A5041722963- Environmental Toxicology and Ecotoxicology
- Environmental Chemistry and Analysis
- Pharmaceutical and Antibiotic Environmental Impacts
- Pesticide and Herbicide Environmental Studies
- Toxic Organic Pollutants Impact
- Animal testing and alternatives
- Pesticide Residue Analysis and Safety
- Aquatic Invertebrate Ecology and Behavior
- Fish Ecology and Management Studies
- Effects and risks of endocrine disrupting chemicals
- Microplastics and Plastic Pollution
- Analytical chemistry methods development
- Water Quality and Pollution Assessment
- Marine Biology and Environmental Chemistry
- Chemistry and Chemical Engineering
- Water Treatment and Disinfection
- Water Quality Monitoring and Analysis
- Marine Toxins and Detection Methods
- Freshwater macroinvertebrate diversity and ecology
- Pesticide Exposure and Toxicity
- Marine Bivalve and Aquaculture Studies
- Computational Drug Discovery Methods
- Methane Hydrates and Related Phenomena
- Diatoms and Algae Research
- Odor and Emission Control Technologies
Procter & Gamble (United States)
2015-2024
Environmental Protection Agency
2008
Procter & Gamble (Belgium)
2006
Bowling Green State University
1982-1999
Southwestern University
1999
Virginia Tech
1986-1989
The OECD validation study of the zebrafish embryo acute toxicity test (ZFET) for aquatic testing evaluated ZFET reproducibility by 20 chemicals at 5 different concentrations in 3 independent runs least laboratories. Stock solutions and were analytically confirmed 11 chemicals. Newly fertilised eggs (20/concentration control) exposed 96 h to Four apical endpoints recorded daily as indicators lethality: coagulation embryo, lack somite formation, non-detachment tail bud from yolk sac heartbeat....
Abstract Risk assessments for compounds released to the environment typically rely on single-species toxicity studies predict concentrations at which effects may be observed. These are usually conducted with a few species, cultured under optimum conditions (diet, temperature, light, etc.) and tested in clean water constant exposure compound of interest. Chronic data then extrapolated ecosystem during risk that will not adversely impact environment. Several approaches have been developed...
The fish embryo test (FET) is a potential animal alternative for the acute toxicity (AFT) test. A comprehensive validation program assessed 20 different chemicals to understand intra- and interlaboratory variability FET. FET had sufficient reproducibility across range of potencies modes action. In present study, suitability as an model reviewed by relating AFT. total, 985 studies 1531 AFT were summarized. authors performed FET-AFT regressions relationships based on physical-chemical...
This paper brings together over 250 published and unpublished studies on the environmental properties, fate, toxicity of four major, high-volume surfactant classes relevant feedstocks. The surfactants feedstocks covered include alcohol sulfate or (AS), ethoxysulfate (AES), linear alkylbenzene sulfonate (LAS), ethoxylate (AE), long-chain (LCOH). These chemicals are used in a wide range personal care cleaning products. To date, this is most comprehensive report these substance's chemical...
Abstract Investigations into the environmental fate and effects of microplastics have been gaining momentum. Small, insoluble polymeric particles are implicated by scientists in a wide variety studies that used to suggest potential for widespread impacts freshwater marine pelagic sediment environments. An exponential growth scientific publications an increase regulatory attention occurred. However, despite these efforts, hazard is still unknown. To evaluate within risk assessment context, we...
A species sensitivity distribution (SSD) is a probability model of the variation sensitivities to stressor, in particular chemical exposure. The SSD approach has been used as decision support tool environmental protection and management since 1980s, ecotoxicological, statistical, regulatory basis applications continue evolve. This article summarizes findings 2014 workshop held by European Centre for Toxicology Ecotoxicology Chemicals UK Environment Agency Amsterdam, Netherlands, on...
Abstract Flexible, rapid, and predictive approaches that do not require the use of large numbers vertebrate test animals are needed because chemical universe remains largely untested for potential hazards. Development robust new approach methodologies nontesting requires existing information via curated, integrated data sets. The ecological threshold toxicological concern (ecoTTC) represents one such methodology can predict a conservative de minimis toxicity value chemicals with little or no...
