IP) out-of-plane (OP) orientations. Imaging techniques traditionally applied to the study of tissues only quantify IP providing little information on OP orientation. Accurate description 3D microstructures requires quantifying full Herein, we present 3dPLM, technique based polarized light microscopy developed...
The measurement of soft tissue fiber orientation is fundamental to pathophysiology and biomechanical function in a multitude biomedical applications. However, many existing techniques for quantifying structure rely on transmitted light, limiting general applicability often requiring processing. Herein, we present novel wide-field reflectance-based imaging modality, which combines polarized light (PLI) spatial frequency domain (SFDI) rapidly quantify preferred collagenous tissues. PLI...
Early screening for syphilis among pregnant women and the effective treatment of maternal is fundamental to prevent congenital (CS).We obtained data from Shenzhen Program Prevention CS (SPPCS) estimated incidence rates infants born syphilis-seropositive treated with different regimens or untreated syphilis.A total 4746 matched cases mothers their were included analyses, 162 diagnosed CS, providing an overall 3.41% (95% confidence interval [CI], 2.91%-3.98%). Among who had adequately before...
Purpose: The purpose of this study was to determine the longitudinal changes in macular retinal and choroidal microvasculature normal healthy highly myopic eyes. Methods: Seventy-one eyes, including 32 eyes with high myopia 39 control followed for at least 12 months examined using optical coherence tomography angiography imaging 3 visits, were included study. Fovea-centered 6 × mm scans performed measure capillary density (CD) superficial plexus (SCP), deep (DCP), choriocapillaris (CC)....
Collagen is a major constituent of the eye and understanding its architecture biomechanics critical to preserve restore vision. We, recently, demonstrated polarized light microscopy (PLM) as powerful technique for measuring properties collagen fibers eye, such spatial distribution orientation. Our implementation PLM, however, required sectioning tissues imaging using transmitted light. This problematic because it limits analysis thin sections. not only slow, but precludes study dynamic...
Collagen fibers are a primary load-bearing component of connective tissues and therefore central to tissue biomechanics pathophysiology. Understanding collagen architecture behavior under dynamic loading requires quantitative imaging technique with simultaneously high spatial temporal resolutions. Suitable techniques thus rare often inaccessible. In this study, we present instant polarized light microscopy (IPOL), in which single snapshot image encodes information on fiber orientation...
We demonstrate a MEMS micromirror enabled handheld confocal imaging probe for portable oral cancer detection, where comparatively large field of view (FOV) was generated through the programmable Lissajous scanning pattern micromirror. Miniaturized developed, and further compared with desktop prototype under clinical setting. For system, optical design simulations using CODE VR® shows lateral axial resolution to be 0.98 µm 4.2 µm, experimental values were determined 3 5.8 respectively, FOV...
The purpose of this study was to visualize the lamina cribrosa (LC) capillaries and collagenous beams, measure capillary tortuosity (path length over straight end-to-end length), determine if changes when intraocular pressure (IOP) increases.Within 8 hours sacrifice, 3 pig heads were cannulated via external ophthalmic artery, perfused with PBS remove blood, then a fluorescent dye label capillaries. posterior pole each eye mounted in custom-made inflation chamber for control IOP simultaneous...
Purpose: To evaluate the frequency of and identify factors that influence artifacts swept-source optical coherence tomography angiography (SS-OCTA) in glaucomatous normal eyes. Methods: Artifacts OCTA images open-angle glaucoma (OAG) subjects were analyzed using SS-OCTA. Univariate multivariate logistic regression analyses performed to association age, sex, best-corrected visual acuity, axial length (AL), intraocular pressure, presence severity OAG, image quality score (IQS) with artifacts....
Our group previously introduced Polarized Spatial Frequency Domain Imaging (PSFDI), a wide-field, reflectance imaging technique which we used to empirically map fiber direction in porcine pulmonary heart valve leaflets (PHVL) without optical clearing or physical sectioning of the sample. Presented is an extended analysis our PSFDI results using inverse Mueller matrix model polarized light scattering that allows additional maps orientation distribution, along with instrumentation permitting...
Though virtual reality (VR) has been advanced to certain levels of maturity in recent years, the general public, especially population blind and visually impaired (BVI), still cannot enjoy benefit provided by VR. Current VR accessibility applications have developed either on expensive head-mounted displays or with extra accessories mechanisms, which are not accessible inconvenient for BVI individuals. In this paper, we present a mobile app that enables users access environment an iPhone...
This study was targeted at investigating the biological functions of E74-like ETS transcription factor 1 (ELF1) in pancreatic cancer (PC) and its underlying mechanism.ELF1 expression PC tissues detected by quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR) immunohistochemistry. Cell counting kit-8 (CCK-8) method, EdU method flow cytometry were used to detect cell proliferation apoptosis lines after transfection.A subcutaneous tumorigenesis model constructed...
Elevated intraocular pressure (IOP) deforms the lamina cribrosa (LC), a structure within optic nerve head (ONH) in back of eye. Evidence suggests that these deformations trigger events eventually cause irreversible blindness, and have therefore been studied in-vivo using optical coherence tomography (OCT), ex-vivo OCT diversity techniques. To best our knowledge, there no in-situ studies LC mechanics. Our goal was two-fold: to introduce technique for measuring 3D from OCT, determine whether...