A5064939169- Protein Degradation and Inhibitors
- Retinoids in leukemia and cellular processes
- Acute Myeloid Leukemia Research
- interferon and immune responses
- CAR-T cell therapy research
- Acute Lymphoblastic Leukemia research
- Immunotherapy and Immune Responses
- Silicon Effects in Agriculture
- Aluminum toxicity and tolerance in plants and animals
- Hematopoietic Stem Cell Transplantation
- Clay minerals and soil interactions
- Immune Cell Function and Interaction
- Radiomics and Machine Learning in Medical Imaging
- Glycosylation and Glycoproteins Research
- Cardiac Fibrosis and Remodeling
- Immune cells in cancer
- Climate variability and models
- Breast Cancer Treatment Studies
- Chemokine receptors and signaling
- Biochemical and Molecular Research
- Tree-ring climate responses
- Advanced biosensing and bioanalysis techniques
- Cancer Immunotherapy and Biomarkers
- Signaling Pathways in Disease
- Lung Cancer Treatments and Mutations
University of Giessen
2025
Karlsruhe Institute of Technology
2023-2024
Ludwig-Maximilians-Universität München
2018-2024
Institute of Bioinformatics and Systems Biology
2024
Inserm
2023
Maison des Sciences de l’Homme de Dijon
2023
Université de Bourgogne
2023
University Hospital Ulm
2022
Universität Ulm
1993-2021
Universidade Federal de São Carlos
2021
Abstract Arterial macrophages have different developmental origins, but the association of macrophage ontogeny with their phenotypes and functions in adulthood is still unclear. Here, we combine fate-mapping analysis single-cell RNA sequencing to establish cellular identity during homeostasis, response angiotensin-II (AngII)-induced arterial inflammation. Yolk sac erythro-myeloid progenitors (EMP) contribute substantially adventitial give rise a defined cluster resident immune cells...
Abstract. Afforestation affects the earth's climate system by changing biogeochemical and biogeophysical characteristics of land surface. While regional effects afforestation are well understood in tropics high latitudes, its impact on midlatitudes is still subject scientific discussions. The general conditions Europe during last decades investigated this study. For purpose, simulations performed with different forest cover fractions over Europe. In a first simulation, considered, while not...
Skeletal muscle plays a pivotal role in physical activity, protein storage and energy utilization. wasting due to immobilization, aging, muscular dystrophy cancer cachexia has negative impacts on the quality of life. The deletion myostatin, growth differentiation factor-8 (GDF-8) augments mass through hyperplasia hypertrophy fibers. present study examines impact myostatin using CRISPR/Cas9 editing myogenic (MD) C2C12 stem cells. A total five loci were targeted guided RNAs that had been...
In acute myeloid leukemia (AML) without retinoic acid receptor (RAR) rearrangement, the effect of all-trans-retinoic (ATRA) is still poorly understood despite an association NPM1 mutation and ATRA response. Recently, preferentially expressed antigen in melanoma (PRAME) has been shown to be a dominant repressor RAR signaling.Thus, we further investigated response mechanisms, especially impact PRAME expression on responsiveness. We profiled gene diagnostic samples derived from our AML HD98B...
The aim of this study was to compare the effects feeding homozygous β-CN A1 or A2 milk on body composition, intake, and growth German Holstein (GH), Simmental (GS), crossbred (CR) dairy calves both sexes during first 2 wk life. A total 104 (n = 54 female, f; n 50 male, m) from breed groups GH 23), GS 61), × 20) were evaluated. Calves weighed after birth received colostrum ad libitum. On second day, alternately housed in pairs double-igloo systems according their random order either 52; 27...
Leukemic stem cells (LSC) might be the source for leukemic disease self‐renewal and account relapse after treatment, which makes them a critical target further therapeutic options. We investigated role of cytotoxic T‐lymphocytes (CTL) counteracting recognizing LSC. Leukemia‐associated antigens (LAA) represent immunogenic structures to enriched LSC‐containing fraction 20 AML patients hematopoietic (HSC) healthy volunteers. Using microarray analysis qRT‐PCR we detected high expression several...
Summary Nucleophosmin1 (NPM1) is one of the most commonly mutated genes in AML and often associated with a favourable prognosis. Immune responses play an increasing role treatment decisions; however, immune checkpoint inhibition still not clear. To address this, we investigated specific against NPM1, three other leukaemia‐associated antigens (LAA), PRAME, Wilms' tumour 1 RHAMM patients. We T cell leukaemic progenitor/stem cells (LPC/LSC) using colony‐forming immunoassays flow cytometry....
Background: diagnosis of pediatric autoimmune gastritis (AIG) in children is important due to poor outcome and risk malignancy. This condition often underestimated the clinico-pathologic diagnostic work-up, leading delayed time-to-diagnosis. To increase awareness this population, we present two cases encountered at our institution, discuss their clinical, biological histological presentations relation with evidence from literature, propose an algorithm for follow-up AIG children. Case...
Gallium scanning in malignant fibrous histiocytomaPF Zazzaro, JE Bosworth, V Schneider and JJ ZelenakAudio Available | Share
Myoepithelioma is a rare and usually benign salivary gland tumor derived from myoepithelial cells. Variability in cellular morphology stromal composition leads to diagnostic pitfalls on fine‐needle aspiration cytology; therefore, histology immunohistochemistry are often required for definitive diagnosis. We describe case of parotid myoepithelioma 76‐year‐old woman, which was discovered incidentally cerebral magnetic resonance imaging. Fine‐needle sampled cohesive aggregates spindle‐shaped...
3592 Background: Combining targeted agents with different mechanisms of action is an attractive approach to developing improved treatments for cancer. Cediranib (AZD2171) oral, highly potent and selective inhibitor vascular endothelial growth factor (VEGF) signaling, activity against VEGFR-1, -2, -3. AZD0530 a potent, oral Src additional Bcr-Abl. The primary objective this ongoing study evaluate the safety tolerability treatment cediranib in combination define doses further investigation....
Although the detection of HTLV antibodies became mandatory in Argentinean blood banks since 2005, there is no recommendation on how to perform screening. As a consequence, variable number false positives depending kit used. The aim present study was evaluate performance six commercial screening tests available currently for initial diagnosis HTLV-1/2 infection South America. positive panel included 14 HTLV-1 and 13 HTLV-2 samples confirmed by WB (HTLV-1/2 MP Diagnostics). negative 233...
Abstract Obesity due to high calorie intake induces cardiac hypertrophy and dysfunction, thus contributing cardiovascular morbidity mortality. Recent studies in aging suggest that oral supplementation with the natural polyamine spermidine has a cardioprotective effect. Here, hypothesis was tested or voluntary activity alone combination protect heart from adverse effects induced by obesity. Therefore, C57Bl/6 mice ( n = 8–10 per group) were subjected control fat diet (HFD) left untreated,...
Aurora kinases are serine/threonine which play an important role in the process of mitosis and cell cycle regulation. kinase inhibitors described to sensitize malignant cells cytosine arabinoside specific antibodies by mediating apoptosis. overexpressed most acute leukemias but also solid tumors. In this study we investigated whether epitopes derived from A B able elicit cellular immune responses patients with myeloid leukemia (AML) investigate their as potential targets for immunotherapy....