Predicting fish acute toxicity of chemicals in vitro is an attractive alternative method to the conventional approach using juvenile and adult fish. The rainbow trout (Oncorhynchus mykiss) cell line assay with RTgill-W1 cells has been designed for this purpose. It quantifies viability fluorescent measurements metabolic activity, cell- lysosomal-membrane integrity on same set cells. Results from over 70 organic attest high predictive capacity test. We here report repeatability...
Environmental risk assessments often use multiple single species toxicity test results and sensitivity distributions (SSDs) to derive a predicted no-effect concentration in the environment, typically 5th percentile of SSD, termed HC5. The shape location distribution are best known when populated with numerous values. To help overcome cost tests, we explored potential U.S. EPA's Interspecies Correlation Estimation (ICE) program predict values from value. ICE uses initial estimate for one...
Species sensitivity distributions (SSD) require a large number of measured toxicity values to define hazard level protective multiple species. This investigation comprehensively evaluated the accuracy SSDs generated from predicted interspecies correlation estimation (ICE) models. ICE models are log–log correlations chemical for pair species that allow be single acute value surrogate were using four (fathead minnow, Pimephales promelas; rainbow trout, Oncorhynchus mykiss; sheepshead...
The fish early-life stage (FELS) test (Organisation for Economic Co-operation and Development [OECD] guideline 210) is the primary used internationally to estimate chronic toxicity in support of ecological risk assessments chemical management programs. As part an ongoing effort develop efficient cost-effective alternatives FELS test, there a need identify describe potential adverse outcome pathways (AOPs) relevant toxicity. To this endeavor, authors outline illustrate overall strategy...
The fish early life-stage (FELS) test guideline (OECD 210 or OCSPP 850.1400) is the most frequently used bioassay for predicting chronic toxicity and supporting aquatic ecological risk assessments around world. For each chemical, FELS requires a minimum of 360 1 to 3 months from initiation termination. Although valuable full life-cycle toxicity, tests are labor resource intensive and, due an emphasis on apical endpoints, provide little no information about chemical mode action. Therefore,...
The mode of toxic action (MOA) is recognized as a key determinant chemical toxicity and an alternative to class-based predictive modeling. However, MOA classification has never been standardized in ecotoxicology, comprehensive comparison tools approaches reported. Here we critically evaluate three methodologies using aquatic data set 3448 chemicals, compare the approaches, assess utility limitations screening early tier assessments. comparisons focused on commonly used tools: Verhaar...
Our ability to conduct whole-organism toxicity tests understand chemical safety has been outpaced by the synthesis of new chemicals for a wide variety commercial applications. As result, scientists and risk assessors are turning mechanistically based studies increase efficiencies in assessment making greater use vitro silico methods evaluate potential environmental human health hazards. In this context, adverse outcome pathway (AOP) framework gained traction regulatory science because it...
Abstract Assessment of aquatic effects requires the derivation a predicted no-effect concentration (PNEC). In framework Dutch “Plan Action Laundry and Cleaning Products,” PNECs were derived for linear alkyl benzene sulfonate (LAS), alcohol ethoxylates (AE), ethoxylated sulfates (AES), soap. All stages in an assessment used: initial (assessment factors based mainly on short-term toxicity data), refined (statistical extrapolation long-term comprehensive (field studies). Where necessary (i.e.,...
Animal alternative tests are gaining serious consideration in an array of environmental sciences, particularly as they relate to sound management chemicals and wastewater discharges. The ILSI Health Environmental Sciences Institute the European Centre for Ecotoxicology Toxicology Chemicals (ECETOC) held International Workshop on Application Fish Embryo Test March, 2008. This relatively young discipline is following advances animal alternatives human safety it advisable develop a broad...
Hypothesis-based no-effect-concentration (NOEC) and regression-based x% effect concentration (ECx) values are common statistical approaches used to summarize ecotoxicological effects. Controversy over the NOEC model has prompted a movement toward discontinuation of in favor ECx, but best surrogate for not yet been determined. Historically, 10% 20% concentrations (EC10 EC20) have treated as analogs. Given these measurements' importance ecotoxicology, further understanding relationships...