A5066618151- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Electrochemical sensors and biosensors
- Carbohydrate Chemistry and Synthesis
- Analytical Chemistry and Sensors
- Advanced biosensing and bioanalysis techniques
- Microfluidic and Capillary Electrophoresis Applications
- Advanced Biosensing Techniques and Applications
- Advanced Proteomics Techniques and Applications
- Galectins and Cancer Biology
- Microbial Metabolic Engineering and Bioproduction
- Blood properties and coagulation
- Biosensors and Analytical Detection
- Electrochemical Analysis and Applications
- Mass Spectrometry Techniques and Applications
- Conducting polymers and applications
- Molecular Junctions and Nanostructures
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer, Lipids, and Metabolism
- Influenza Virus Research Studies
- Proteoglycans and glycosaminoglycans research
- Photosynthetic Processes and Mechanisms
- Growth Hormone and Insulin-like Growth Factors
- Infant Nutrition and Health
- Erythrocyte Function and Pathophysiology
Institute of Chemistry of the Slovak Academy of Sciences
2015-2024
Slovak Academy of Sciences
2015-2024
Comenius University Bratislava
2002-2008
Biorealis (Slovakia)
2007
AREA Science Park
1998-1999
Vitenparken
1999
Slovak University of Technology in Bratislava
1996-1997
Ultrasensitive impedimetric analysis of lectins and viral agglutinins was achieved by a glycan biosensor built on mixed SAM (left) with controlled density (right).
Bladder cancer (BC) belongs to the most frequent types. The diagnostic process is still long and costly, with a high percentage of false-positive or -negative results. Due cost lack effectiveness, older methods need be supplemented replaced by newer more reliable method. In this regard, proteins glycoproteins pose potential.
A new concept of a composite transducer for amperometric biosensors based on the use solid substance with amphiphilic character (called binding matrix, SBM) is presented. The electrochemical properties transducers prepared five different SBMs and characteristics performance SBM-based glucose sensors by three methods are described. Biosensor stability evaluated discussed. biosensor was used determination in wine, yielding results which were consistent those obtained commercially available...
A novel cationic polymer poly(N,N-dimethyl-N-[3-(methacroylamino) propyl]-N-[2-[(2-nitrophenyl)methoxy]-2-oxo-ethyl]ammonium chloride) is synthesized by free-radical polymerization of N-[3-(dimethylamino)propyl] methacrylamide and subsequent quaternization with o-nitrobenzyl 2-chloroacetate. The photolabile carboxymethyl pendant moiety transformed to the zwitterionic carboxybetaine form upon irradiation at 365 nm. This feature used condense and, light irradiation, release double-strand DNA...
We present the innovative concept of a LFA using lectins in role biorecognition element for glycoprofiling biomarkers.
Background: Aberrant glycosylation is a hallmark of cancer and thereby has an excellent potential for the discovery novel biomarkers. Impairments in glycan composition lipoproteins impact their functional properties can be associated with various diseases, including cancer. This research still its infancy; however, it lead to development new diagnostic disease stratification approaches as well therapeutic strategies. Therefore, we aimed evaluate anomalies O-glycosylation apolipoprotein C-III...
Chronic kidney disease (CKD) is a global health concern affecting approximately one billion individuals worldwide. End-stage (ESKD), the most severe form of CKD, often accompanied by anemia. Peritoneal dialysis (PD), common treatment for ESKD, utilizes peritoneum solute transfer but associated with complications including protein loss, transferrin (Tf) key involved in iron transport. This study investigated Tf characteristics ESKD patients compared to healthy using lectin microarray,...
Glycosylation is co- and posttranslational modifications affecting proteins. The glycopattern changes are associated with in biological function involved many diseases including cancer. We present the lectin-based protein microarray method enabling determination of differences glycosylation. involves isolation targeted from samples by immunoprecipitation, spotting multiple into arrays on a slide, incubation set biotinylated lectins, reaction fluorescent conjugate streptavidin, detection...