A5018410148- Asthma and respiratory diseases
- Mast cells and histamine
- Angiogenesis and VEGF in Cancer
- Neuroendocrine regulation and behavior
- Cancer Genomics and Diagnostics
- CAR-T cell therapy research
- Workplace Violence and Bullying
- Glaucoma and retinal disorders
- Cancer, Hypoxia, and Metabolism
- Food Allergy and Anaphylaxis Research
- Retinal Diseases and Treatments
- Allergic Rhinitis and Sensitization
- Colorectal Cancer Treatments and Studies
- Healthcare Decision-Making and Restraints
- Ethics in medical practice
- Neuroscience and Neuropharmacology Research
- Chemical Synthesis and Analysis
- Cell Adhesion Molecules Research
- Colorectal Cancer Screening and Detection
Newman University
2024
Southmead Hospital
2008
University of Bristol
2005-2008
Loughborough University
1985-2005
AstraZeneca (United Kingdom)
2005
As described in the preceding companion paper, bronchoalveolar lavage (BAL) of primate Macaca arctoides infected with nematode Ascaris suum yields a population cells containing high proportion mast (21%). Nedocromil sodium, new drug undergoing clinical evaluation for treatment reversible obstructive airways disease, inhibited release histamine, LTC4, and PGD2 from these challenged antigen (with IC30 values 2.1 X 10(-6) M, 2.3 1.9 respectively) anti-human IgE (IC30 4.7 1.3 respectively)....
Large numbers of functional mast cells were obtained by bronchoalveolar lavage (BAL) Macaca arctoides monkeys that had been infected with the nematode Ascaris suum. These cells, which 21% released histamine, LTC4, and PGD2 in a concentration-dependent fashion when challenged ascaris antigen or antibody to human IgE. However, there was no release histamine these compound 48/80. The amount mediator highly dependent on sensitivity immunologic challenge, but generally range 2 5 micrograms (30...
Introduction: Moral suffering (MS) is psycho-emotional harm derived from a conflict between one’s circumstances and deeply held moral values. It includes the constructs of distress (MD) injury (MI) characterized by constraints or mandates preventing perceived morally correct event. Evidence has demonstrated application MS in helping professions, research linked to deterioration mental health, self-identity, worldview, job-performance. Aims: In this study, we examined relationship MD, MI,...
Cells were obtained from the lungs of Macaque monkeys by bronchoalveolar lavage in order to study role cellular interactions release leukotriene C 4 (LTC ). In normal monkeys, macrophages most abundant cell type recovered, whereas sensitized with Ascaris suum there was an increase numbers eosinophils and mast cells recovered. Challenge both groups animals optimal concentration opsonized zymosan (OPZ) resulted time‐dependent LTC macrophages. However, significantly greater donors compared...
SUMMARY It is possible to induce eosinophilia in congenitally athymic rats by infection with the parasite Ascaris suum . Athymic bronchial associated increased expression of IL‐5 and eotaxin mRNA, presence residual T cells mast cells. Anamnestic mastocytosis particularly pronounced this study we examine relationship between cell degranulation IgE production following infection. Incubation peritoneal from anti‐IgE induced dose‐dependent degranulation, as measured histamine release. However,...
The substituted chromone carboxylic acid FPL 52694 inhibited models of IgE-mediated immediate hypersensitivity reactions in the rat by a mechanism similar to that sodium cromoglycate. compound was more potent than cromoglycate but unlike active following oral administration.
1Microvascular Research Laboratories University of Bristol 2Department Plastic Surgery Frenchay Hospital, Bristol, UK Abstracts the Perspectives in Melanoma X and The Third Annual International Congress, 14–16 September 2006, Noordwijk, Netherlands