A5040793414- interferon and immune responses
- Virus-based gene therapy research
- Cytomegalovirus and herpesvirus research
- Plant Parasitism and Resistance
- Viral Infections and Immunology Research
- Gut microbiota and health
- Herpesvirus Infections and Treatments
- Lung Cancer Treatments and Mutations
- Genetics, Bioinformatics, and Biomedical Research
- Immune Cell Function and Interaction
- Salivary Gland Tumors Diagnosis and Treatment
- Plant Virus Research Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Epigenetics and DNA Methylation
- Machine Learning in Bioinformatics
- Plant-Microbe Interactions and Immunity
- Liver Disease Diagnosis and Treatment
BGI Group (China)
2025
University of Chinese Academy of Sciences
2025
BGI Research
2025
China Jiliang University
2024
Qinghai University
2024
Abstract Fulminant myocarditis (FM) is a severe inflammatory condition of the myocardium that often results in sudden death, particularly young individuals. In this study, we employed single-nucleus and spatial transcriptomics to perform comprehensive analysis coxsackievirus B3 (CVB3)-induced FM A/J mice, spanning seven distinct time points pre- post-treatment. Our findings reveal mesothelial cells play critical role early stage by acting as primary targets for CVB3 infection. This triggers...
Abstract The gut microbiota influences host immunity and metabolism, changes in its composition function have been implicated several non‐communicable diseases. Here, comparing germ‐free (GF) specific pathogen‐free (SPF) mice using spatial transcriptomics, single‐cell RNA sequencing, targeted bile acid metabolomics across multiple organs, we systematically assessed how the microbiota's absence affected organ morphology, immune homeostasis, acid, lipid metabolism. Through integrated analysis,...
Abstract Virus-induced drought tolerance presents a fascinating facet of biotic–abiotic interaction in plants, yet its molecular intricacies remain unclear. Our study shows that cowpea mild mottle virus (CPMMV) infection enhances common bean (Phaseolus vulgaris) plants through virus-derived small interfering RNA (vsiRNA)-activated autophagy pathway. Specifically, 21 nt vsiRNA originating from the CPMMV Triple Gene Block1 (TGB1) gene targeted 5′ untranslated region (UTR) host Teosinte...
To analyze the expression of SPAG5 in gastric cancer tissues and its regulatory roles cell growth.