Ariana Plasger
A5038560547- Amino Acid Enzymes and Metabolism
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Lung Cancer Research Studies
- Innovations in Medical Education
- Uterine Myomas and Treatments
- Fibroblast Growth Factor Research
- Neuroendocrine Tumor Research Advances
- Anatomy and Medical Technology
- Surgical Simulation and Training
- Cancer-related gene regulation
- RNA modifications and cancer
- Endometrial and Cervical Cancer Treatments
- Endometriosis Research and Treatment
University Hospital Münster
2020-2024
Cornell University
2020-2021
Weill Cornell Medicine
2020
A hallmark of metastasis is the adaptation tumor cells to new environments. Metabolic constraints imposed by serine and glycine-limited brain environment restrict metastatic growth. How metastases overcome these growth-prohibitive conditions poorly understood. Here, we demonstrate that 3-phosphoglycerate dehydrogenase (PHGDH), which catalyzes rate-limiting step glucose-derived synthesis, a major determinant in multiple human cancer types preclinical models. Enhanced synthesis proved...
Abstract Introduction Adenomyosis is a special subtype of endometriosis, affecting the myometrium, about 20% women in reproductive age period. Clinical symptoms and intensity are diverse can vary from heavy menstrual bleeding dysmenorrhea to infertility repeated pregnancy losses. Thus, patients often present with long history illness pending presumptive clinical or surgical diagnosis. A definitive diagnosis adenomyosis made upon histopathological examination verifying ectopic endometrial...
Abstract A hallmark of metastasis is the adaptation tumor cells to new environments. Although it well established that metabolic milieu brain severely deprived nutrients, particularly amino acids serine and its catabolite glycine, how metastases rewire their metabolism survive in nutrient-limited environment poorly understood. Here we demonstrate cell-intrinsic de novo synthesis a major determinant metastasis. Whole proteome comparison triple-negative breast cancer (TNBC) differ capacity...
Abstract The metabolic milieu of the brain is severely deprived nutrients, including amino acids serine and its catabolite glycine. rewiring required for tumor cells to survive in nutrient-limited environment vulnerabilities this confers are poorly understood. Here we demonstrate that cell-intrinsic de novo synthesis a major determinant triple-negative breast cancer (TNBC) metastasis. Whole proteome comparison TNBC differ their capacity colonize reveals 3-phosphoglycerate dehydrogenase...
<div>Abstract<p>A hallmark of metastasis is the adaptation tumor cells to new environments. Metabolic constraints imposed by serine and glycine–limited brain environment restrict metastatic growth. How metastases overcome these growth-prohibitive conditions poorly understood. Here, we demonstrate that 3-phosphoglycerate dehydrogenase (PHGDH), which catalyzes rate-limiting step glucose-derived synthesis, a major determinant in multiple human cancer types preclinical models....
<div>Abstract<p>A hallmark of metastasis is the adaptation tumor cells to new environments. Metabolic constraints imposed by serine and glycine–limited brain environment restrict metastatic growth. How metastases overcome these growth-prohibitive conditions poorly understood. Here, we demonstrate that 3-phosphoglycerate dehydrogenase (PHGDH), which catalyzes rate-limiting step glucose-derived synthesis, a major determinant in multiple human cancer types preclinical models....
Abstract The brain environment is low in amino acids, including serine and glycine, both of which are important for tumor growth as they precursors proteins nucleotide bases. How cells overcome these conditions to proliferate survive the incompletely understood. Here, we show that 3-phosphoglycerate dehydrogenase (PHGDH), catalyzes first rate-limiting step glucose-derived synthesis, enables metastasis multiple human types preclinical models. Genetic suppression small molecule inhibition...