A5066403906- Environmental Chemistry and Analysis
- Environmental Toxicology and Ecotoxicology
- Pesticide and Herbicide Environmental Studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Toxic Organic Pollutants Impact
- Land Use and Ecosystem Services
- Platelet Disorders and Treatments
- Environmental Conservation and Management
- Economic and Environmental Valuation
- Surfactants and Colloidal Systems
- Adaptive optics and wavefront sensing
- CCD and CMOS Imaging Sensors
- Urban Green Space and Health
- Chemistry and Chemical Engineering
- Stellar, planetary, and galactic studies
- Analytical chemistry methods development
- Venomous Animal Envenomation and Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Computational Drug Discovery Methods
- Pesticide Exposure and Toxicity
- Marine Biology and Environmental Chemistry
- Biochemical and Structural Characterization
- Environmental and Social Impact Assessments
- Cell Adhesion Molecules Research
- Ecology and Vegetation Dynamics Studies
SLAC National Accelerator Laboratory
2018-2024
Kavli Institute for Particle Astrophysics and Cosmology
2018-2024
Stanford University
2023-2024
Australian Dental Association
2021
Unilever (United Kingdom)
2005-2020
University of Bedfordshire
2005-2015
University of Oxford
2002-2004
University of Birmingham
2003
Pfizer (United States)
2003
Pfizer (United Kingdom)
2003
Abstract The United Nations’ Sustainable Development Goals have been established to end poverty, protect the planet, and ensure prosperity for all. Delivery of will require a healthy productive environment. An understanding impacts chemicals which can negatively impact environmental health is therefore essential delivery Goals. However, current research on regulation in environment tend take simplistic view do not account complexity real world, inhibits way we manage chemicals. There an...
The Planetary Boundaries (PB) framework represents a significant advance in specifying the ecological constraints on human development. However, to enable decision-makers business and public policy respect these strategic planning, PB needs be developed generate practical tools. With this objective mind, we analyse recent literature highlight three major scientific technical challenges operationalizing approach decision-making: first, identification of thresholds or boundaries with...
A species sensitivity distribution (SSD) is a probability model of the variation sensitivities to stressor, in particular chemical exposure. The SSD approach has been used as decision support tool environmental protection and management since 1980s, ecotoxicological, statistical, regulatory basis applications continue evolve. This article summarizes findings 2014 workshop held by European Centre for Toxicology Ecotoxicology Chemicals UK Environment Agency Amsterdam, Netherlands, on...
Summary The major activation-inducing collagen receptor glycoprotein VI (GPVI) has been cloned within the last two years. It is a member of Ig superfamily proteins and constitutively associated with ITAM-bearing Fc γ-chain (FcR γ-chain). GPVI signals through pathway that involves several used by Fc, B- T-lymphocyte receptors which takes place in glycolipid-enriched membrane domains plasma known as GEMs. Responses to are regulated PECAM-1 (CD31) possibly other ITIM-bearing receptors. Despite...
Abstract Assessment of aquatic effects requires the derivation a predicted no-effect concentration (PNEC). In framework Dutch “Plan Action Laundry and Cleaning Products,” PNECs were derived for linear alkyl benzene sulfonate (LAS), alcohol ethoxylates (AE), ethoxylated sulfates (AES), soap. All stages in an assessment used: initial (assessment factors based mainly on short-term toxicity data), refined (statistical extrapolation long-term comprehensive (field studies). Where necessary (i.e.,...
The ecosystem services (ES) approach is gaining broad interest in regulatory and policy arenas for use landscape management ecological risk assessment. It has the potential to bring greater relevance setting of environmental protection goals assessment posed by chemicals. A workshop, organised under auspices Society Environmental Toxicology Chemistry Europe, brought together scientific experts from European authorities, chemical industry academia discuss evaluate challenges associated with...
