A5029015570- Cancer-related molecular mechanisms research
- Glioma Diagnosis and Treatment
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Pituitary Gland Disorders and Treatments
- Caveolin-1 and cellular processes
- Obstructive Sleep Apnea Research
- Circadian rhythm and melatonin
- Neuroblastoma Research and Treatments
- Single-cell and spatial transcriptomics
- Cancer Cells and Metastasis
- Extracellular vesicles in disease
- Immune cells in cancer
- Microtubule and mitosis dynamics
- Intensive Care Unit Cognitive Disorders
- Traditional Chinese Medicine Analysis
- Phagocytosis and Immune Regulation
- Cancer Treatment and Pharmacology
- Music Therapy and Health
- Immune Cell Function and Interaction
Shandong Provincial Hospital
2016-2025
Shandong First Medical University
2022-2025
Shandong University
2016-2022
Abstract Ferroptosis is a form of cell death characterized by lipid peroxidation. Previous studies have reported that knockout NF-κB activating protein (NKAP), an RNA-binding protein, increased peroxidation level in naive T cells and induced colon cancer cells. However, there was no literature the relationship between NKAP ferroptosis glioblastoma Notably, mechanism modulating still unknown. Here, we found knockdown Silencing sensitivity to inducers both vitro vivo. Exogenous overexpression...
Glioma is the most common primary brain tumor, with a high rate of recurrence and treatment resistance. Glioblastoma highly invasive, infiltrating surrounding parenchyma, known to cause intracranial metastasis resulting in dismal prognosis. Hypoxia contributes significantly chemo- radiotherapy resistance cancer. Ferroptosis nonapoptotic oxidative cell death that has been identified as potential anticancer mechanism. Sulfasalazine (SAS) activates ferroptosis plays role tumor treatment....
Cancer cells maintain energy metabolism mainly by glycolysis, even under sufficient oxygen conditions. It gives cancer better growth advantages complicated internal environment. KPNA2 is a novel oncogene that has received much attention in recent years, but the exact mechanisms of tumorigenesis and progression are largely unknown. Especially its potential roles metabolic transformation tumors still remain to be explored. The expressions glioblastoma normal human brain samples were analyzed...
Glioblastoma stem-like cells (GSCs) play essential roles in glioma growth, radio-and chemo-resistance, and recurrence.Elimination of GSCs has therefore become a key strategy challenge glioblastoma therapy.Here, we show that melatonin, an indolamine derived from I-tryptophan, significantly inhibited viability self-renewal ability accompanied by decrease stem cell markers.We have identified EZH2-NOTCH1 signaling as the signal pathway regulated effects melatonin GSCs.Instead transcriptionally...
Cancer cells prefer glycolysis for energy metabolism, even when there is sufficient oxygen to make it unnecessary. This called the Warburg effect, and promotes tumorigenesis malignant progression. In this study, we demonstrated that EZH2, a multifaceted oncogenic protein involved in tumor proliferation, invasion metastasis, glioblastoma progression through activation of effect. We observed HIF1α target EZH2 whose necessary EZH2-mediated metabolic adaption, activated upon overexpression....
Glioma is one of the most aggressive malignant brain tumors that characterized with inevitably infiltrative growth and poor prognosis. ARST a novel lncRNA whose expression level significantly decreased in patients glioblastoma multiforme. However, exact mechanisms gliomagenesis are largely unknown.The expressions glioma samples cell lines were analyzed by qRT-PCR. FISH was utilized to detect distribution cells. CCK-8, EdU flow cytometry used examine cellular viability, proliferation...
ABSTRACT This study aimed to check the biological functions and uncover mechanism of armadillo repeat protein C10 (ARMC10) in glioblastoma (GBM). The expression potential mechanisms ARMC10 GBM were analyzed by bioinformatics analysis. In cells, function‐loss experiments used evaluate influences on cell proliferation, invasion, lipid levels, migration colony formation assay, 5‐ethynyl‐2′‐deoxyuridine staining, counting kit‐8 transwell BODIPY wound healing assay. Mouse xenograft models...
Glioma is one of the most aggressive malignant brain tumors which characterized with highly infiltrative growth and poor prognosis. NKAP (NF-κB activating protein) a widely expressed 415-amino acid nuclear protein that overexpressed by gliomas, but its function in glioma was still unknown. CCK8 EDU assay used to examine cell viability vitro, xenograft models nude mice were established explore roles NAKP vivo. The expressions NKAP, Notch1 SDF-1 analyzed immunofluorescence analysis. expression...
It is well established that ncRNAs are emerging as important regulators in various types of cancers, however, their functions and contributions cancers remain insufficiently defined. In this study, we reported the expression levels a long noncoding RNA (lncRNA), named HSP90AA1-IT1 (HSP90AA1 intronic transcript 1), appeared to correlate with pathological grades gliomas high level indicated poor prognosis. Downregulation glioma cell lines significantly suppressed viability, proliferation, EMT,...
Abstract Background and Aims With advancements in imaging microelectrode recording techniques, general anesthesia (GA) has emerged as an alternative option for Parkinson's disease (PD) patients undergoing subthalamic nucleus deep brain stimulation (STN‐DBS). In this study, we compared the advantages disadvantages of using GA local STN‐DBS enhanced recovery after surgery (ERAS). Methods Surgical outcomes were evaluated unified PD rating scales (UPDRS). CT magnetic resonance scans are used to...
Neuroblastoma is the most common extracranial solid tumor in children.The purpose of present study to detect prognostic role and potential therapeutic efficacy T lymphoma invasion metastasis 1 (Tiam1) neuroblastoma.The overexpression Tiam1 protein frequently observed neuroblastoma.Tiam1 expression closely associated with adverse prognosis neuroblastoma risk group classification.Knockdown TIAM1 by lentivirus expressing short hairpin RNA against (sh-TIAM1) inhibited proliferation, cell-cycle...
Abstract Background: Glioma is one of the most aggressive malignant brain tumors that characterized with highly infiltrative growth and poor prognosis. ARST a novel lncRNA which expression significantly decreased in patients glioblastoma multiforme. However, exact mechanisms gliomagenesis are largely unknown. Methods: The expressions glioma samples cell lines were analyzed by qRT-PCR. FISH was utilized to detect distribution cells. CCK-8, EdU flow cytometry used examine cellular viability,...
Abstract Background: Low-grade glioma (LGG) is one of the most common brain tumors in world. Surgical resection often regarded as first choice for treatment. Patients with LGGs have a longer survival time than other types gliomas, but risks recurrence exist which transforms initial to malignant glioblastomas (GBM). For standardized therapy, adjustment treatment options based on early assessment recurrent risk may improve outcome patients. Considering that molecular mechanisms beneath LGGs,...
Abstract Background Glioblastoma is the deadliest type of primary brain tumor with a high rate recurrence and treatment resistance. Hypoxia contributed much to radiotherapy resistance chemoresistance cancer. Ferroptosis nonapoptotic, oxidative cell death identified as potential anticancer mechanism in recent years. Erastin acts ferroptosis activator shows role but relationship between hypoxia erastin glioblastoma has not been explained. This study aimed investigate underlying erastin-induced...