A5085294759- Cancer Genomics and Diagnostics
- Renal cell carcinoma treatment
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Chromatin Remodeling and Cancer
- Oral Health Pathology and Treatment
- RNA modifications and cancer
- Psychological Well-being and Life Satisfaction
- Mechanisms of cancer metastasis
- Single-cell and spatial transcriptomics
- Urological Disorders and Treatments
- Speech Recognition and Synthesis
- Renal and related cancers
- SARS-CoV-2 and COVID-19 Research
- Speech and Audio Processing
- Psychological and Temporal Perspectives Research
- interferon and immune responses
- RNA regulation and disease
- Genital Health and Disease
- Cancer Immunotherapy and Biomarkers
- Music Technology and Sound Studies
- Congenital heart defects research
- Music and Audio Processing
- Speech and dialogue systems
- Death Anxiety and Social Exclusion
The University of Texas MD Anderson Cancer Center
2022-2025
Scripps MD Anderson Cancer Center
2024
Aligarh Muslim University
2022-2023
Jawaharlal Nehru Medical College Hospital
2022-2023
Shifa International Hospital
2023
Balochistan University of Information Technology, Engineering and Management Sciences
2023
CMH Lahore Medical College and Institute of Dentistry
2021
Bahria University
2020
Abstract Molecular routes to metastatic dissemination are critical determinants of aggressive cancers. Through in vivo CRISPR–Cas9 genome editing, we generated somatic mosaic genetically engineered models that faithfully recapitulate renal tumors. Disruption 9p21 locus is an evolutionary driver systemic disease through the rapid acquisition complex karyotypes cancer cells. Cross-species analysis revealed recurrent patterns copy number variations, including 21q loss and dysregulation...
Renal medullary carcinoma (RMC) is an aggressive kidney cancer that almost exclusively develops in individuals with sickle cell trait (SCT) and always characterized by loss of the tumor suppressor SMARCB1 . Because renal ischemia induced red blood sickling exacerbates chronic hypoxia vivo, we investigated whether confers a survival advantage under setting SCT. Hypoxic stress, which naturally occurs within medulla, elevated Our findings showed hypoxia-induced degradation protected cells from...
Abstract It is unclear how cells counteract the potentially harmful effects of uncoordinated DNA replication in context oncogenic stress. Here, we identify WRAD (WDR5/RBBP5/ASH2L/DPY30) core as a modulator pancreatic ductal adenocarcinoma (PDAC) models. Molecular analyses demonstrated that interacts with replisome complex, disruption DPY30 resulting re-replication, damage, and chromosomal instability (CIN) without affecting cancer cell proliferation. Consequently, immunocompetent models,...
Abstract Mesenchymal plasticity has been extensively described in advanced and metastatic epithelial cancers; however, its functional role malignant progression, dissemination therapy response is controversial. More importantly, the of mesenchymal transition (EMT) cell tumor heterogeneity, clonal selection evolution poorly understood. Functionally, our work clarifies contribution EMT to progression metastasis pancreatic cancer. We leveraged ad hoc somatic mosaic genome engineering, lineage...
This research investigates the transferability of Automatic Speech Recognition (ASR)-robust Natural Language Understanding (NLU) models from controlled experimental conditions to practical, real-world applications. Focused on smart home automation commands in Urdu, study assesses model performance under diverse noise profiles, linguistic variations, and ASR error scenarios. Leveraging UrduBERT model, employs a systematic methodology involving data collection, cross-validation, transfer...
Abstract Renal medullary carcinoma (RMC) is a rare but highly aggressive SMARCB1-deficient kidney cancer that mainly afflicts young individuals of African descent and has few treatment options. Despite the advancements in immune checkpoint therapy (ICT) for other cancers, its efficacy against RMC remains elusive. The majority patients treated with ICT have experienced aggressively progressive disease as best response. This hyperprogression was confirmed our prospective clinical trial...
Using Mel-spectrograms, this study evaluates the effectiveness of Convolutional Neural Networks (CNN) and Recurrent (RNNs). Mel-spectrograms are justified by their non- linearity similarity to human hearing system. This uses over 200 tracks The Beatles Queen collected through Music Information Retrieval Evaluation Exchange. Data augmentation approaches used increase accuracy on unusual chords. paper presents a 3-layer 2D CNN model trained major minor chords then expanded different types...
The present paper aimed to investigate the effects of relationship status on positive psychological functioning among adults with different marital statuses. sample comprised N = 246Pakistanis, 95 males and 151 females, their age ranging from 20 – 30 years (M=21.17, SD=3.10). objectives current study were chieved through demographic information form Positive Psychological Functioning Scales (PPF), which were administered participants online channels. It was hypothesized that there would be...
SMARCB1 is one of the core subunits SWI/SNF complex, an ATP-dependent chromatin remodeling complex.• Malignancies are characterized by simple genomes and lack somatic events, suggesting that dysregulation machinery sufficient to induce highly malignant states [1].• Although dysregulations related approximately 20% human malignancies [2], conditional genetic models SMARCB1-deficient tumors has made it difficult investigate molecular bases dependencies associated with loss due embryonic...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Naaz S, Khan HQ, Amin SS, Kaushik Qadri S. PRIDE syndrome with lumbosacral hypertrichosis. Dermatology Review/Przegląd Dermatologiczny. 2022;109(4):321-326. doi:10.5114/dr.2022.123989. APA Naaz, S., Khan, H. Q., Amin, Kaushik, & Qadri, (2022). Dermatologiczny, 109(4), 321-326. https://doi.org/10.5114/dr.2022.123989 Chicago Saima, Hania Q Syed S Shriya and Shagufta Qadri. 2022. "PRIDE hypertrichosis"....
employed to minimize their failure.
 METHODOLOGY:
 A cross sectional descriptive was conducted in 150 dentists of Sharif College Dentistry, SMDC, Lahore from June 2019 July 2020 after obtaining ethical approval Medical Research Centre (SMRC). Data collected using a pre-validated questionnaire. analyzed SPSS 23.
 RESULTS:
 There no significant association between years clinical experience and case selection (p=0.436). The reason for composites as posterior restorations...