Graham Whale

ORCID: 0000-0002-2371-4386
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About
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Research Areas
  • Environmental Toxicology and Ecotoxicology
  • Toxic Organic Pollutants Impact
  • Pharmaceutical and Antibiotic Environmental Impacts
  • Environmental Chemistry and Analysis
  • Animal testing and alternatives
  • Effects and risks of endocrine disrupting chemicals
  • Water Quality Monitoring and Analysis
  • Microbial bioremediation and biosurfactants
  • Analytical chemistry methods development
  • Pesticide and Herbicide Environmental Studies
  • Corrosion Behavior and Inhibition
  • Gene expression and cancer classification
  • Mass Spectrometry Techniques and Applications
  • Marine and Offshore Engineering Studies
  • Chemistry and Chemical Engineering
  • Water Quality and Pollution Assessment
  • Petroleum Processing and Analysis
  • Marine Biology and Environmental Chemistry
  • Pesticide Residue Analysis and Safety
  • Environmental Conservation and Management
  • Oil Spill Detection and Mitigation
  • Molecular Biology Techniques and Applications
  • Risk and Safety Analysis
  • Natural Resources and Economic Development
  • Genetics, Aging, and Longevity in Model Organisms

Shell (United Kingdom)
2009-2021

Concawe
2021

Shell (Netherlands)
1991-2018

Cheshire West and Chester
2003-2007

Animal alternative tests are gaining serious consideration in an array of environmental sciences, particularly as they relate to sound management chemicals and wastewater discharges. The ILSI Health Environmental Sciences Institute the European Centre for Ecotoxicology Toxicology Chemicals (ECETOC) held International Workshop on Application Fish Embryo Test March, 2008. This relatively young discipline is following advances animal alternatives human safety it advisable develop a broad...

10.1002/ieam.48 article EN Integrated Environmental Assessment and Management 2010-01-22

Abstract When addressing the use of fish for environmental safety chemicals and effluents, there are many opportunities applying principles 3Rs: Reduce, Refine, Replace. The current regulatory testing strategy bioconcentration secondary poisoning has been reviewed, alternative approaches that provide useful information described. Several can be used to reduce number in Organization Economic Cooperation Development (OECD) Test Guideline 305, including vivo test methods such as dietary...

10.1002/ieam.5630030102 article EN Integrated Environmental Assessment and Management 2007-01-01

The ecotoxicity testing of chemicals for prospective environmental safety assessment is an area in which a high number vertebrates are used across variety industry sectors. Refining, reducing, and replacing the use animals such as fish, birds, amphibians this purpose addresses ethical concerns increasing legislative requirements to consider alternative test methods. Members UK-based National Centre Replacement, Refinement Reduction Animals Research (NC3Rs) Ecotoxicology Working Group,...

10.1002/ieam.1703 article EN other-oa Integrated Environmental Assessment and Management 2015-10-06

Water is used in petroleum oil refineries significant volumes for cooling, steam generation and processing of raw materials. Effective water management required at to ensure their efficient responsible operation with respect the environment. However, ascertaining potential environmental risks associated discharge refinery effluents receiving waters challenging because compositional complexity. Recent European research regulatory initiatives propose a more holistic approach including...

10.1016/j.chemosphere.2021.132146 article EN cc-by Chemosphere 2021-09-04

Large-scale toxicogenomic screening approaches offer great promise for generating a bias-free system-wide view of toxicological effects and modes-of-action chemicals ecotoxicants. However, early applications microarray technology have identified relatively small groups responding genes with which to define new targets analysis by conventional means. We trialled more intensive approach the design interpretation array experiments incorporating balanced interwoven ANOVA higher levels biological...

10.1093/toxsci/kfq237 article EN Toxicological Sciences 2010-08-11

Clearly defined protection goals specifying what to protect, where and when, are required for designing scientifically sound risk assessments effective management of chemicals. Environmental specified in EU legislation general terms, resulting uncertainty how achieve them. In 2010, the European Food Safety Authority (EFSA) published a framework identify more specific based on ecosystem services potentially affected by plant products. But applicable is this chemicals with different emission...

10.1016/j.scitotenv.2016.12.083 article EN cc-by-nc-nd The Science of The Total Environment 2016-12-24

Urban regions of the world are expanding rapidly, placing additional stress on water resources. bodies serve many purposes, from washing and sources drinking to transport conduits for storm drainage effluent discharge. These receive chemical emissions arising either single or multiple point sources, diffuse which can be continuous, intermittent, seasonal. Thus, aquatic organisms in these exposed temporally compositionally variable mixtures. We have delineated source-specific signatures...

10.1002/etc.3975 article EN cc-by Environmental Toxicology and Chemistry 2017-09-01

Current biodegradation screening tests are not specifically designed for persistence assessment of chemicals, often show high inter- and intra-test variability, give false negative results. Based on previous studies recommendations, an international ring test involving 13 laboratories validated a new method marine with focus improving the reliability to determine environmental degradation potential chemicals. The incorporated increased bacterial cell concentrations better represent microbial...

10.1021/acs.est.9b07710 article EN Environmental Science & Technology 2020-03-12

Environmental Toxicology and ChemistryVolume 37, Issue 5 p. 1252-1259 ET&C Perspectives How omics technologies can enhance chemical safety regulation: perspectives from academia, government, industry Bruno Campos, Corresponding Author Campos Brunocampus@gmail.com orcid.org/0000-0002-3701-4858 Department of Chemistry, Institute Assessment Water Research (IDAEA, CSIC), Jordi Girona, Barcelona, Spain Address correspondence to Brunocampus@gmail.comSearch for more papers by this authorJohn K....

10.1002/etc.4079 article EN Environmental Toxicology and Chemistry 2018-04-26

Significant progress has been made in the scientific understanding of factors that influence outcome biodegradation tests used to assess persistence (P) chemicals. This needs be evaluated whether recently acquired knowledge could enhance existing regulations and environmental risk assessments. Biodegradation have limitations, which are accentuated for "difficult-to-test" substances, failure recognize these can potentially lead inappropriate conclusions regarding a chemical's persistence....

10.1002/ieam.4438 article EN Integrated Environmental Assessment and Management 2021-04-29
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