A5067744768- Effects of Radiation Exposure
- Connexins and lens biology
- Food composition and properties
- Radiation Dose and Imaging
- Glutathione Transferases and Polymorphisms
- Meat and Animal Product Quality
- Radiation Therapy and Dosimetry
- Sensory Analysis and Statistical Methods
- Microbial Metabolites in Food Biotechnology
- Protein Hydrolysis and Bioactive Peptides
- Carcinogens and Genotoxicity Assessment
- Seed and Plant Biochemistry
- Proteins in Food Systems
- Consumer Attitudes and Food Labeling
University of Reading
2024
UK Health Security Agency
2023
Public Health England
2019-2021
Introduction Oat-based milk alternatives (OMAs) have become increasingly popular, perhaps due to their low allergenicity and preferred sensory attributes when compared other alternatives. They may also provide health benefits from unique compounds; avenanthramides, avenacosides, the dietary fibre beta-glucan. This has led a variety of commercial options becoming available. Being fairly new product, in comparison plant-based (PBMAs), means little research been undertaken on profile, how it is...
The influence of dose rate on radiation cataractogenesis has yet to be extensively studied. One recent epidemiological investigation suggested that protracted exposure increases radiation-induced cataract risk: cumulative doses mostly <100 mGy received by US radiologic technologists over 5 years were associated with an increased excess hazard ratio for development. However, there are few mechanistic studies support and explain such observations. Low-dose DNA damage in the epithelial cells...
Oat-based milk alternatives (OMAs) are an important alternative to bovine milk, with prevalence of lactose intolerance, as well soy and nut allergies limiting consumers options. However, OMAs typically lower in protein content than both soy-based alternatives, quality limited by low lysine levels, which can reduce digestibility. Addition plant proteins may increase the quantity protein, balancing amino acid profile. plant-based have additional sensory qualities off-flavours, lead undesirable...
Lens epithelial cell proliferation and differentiation are naturally well regulated controlled, a characteristic essential for lens structure, symmetry function. The effect of ionizing radiation on has been demonstrated in previous studies at high acute doses, but the dose rate not yet considered. In this work, mice received single doses 0.5, 1 2 Gy radiation, rates 0.063 0.3 Gy/min. Eye lenses were isolated postirradiation 30 min up until 14 days flat-mounted. Then, determined using...
Epidemiological studies suggest an increased incidence and risk of cataract after low-dose (<2 Gy) ionizing radiation exposures. However, the biological mechanism(s) this process are not fully understood. DNA damage repair thought to have a contributing role in radiation-induced cataractogenesis. Recently we reported inverse dose-rate effect, as well response, lens epithelial cells (LECs). Here, present further initial findings from two mutated strains (Ercc2+/– Ptch1+/–) mice, both...
Recent epidemiological findings and reanalysis of historical data suggest lens opacities resulting from ionizing radiation exposures are likely induced at lower doses than previously thought. These observations have led to ICRP recommendations for a reduction in the occupational dose limits eye lens, as well subsequent implementation EU member states. The CONCERT LDLensRad project was initiated further understand effects on identify mechanism(s) involved radiation-induced cataract, impact...
Ionizing radiation (IR) is a risk factor for acute myeloid leukemia (rAML). Murine rAMLs feature both hemizygous chromosome 2 deletions (Del2) and point mutations (R235) within the hematopoietic regulatory gene Spi1. We generated heterozygous CBA Spi1 R235 mouse (CBASpm/+) which develops de novo AML with 100% incidence by ∼12 months old shows dose-dependent reduction in latency following X-irradiation. These effects are reduced on an AML-resistant C57Bl6 genetic background. CBASpm/Gfp...
Background: Oat-based Milk Alternatives (OMAs) provide multiple health benefits arising from oat's unique compounds: avenanthramides, avenacosides, and dietary fibre β-glucan. Avenanthramides–polyphenols, to oats, anti-inflammatory antioxidant effects, whilst avenacosides are saponins with anti-bacterial anti-fungal properties. β-Glucans assist in lowering blood cholesterol lead the prevention of diabetes cardiovascular diseases. However, oats undergo many stages processing ensure a sensory...