ABSTRACT The ecosystem services (ES) concept holds much promise for environmental decision making. Even so, the has yet to gain full traction in decisions and policies of agencies United States, Europe, elsewhere. In this paper we examine opportunities implications including ES risk assessments management that they inform. We assert use will: 1) lead more comprehensive protection; 2) help articulate benefits decisions, policies, actions; 3) better inform derivation quality standards; 4)...
Ecological risk assessment increasingly focuses on risks from chemical mixtures and multiple stressors because ecosystems are commonly exposed to a plethora of contaminants nonchemical stressors. To simplify the task assessing potential mixture effects, we explored 3 land use-related emission scenarios. We applied tiered methodology judge implications emissions chemicals agricultural practices, domestic discharges, urban runoff in quantitative model. The results showed use-dependent...
The ecosystem services approach has gained broad interest in regulatory and policy circles for use ecological risk assessment. Whilst identifying several challenges, scientific experts from European authorities, the chemical industry academia considered applicable to all sectors potentially contributing greater relevance setting assessing environmental protection goals compared current frameworks chemicals. These challenges were addressed workshops develop a common understanding across...
Abstract The present study investigated the route and degree of uptake 2 ionizable pharmaceuticals (diclofenac fluoxetine) 1 compound used in personal care products (triclosan) into sediment‐dwelling worm Lumbriculus variegatus . Studies were done on complete worms (“feeding”) where head was absent (“nonfeeding”) using 14 C‐labeled ingredients. Biota sediment accumulation factors (BSAF), based C, for feeding increased order fluoxetine (0.3) < diclofenac (0.5) triclosan (9), which is...
Identifying ecosystem services that are important to society can help decision-makers prioritize specific for protection. However, may be valued differently by different sections of society. This study sets out an approach assessing the use and prioritization freshwater people in rural urban areas China. Face-to-face interviews were conducted with 30 respondents same region Shandong province. Respondents asked about how they used their local river provided river. In addition, state whether...
Clearly defined protection goals specifying what to protect, where and when, are required for designing scientifically sound risk assessments effective management of chemicals. Environmental specified in EU legislation general terms, resulting uncertainty how achieve them. In 2010, the European Food Safety Authority (EFSA) published a framework identify more specific based on ecosystem services potentially affected by plant products. But applicable is this chemicals with different emission...
It has been proposed that the receptor for von Willebrand factor (vWF), glycoprotein (GP)Ib-IX-V, signals through same pathway as collagen receptor, GPVI, namely via Src kinases, Fc (FcR) γ-chain and Syk, leading to tyrosine phosphorylation of phospholipase Cγ2 (PLCγ2). The aim present study was assess functional significance this in platelet activation by GPIb-IX-V. In washed platelets, vWF/ristocetin vWF/botrocetin stimulate weak FcR γ-chain, Syk PLCγ2, but not adaptor LAT (linker...
An ecosystem services (ES) approach to chemical risk assessment has many potential advantages, but there are also substantial challenges regarding its implementation. We report the findings of a multi-stakeholder workshop that evaluated feasibility adopting an ES using currently available tools and data. Also is added value such would bring environmental decision making. The aim was build consensus across disparate stakeholders co-produce common understanding regulatory benefits implementing...
Ecosystem services-based approach to environmental risk assessment • Logic chains link chemical effects service providing units and ecosystem services.• Ecological models addressed the spatiotemporal magnitude of direct effects.• can add development ecological production functions.• Coherent uniform scenarios need be developed for this.
We previously reported that bradykinin (BK; 1-1000 nM) facilitates norepinephrine (NE) release from cardiac sympathetic nerves. Because BK production increases in myocardial ischemia, endogenous could foster NE and associated arrhythmias. tested this hypothesis guinea pig human ischemia models. administration (100 markedly enhanced exocytotic carrier-mediated overflow hearts subjected to 10- 20-min ischemia/reperfusion, respectively. Ventricular fibrillation invariably occurred after global...