A5021852568- Zebrafish Biomedical Research Applications
- Retinal Development and Disorders
- Behavioral Health and Interventions
- Visual perception and processing mechanisms
- Glaucoma and retinal disorders
- Bullying, Victimization, and Aggression
- Animal Behavior and Reproduction
- Marine animal studies overview
- Fish Ecology and Management Studies
- Ocular and Laser Science Research
- Circadian rhythm and melatonin
- Animal Vocal Communication and Behavior
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Congenital heart defects research
- Neurobiology and Insect Physiology Research
- Underwater Vehicles and Communication Systems
- Water Quality Monitoring Technologies
- Advanced Chemical Sensor Technologies
- Physiological and biochemical adaptations
- Stress Responses and Cortisol
- Neurological Complications and Syndromes
- Plant and Biological Electrophysiology Studies
- Pain Management and Placebo Effect
- Bat Biology and Ecology Studies
Einstein Center for Neurosciences Berlin
2024
Charité - Universitätsmedizin Berlin
2024
Champalimaud Foundation
2020-2024
Max Planck Institute for Medical Research
2013-2016
Max Planck Society
2013-2015
University Medical Centre Mannheim
2015
Heidelberg University
2015
Augenklinik Heidelberg
1980-1981
Max Planck Institute for Heart and Lung Research
1980
Motion is the basis of nearly all animal behavior. Evolution has led to some extraordinary specializations propulsion mechanisms among invertebrates, including mandibles dracula ant and claw pistol shrimp. In contrast, vertebrate skeletal movement considered be limited by speed muscle, saturating around 250 Hz. Here, we describe unique mechanism which
The stress response is a suite of physiological and behavioral processes that help to maintain or reestablish homeostasis. hypothalamic-pituitary-adrenal (HPA) axis central the response, as it releases crucial hormones in stress. Glucocorticoids (GCs) are final effector HPA exert variety actions under both basal conditions. Despite their far-reaching importance for health, specific GC effects have been difficult pin-down due lack methods selectively manipulating endogenous levels. To study...
Secondary hyperalgesia is believed to be a key feature of "central sensitization" and characterized by enhanced pain mechanical nociceptive stimuli. The aim the present study was characterize, using EEG, effects pinprick stimulation intensity on magnitude pinprick-elicited brain potentials [event-related (ERPs)] before after secondary induced intradermal capsaicin in humans. Pinprick-elicited ERPs pinprick-evoked ratings were recorded 19 healthy volunteers, with stimuli varying intensities...
ABSTRACT Acoustic signalling, integral to intraspecific communication and reproductive behaviour, undergoes notable changes during an animal's ontogenetic development. The onset progression of this maturation in fish remains poorly understood. Here, we investigated the ontogeny acoustic miniature teleost Danionella cerebrum, one smallest known vertebrates emerging model organism. Its adult males produce audible clicks that appear sequences with a repetition rate ∼60 or ∼120 Hz, caused by...
The anterior pituitary is the major link between nervous and hormonal systems, which allow brain to generate adequate flexible behaviour. Here, we address its role in mediating behavioural adjustments that aid coping with acutely threatening environments. For this combine optogenetic manipulation of corticotroph cells larval zebrafish newly developed assays for measuring goal-directed actions very short timescales. Our results reveal modulatory cell activity on locomotion, avoidance...
The relationship between stress and food consumption has been well documented in adults but less so developing vertebrates. Here we demonstrate that an encounter with a stressor can suppress larval zebrafish. Furthermore, provide indication intake suppression cannot be accounted for by changes locomotion, oxygen visual responses, as they remain unaffected after exposure to potent stressor. We also show feeding reoccurs when basal levels of cortisol (stress hormone humans teleosts) are...
Animals constantly integrate sensory information with prior experience to select behavioral responses appropriate the current situation. Genetic factors supporting this flexibility are often disrupted in neuropsychiatric conditions, such as autism-linked
Larval zebrafish (Danio rerio) have become favored subjects for studying the neural bases of behavior. Here, we report a highly stereotyped response larvae to hydrodynamic stimuli. It involves positive taxis, motion damping and sustained responsiveness flows derived from local, non-stressful water motions. The depends on lateral line has high sensitivity stimulus frequency strength, sensory background rearing conditions - also encompassing increased threshold levels parallel input. results...
Abstract Acoustic signaling, integral to intraspecific communication and reproductive behavior, undergoes notable changes during an animal’s ontogenetic development. The onset progression of this maturation in fish remains poorly understood. Here, we investigate the ontogeny acoustic micro glassfish Danionella cerebrum (DC), one smallest known vertebrates emerging model organism neuroscience. Adult DC males produce audible clicks that appear sequences with a repetition rate 60 or 120 Hz,...
Summary Social experiences greatly define successive social behavior. Lack of such experiences, especially during critical phases development, can severely impede the ability to behave adequately in contexts. To date it is not well characterized how early-life isolation leads deficits and impacts development. In many model species, challenging fully control because they depend on parental care. Moreover, complex behaviors involve multiple sensory modalities, contexts, actions. Hence, when...
Visual evoked cortical potential (VECP) to non-structured, brightness (luminance) stimuli do not provide an appropriate means for assessing the degree of impaired central vision. In comparison, visually potentials structured (patterned) presented by pattern reversal equal mean luminance are highly susceptible visual changes caused reduced Employing different check sizes, use checkerboard VECPs permits, independently patient, assess impairment
ABSTRACT Animals constantly perceive and integrate information across sensory modalities, their nervous systems must select behavioral responses appropriate to the current situation prior experience. Genetic factors supporting this flexibility are often disrupted in neuropsychiatric conditions, our previous work revealed disease-associated ap2s1 gene critically supports habituation learning acoustically-evoked escape behavior of zebrafish. encodes a subunit AP2 endocytosis adaptor complex...
Animals constantly perceive and integrate information across sensory modalities, their nervous systems must select behavioral responses appropriate to the current situation prior experience. Genetic factors supporting this flexibility are often disrupted in neuropsychiatric conditions, our previous work revealed disease-associated ap2s1 gene critically supports habituation learning acousticallyevoked escape behavior of zebrafish. encodes a subunit AP2 endocytosis adaptor complex has been...