A5056443288- Plant and animal studies
- Plant Parasitism and Resistance
- Transgenic Plants and Applications
- Cancer Research and Treatments
- Biochemical and Structural Characterization
- Urological Disorders and Treatments
- Fossil Insects in Amber
- Antimicrobial Peptides and Activities
- Plant Reproductive Biology
- Cancer Genomics and Diagnostics
- Viral Infectious Diseases and Gene Expression in Insects
- Plant Virus Research Studies
- Immunotherapy and Immune Responses
- Urologic and reproductive health conditions
- Plant Molecular Biology Research
- Neuropeptides and Animal Physiology
- Ecology and Vegetation Dynamics Studies
- Health and Wellbeing Research
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Viral Infections and Immunology Research
- Virus-based gene therapy research
- Congenital Heart Disease Studies
- CRISPR and Genetic Engineering
- Nursing education and management
First Affiliated Hospital of Zhengzhou University
2024
Beijing Children’s Hospital
2023-2024
Capital Medical University
2023-2024
Anhui Provincial Children's Hospital
2024
Soochow University
2024
First Affiliated Hospital of Soochow University
2024
China West Normal University
2024
Baoding People's Hospital
2023
Nanjing University of Chinese Medicine
2023
Xuzhou Medical College
2021
Objectives To investigate how core competency and self-efficacy of newly graduated nurses affect their experience transition shock, to determine the relationship between these factors. Design A cross-sectional study. Methods 262 participated in a study by using demographic data, shock scale, inventory for registered scale scale. Results Among nurses, score was 77.641±24.140, 125 (109.5, 163.5) 2.5 (2,3), all which were at moderate level. The had negative impact on (β=−0.151, p=0.026;...
Summary To minimize interspecific pollination, it has been suggested that pollen is placed on different parts of a pollinator's body corresponding to the conspecific location pickup by stigma. Although P edicularis regarded as classic example pollinator‐mediated floral isolation, such reciprocal placement not demonstrated experimentally. This leads us question previous observations release in species. Here, we show grains are released from tip, rather than basal opening, galea (the hoodlike...
Gambogic acid (GA) is a natural compound derived from Chinese herbs that has been approved by the Food and Drug Administration for clinical trials in cancer patients; however, its molecular targets have not thoroughly studied. Here, we report GA inhibits tumor proteasome activity, with potency comparable to bortezomib but much less toxicity. First, acts as prodrug only gains proteasome-inhibitory function after being metabolized intracellular CYP2E1. Second, GA-induced inhibition...
Interest in pollinator-mediated evolutionary divergence of flower phenotype and speciation plants has been at the core plant studies since Darwin. Specialized pollination is predicted to lead reproductive isolation promote among sympatric species by promoting partitioning (1) pollinators used, (2) when are or (3) sites pollen placement. Here this last mechanism investigated observing accuracy Pedicularis (Orobanchacae). Pollinator behaviour was observed on three (P. densispica, P. tricolor...
Abstract Aging is an intricate process involving interactions among multiple factors, which one of the main risks for chronic diseases, including Alzheimer's disease (AD). As a member cysteine protease, cathepsin S (CTSS) has been implicated in inflammation across various diseases. Here, we investigated role neuronal CTSS aging and AD started by examining expression hippocampus neurons mice identified significant increase, was negatively correlated with recognition abilities. Concurrently,...
Fungi that infect plants, animals or humans pose a serious threat to human health and food security. Antifungal proteins (AFPs) secreted by filamentous fungi are promising biomolecules could be used develop new antifungal therapies in medicine agriculture. They small highly stable with specific potent activity against fungal pathogens. However, their exploitation requires efficient, sustainable safe production systems. Here, we report the development of an easy-to-use, open access viral...
Antimicrobial peptides (AMPs) have potent and durable antimicrobial activity to a wide range of fungi bacteria. The growing problem drug-resistant pathogenic microorganisms, together with the lack new effective compounds, has stimulated interest in developing AMPs as anti-infective molecules. PAF102 is an AMP that was rationally designed for improved antifungal properties. This cell penetrating peptide specific against major fungal pathogens. Cecropin A natural strong fast lytic bacterial...
Hibiscus mutabilis (cotton rose) is a deciduous shrub or small tree of the Malvaceae family. Here, we report chromosome-scale assembly H. genome based on combination single-molecule sequencing and Hi-C technology. We obtained an optimized 2.68 Gb with scaffold N50 length 54.7 Mb. An integrated strategy homology-based, de novo, transcriptome-based gene predictions identified 118,222 protein-coding genes. Repetitive DNA sequences made up 58.55% genome, LTR retrotransposons were most common...
