A5060475002- Nerve Injury and Rehabilitation
- Nerve injury and regeneration
- Spinal Cord Injury Research
- Vagus Nerve Stimulation Research
- Transcranial Magnetic Stimulation Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Botulinum Toxin and Related Neurological Disorders
- Cellular Mechanics and Interactions
- Neuroscience and Neural Engineering
- Peripheral Nerve Disorders
- Anesthesia and Pain Management
- Spine and Intervertebral Disc Pathology
- Orthopedic Surgery and Rehabilitation
- Cerebral Palsy and Movement Disorders
- Elbow and Forearm Trauma Treatment
- Muscle activation and electromyography studies
- Reconstructive Surgery and Microvascular Techniques
- Fault Detection and Control Systems
- 3D Printing in Biomedical Research
Center for Excellence in Brain Science and Intelligence Technology
2023-2024
Chinese Academy of Sciences
2023-2024
Huashan Hospital
2018-2023
Fudan University
2018-2023
Jingzhou Central Hospital
2023
Guangdong University of Petrochemical Technology
2022
Whether, to what extent, and how the axons in central nervous system (CNS) can withstand sudden mechanical impacts remain unclear. By using a microfluidic device apply controlled transverse stress axons, we determined levels that most explored their instant responses at nanoscale resolution. We found mild triggers highly reversible, rapid axon beading response, driven by actomyosin-II-dependent dynamic diameter modulations. This mechanism contributes hindering long-range spread of...
OBJECTIVEContralateral C7 (CC7) nerve root has been used as a donor for targeted neurotization in the treatment of total brachial plexus palsy (TBPP). The authors aimed to study contribution innervation specific upper-limb muscles and explore utility recipient management TBPP.METHODSThis was 2-part investigation. 1) Anatomical study: dissected its individual branches were traced 5 embalmed adult cadavers bilaterally. 2) Clinical series: 6 patients with TBPP underwent CC7 transfer middle...
Restoring limb movements after central nervous system injury remains a substantial challenge. Recent studies proved that crossing nerve transfer surgery could rebuild physiological connectivity between the contralesional cortex and paralyzed arm to compensate for lost function brain injury. However, neural mechanism by which this mediates motor recovery still unclear. Here, using clinical mouse model, we showed can restore skilled forelimb in adult mice with unilateral cortical lesion...
In this study, we examined the prognostic factors affecting outcomes following nerve grafting in high radial injuries. Thirty-three patients with injuries at a level distal to first branch triceps and proximal posterior interosseous were retrospectively studied. After follow-up of least 1 year, 24 (73%) obtained M3+ wrist extension, 16 (48%) finger extension only ten (30%) thumb extension. Univariate, multivariate receiver operating characteristic analyses showed that delay repair less than...
Abstract Backgrounds Contralateral cervical seventh (C7) nerve transfer aids motor and sensory recovery in total brachial plexus avulsion injuries (TBPI), but synchronous sensation often persists postoperatively. The mechanism underlying phenomena remain largely unknown. Objective To investigate the role of central plasticity after contralateral C7 transfer. Methods Sixteen right TBPI patients who received for more than 2 years were included. Sensory evaluations included Semmes–Weinstein...
Crossing nerve transfer surgery has been a powerful approach for repairing injured upper extremities in patients with brachial plexus avulsion injuries. Recently, this was creatively applied the clinical treatment of brain injury and achieved substantial rehabilitation paralyzed arm. This functional recovery after suggests that peripheral sensorimotor intervention induces profound neuroplasticity to compensate loss function damage; however, underlying neural mechanism is poorly understood....
Crossing nerve transfer surgery has been a powerful approach for repairing injured upper extremities in patients with brachial plexus avulsion injuries. Recently, this was creatively applied the clinical treatment of brain injury and achieved substantial rehabilitation paralyzed arm. This functional recovery after suggests that peripheral sensorimotor intervention induces profound neuroplasticity to compensate loss function damage; however, underlying neural mechanism is poorly understood....
Abstract Summary Pan et al found that actomyosin-II-driven radial contractility underpins the resilience of central axons to mild mechanical stress by suppressing propagation and firing injurious Ca 2+ waves. Boosting actomyosin-II activity alleviates axon degeneration in mice with traumatic brain injury. Traumatic injury (TBI) remains a significant unmet health challenge. However, our understanding how neurons, particularly their fragile axons, withstand abrupt impacts within nervous system...