A5019781350- Breast Lesions and Carcinomas
- Cancer Risks and Factors
- Neutropenia and Cancer Infections
- Immune cells in cancer
- interferon and immune responses
- Acute Myeloid Leukemia Research
- RNA regulation and disease
- Male Breast Health Studies
- Immune Response and Inflammation
- Childhood Cancer Survivors' Quality of Life
- Vaccine Coverage and Hesitancy
- Rocket and propulsion systems research
- Insect and Pesticide Research
- Agricultural economics and policies
- Child and Adolescent Health
- Mycotoxins in Agriculture and Food
- Engineering and Material Science Research
- Military and Defense Studies
- Acute Lymphoblastic Leukemia research
- Lipid metabolism and biosynthesis
- Pneumonia and Respiratory Infections
- Cancer Cells and Metastasis
- Sepsis Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Biochemical and Molecular Research
McMaster University
2023-2024
Oklahoma State University Oklahoma City
2024
Oklahoma State University
2024
Texas Tech University
1999-2021
Children's Mercy Hospital
2012
Imperial College London
2003-2006
The University of Texas MD Anderson Cancer Center
2002-2003
The Dialogue
2003
Queen Elizabeth Hospital
2000
Chinese University of Hong Kong
2000
Objective: The synthesis of appropriate extracellular matrix by cells in tissue engineered heart valve constructs will be important for the maintenance cusp integrity and function. We have examined compared capacity mesenchymal stem to synthesise collagen response stretch comparison with native aortic interstitial cells.
To describe patients' perspectives concerning the use of humor in their care and recovery.Descriptive.Community-based.Nine women with a diagnosis breast cancer.Open-ended interviews were conducted participants to identify humor, its influence on spirituality, perceptions how nurses caring for them during treatment cancer.The as coping skill.The narrative data revealed three major categories, each five six themes illuminating factor, relationship between nursing, spirituality.Participants...
The individual and combined effects of ochratoxin A (OA) cyclopiazonic acid (CPA) were evaluated in Petersen x Hubbard broiler chickens from 1 d to 3 wk age. experimental design was a 2 factorial with treatments 0 2.5 mg OA/kg feed 34 CPA/kg feed. Production performance, serum biochemistry, gross pathological observations evaluated. Body weight gain reduced (P < 0.05) by OA, CPA, OA-CPA combination at the end wk. Ochratoxin significantly increased relative kidney concentrations uric...
Cancer remains the leading cause of death worldwide with approved oncology drugs continuing to have heterogenous patient responses and accompanied adverse effects (AEs) that limits effectiveness. Here, we examined >100 FDA-approved in context stemness using a surrogate model transformed human pluripotent cancer stem cells (CSCs) vs. healthy (hSCs) capable distinguishing abnormal self-renewal differentiation. Although proportion these had no (inactive), larger portion affected CSCs (active),...
We systematically investigate functional and molecular measures of stemness in patients with acute myeloid leukemia (AML) using a cohort 121 individuals. confirm that the presence leukemic stem cells (LSCs) detected through vivo xenograft transplantation is associated poor survival. However, measurement progenitor (LPCs) vitro colony-forming assays provides an even stronger predictor overall event-free LPCs not only capture patient-specific mutations but also retain serial re-plating...
Despite most acute myeloid leukemia (AML) patients entering remission following chemotherapy, outcomes remain poor due to surviving leukemic cells that contribute relapse. The nature of these enduring is poorly understood. Here, through temporal single-cell transcriptomic characterization AML hierarchical regeneration in response we reveal a cell population: enriched (RECs). RECs are defined by CD74/CD68 expression, and although derived from stem (LSCs), devoid stem/progenitor capacity....
RNA virus-induced excessive inflammation and impaired antiviral interferon (IFN-I) responses are associated with severe disease. This innate immune response, also referred to as "dysregulated immunity" is caused by viral single-stranded (ssRNA)- double-stranded-RNA (dsRNA)-mediated exuberant protein-induced IFN antagonism. However, key host factors the underlying mechanism driving RNA-mediated dysregulated immunity poorly defined. Here, using ssRNA dsRNA mimics, which activate toll-like...
RNA virus induced excessive inflammation and impaired antiviral interferon (IFN-I) responses are associated with severe disease. This innate immune response, also referred to as 'dysregulated immunity,' is caused by viral single-stranded (ssRNA) double-stranded-RNA (dsRNA) mediated exuberant protein-induced IFN antagonism. However, key host factors the underlying mechanism driving RNA-mediated dysregulated immunity poorly defined. Here, using ssRNA dsRNA mimics, which activate toll-like...
Visceral obesity may be a driving factor in nonalcoholic fatty liver disease (NAFLD) development. Previous studies have shown that the omega-3 polyunsaturated acid, eicosapentaenoic acid (EPA), ameliorates high-fat (HF) fed male, C57Bl/6 mice at thermoneutral conditions, independent of uncoupling protein 1 (UCP1). Our goals herein were to investigate sex-dependent mechanisms EPA livers wild type (WT) and UCP1 knockout (KO) male female HF diet (45% kcal fat; WT-HF, KO-HF) with or without...
Objective: To compare the immunization certificate submission rate for kindergarten school children on Central Coast of New South Wales 1994 and 1995; to contact individual parents with incomplete or missing certificates by issuing a personalised reminder letter, measuring their response. Methodology: Seventy schools were surveyed. Immunization documentation 4177 enrolments in 1995 assessed. Children unknown status identified. letters sent that The recorded any additional submitted. Results:...
ABOUT THE AUTHOR Paige Johnson, MSN, ANP, PNP. is a certified adult and pediatric nurse practitioner. At the time this article was written, she practitioner at The University of Texas MD Anderson Cancer Center for Department Breast Medical Oncology in Houston, Tx. Short Communications enables clinicians to trade practice tips, experiences, information, research findings. Communication articles are not reviewed by editorial review board; goal allow free dialogue among journal readers.