A5082978202- Cellular Mechanics and Interactions
- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- thermodynamics and calorimetric analyses
- Force Microscopy Techniques and Applications
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Protein Structure and Dynamics
- Esophageal Cancer Research and Treatment
- Head and Neck Cancer Studies
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- 3D Printing in Biomedical Research
- Head and Neck Surgical Oncology
- Spaceflight effects on biology
- Molecular Junctions and Nanostructures
- Polymer Surface Interaction Studies
- Radiomics and Machine Learning in Medical Imaging
- Blood properties and coagulation
- Advanced Polymer Synthesis and Characterization
- Cell Image Analysis Techniques
- Helicobacter pylori-related gastroenterology studies
- Biocrusts and Microbial Ecology
Leipzig University
2021-2024
Fraunhofer Institute for Cell Therapy and Immunology
2023
Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde
2023
University Hospital Leipzig
2022
Abstract Established model theories, developed to capture the mechanical behavior of soft, complex materials composed semiflexible polymers, assume that entropic interactions between filaments are primarily responsible for determining response. In recent studies, generally accepted tube has been challenged in terms this basic assumption about filament–filament interactions, but also because its predictions regarding frequency dependence elastic modulus intermediate regime. A central question...
Abstract Solvent conditions are unexpectedly sufficient to drastically and reversibly slow down cells. In vitro on the molecular level, protein–solvent interactions change in presence of heavy water (D 2 O) its stronger hydrogen bonds. Adding D O cell medium living cells increases intracellular viscosity. While morphology phenotype remain unchanged, cellular dynamics transform into motion a changeable manner. This is exemplified slowdown proliferation migration, which caused by reversible...
Abstract Background The purpose of the study was to conduct a comprehensive genomic characterization gene alterations, microsatellite instability (MSI), and tumor mutational burden (TMB) in submucosal-penetrating (Pen) early gastric cancers (EGCs) with varying prognoses. Methods Samples from EGC patients undergoing surgery 10-year follow-up data available were collected. Tissue alterations characterized using Trusight Oncology panel (TSO500). Pathway (PI) scores for selection 218 GC-related...
We introduce a new DNA-based approach to systematically investigate the bulk properties of crosslinked semiflexible polymer networks as model for natural biopolymer networks, by stepwise altering binding affinity crosslinkers.
Detection of p16 through immunohistochemistry (IHC) is the standard for determining HPV status tumor according TNM eighth edition released in 2017 and has become crucial oropharyngeal squamous cell carcinomas (OPSCC) with direct impact on staging prognostication. In recent years, detection DNA mouthwashes been proposed as a noninvasive alternative, both OPSCCs other head neck (HNSCCs). However, prospect using to monitor response therapy unclear. To evaluate effect curative DNA, we performed...
Insights and discoveries in complex biological systems, e.g. for personalized medicine, are gained by the combination of large, feature-rich high-dimensional data with powerful computational methods uncovering patterns relationships. In recent years, autoencoders, a family deep learning-based representation learning, advancing data-driven research due to their variability non-linear power multi-modal integration. Despite success, current implementations lack standardization, versatility,...
Heavy water is known to affect many different biological systems, with the most striking effects observed at cellular level. Many dynamic processes, such as migration or invasion, but also central processes of cell proliferation are measurably inhibited by presence deuterium oxide (D2O). Furthermore, individual deformabilities significantly decreased upon D2O treatment. In order understand origin these effects, we studied entangled filamentous actin networks, a commonly used model system for...
Abstract Established model theories, developed to capture the mechanical behavior of soft complex materials composed semiflexible polymers assume entropic interactions between filaments determine response. In recent studies, general accepted tube has been challenged in terms its basic assumption about filament-filament interactions, but also because predictions regarding frequency dependence elastic modulus intermediate regime. A central question is how molecular and friction network...
In article number 2101840, Jörg Schnauß and co-workers show that heavy water (D2O) reversibly slows down cells, retards cell invasion, drastically impacts mechanics, possibly prolonging storage times for biological materials. The cellular dynamics, which transform into slow motion, can be captured via the time-temperature superposition principle, where temperature is replaced by D2O. Induced changes are fully reversible effects independent of signaling/expression.
Background Effective immune surveillance critically depend on proteins encoded by genes of the major histocompatibility complex, human leukocyte antigen (HLA) alleles. As we recently could demonstrate a link between altered HLA allele and haplotype frequencies in head neck squamous cell carcinoma (HNSCC) related to classical risk factors alcohol tobacco, were interested if findings predictive value our score be replicated HPV-driven (p16-positive high risk-HPV DNA-positive) HNSCC independent...
Hintergrund Eine effektive Immunabwehr hängt entscheidend von Proteinen ab, die Genen des MHC (Haupthistokompatibilitätskomplex), den humanen Leukozyten-Antigen-Allelen, kodiert werden. Da wir zuvor bereits einen Zusammenhang zwischen veränderten HLA-Allel- und Haplotyp-Frequenzen bei HNSCC abhängig klassischen Risikofaktoren wie Alkohol- Nikotinkonsum nachweisen konnten, interessierte uns nun, ob diese Ergebnisse der Vorhersagewert unseres HLA-Scores in HPV-getriebenen (p16-positiven, high...