A5092102934- Glycosylation and Glycoproteins Research
- Pancreatic function and diabetes
- Cancer, Lipids, and Metabolism
- Enzyme Catalysis and Immobilization
- Galectins and Cancer Biology
- Attention Deficit Hyperactivity Disorder
- Diabetes and associated disorders
- Microbial Metabolic Engineering and Bioproduction
- Advanced Biosensing Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
Institute of Chemistry of the Slovak Academy of Sciences
2023-2024
Slovak Academy of Sciences
2023-2024
Indian Institute of Technology Bombay
2018
Background: Aberrant glycosylation is a hallmark of cancer and thereby has an excellent potential for the discovery novel biomarkers. Impairments in glycan composition lipoproteins impact their functional properties can be associated with various diseases, including cancer. This research still its infancy; however, it lead to development new diagnostic disease stratification approaches as well therapeutic strategies. Therefore, we aimed evaluate anomalies O-glycosylation apolipoprotein C-III...
Changes in protein glycosylation are associated with most biological processes, and the importance of glycomic analysis research disorders is constantly increasing, including neurodevelopmental field. We glycoprofiled sera 10 children attention-deficit hyperactivity disorder (ADHD) matching healthy controls for 3 types samples: whole serum, after depletion abundant proteins (albumin IgG), isolated IgG. The analytical methods used were a lectin-based glycoprotein microarray enabling...
Abstract Commercial exploitation of enzymes in biotransformation necessitates a robust method for enzyme production that yields high titer. Nitrilases are family hydrolases can transform nitriles to enantiopure carboxylic acids, which important pharmaceutical intermediates. Here, we report fed-batch uses defined medium and involves growth under carbon limiting conditions using DO-stat feeding approach combined with an optimized post-induction strategy, yielding cell densities maximum levels...
Protein-carbohydrate interactions happen to be a crucial facet of biology, discharging myriad functions. Microarrays have become premier choice discern the selectivity, sensitivity and breadth these in high-throughput manner. The precise recognition target glycan ligands among plethora others is central for any glycan-targeting probe being tested by microarray analyses. Ever since introduction as an elemental tool glycoprofiling, numerous distinct array platforms possessing different...