Hepatocellular carcinoma (HCC) is a fatal malignant tumor, but effective clinical interventions are limited. PLGA/PEI-mediated DNA vaccine encoding the dual targets of high-mobility group box 1 (HMGB1) or GPC3 was developed for HCC treatment. Compared with PLGA/PEI-GPC3 immunization, PLGA/PEI-HMGB1/GPC3 co-immunization significantly inhibited subcutaneous tumor growth, while increasing infiltration CD8+T cells and DCs. Furthermore, induced strong CTL effect promoted functional cell...
PurposeClinical development of cancer drugs has a low success rate. Prognostic and predictive biomarkers using minimally invasive approaches hold promise for increasing the probability by enabling disease characterization, patient selection early detection drug treatment effect. Enumeration molecular characterization circulating tumor cells (CTC) may address some these needs, thus were evaluated utility in Phase I solid clinical study. Experimental DesignBlood samples CTC analysis obtained...
In this study, we used combined transcriptomics and metabolomics to analyze the H. mutabilis cultivar’s genetic physiological mechanisms during three flower color transition periods (from white pink, then from pink red) within span of one day. As a result, 186 genes were found be significantly increased with deepening color; these mainly involved in expression peroxidase 30, zinc finger protein, phosphate transporter PHO1, etc. contrast, 298 downregulated color, including those probable...
Members of the superfamily seven transmembrane receptors, known as G protein-coupled receptors (GPCRs), are important targets for many therapeutic areas in drug discovery. A homogeneous guanosine 5'-O-(3-[(35)S]thio)triphosphate ([(35)S]GTPgammaS) scintillation proximity assay (SPA) binding targeting a Galphai-coupled GPCR recombinantly expressed membranes Chinese hamster ovary (CHO) cells was developed and miniaturized into 1,536-well plate format. The primary ultra-high-throughput screen...
Many insect species provide pollination services for flowering plants. However, the efficiency of various pollinator varies greatly due to differences in body size, foraging behavior, and visitation rate. Here, we investigated a generalist plant Hibiscus mutabilis, compared rate, five species. Our observations revealed that moth was relatively lower than all bee The length increased amount transferred pollen, larger bees tended remove more pollen from anthers deposit on stigmas, resulting...
RETINOBLASTOMA-RELATED (RBR) is an essential gene in plants, but its molecular function outside of role cell cycle entry remains poorly understood. We characterized the functions OsRBR1 and OsRBR2 plant growth development rice using both forward- reverse-genetics methods. The two genes were coexpressed performed redundant roles vegetative organs exhibited separate flowers. was highly expressed floral meristem regulated expression homeotic to ensure organ formation. Mutation caused loss...
PAFs are short cationic and tryptophan-rich synthetic peptides with cell penetrating antifungal activity. They show potent selective killing activity against major fungal pathogens, low toxicity to other eukaryotic bacterial cells. These properties make them a promising alternative fulfill the need of novel antifungals potential applications in crop protection, food preservation medical therapies. However, difficulties cost-effective manufacturing by chemical synthesis or biotechnological...
A new genus with two species, Codoserphus calophlebius gen. et sp. nov. and euneurus nov., assigned to the subfamily Mesoserphinae of Mesoserphidae, are described from Jehol Biota, Early Cretaceous Yixian Formation Huangbanjigou Village in Liaoning, China. is characterized by its fore wing all major veins present, not reduced, l cu-a distal 1-M wing. An updated key given for genera Mesoserphidae around world.
Two new fossil species, Archaeohelorus polyneurus sp. n. and A. tensus n., assigned to the genus Shih, Feng & Ren, 2011 of Heloridae (Hymenoptera), are reported from late Middle Jurassic, Jiulongshan Formation Inner Mongolia, China. Based on well-preserved forewings hind wings these specimens, diagnosis is emended: forewing 2cu-a intersecting Cu Rs+M at same point or postfurcal, wing may have tubular veins C, Sc+R, R, Rs, M+Cu, M distinct, simplified venation. The findings also elucidate...
Abstract Human α 2 ‐macroglobulin (α M), pregnancy zone protein (PZP), rat 1 M and acute‐phase belong to the gene family of proteins, which can react covalently with nucleophilic monoamines yield monoamine‐activated (MA) macroglobulins. The MA forms human M, PZP have been demonstrated previously inhibit various neurotrophin‐promoted neuronal activities, whereas MA‐α is neurostimulatory all native macroglobulins are generally inactive. mechanism neuromodulation unknown, but it has postulated...
e20093 Background: Small-cell lung cancer (SCLC) is a very aggressive with high metastatic potential. Many patients SCLC initially respond to standard-of-care therapy but have rapid recurrence. The potential and recurrence may be driven by stem cells (CSCs). MEDI0639 human monoclonal antibody that selectively binds DLL4 inhibits DLL4-Notch receptor signaling. Preclinical studies demonstrated blockade reduces tumor cell proliferation frequency in various tumors. objective of this study was...