A5035795796- Musculoskeletal pain and rehabilitation
- Genetic Neurodegenerative Diseases
- Microscopic Colitis
- Pain Mechanisms and Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Inflammatory Bowel Disease
- Pain Management and Placebo Effect
- Psychosomatic Disorders and Their Treatments
- Health, psychology, and well-being
- Eosinophilic Esophagitis
- Occupational Health and Safety Research
- Facial Nerve Paralysis Treatment and Research
- Metastasis and carcinoma case studies
- Occupational exposure and asthma
- Anesthesia and Pain Management
- Myofascial pain diagnosis and treatment
- Sleep and related disorders
- Trigeminal Neuralgia and Treatments
- Breast Cancer Treatment Studies
- Occupational Health and Safety in Workplaces
- Pediatric Pain Management Techniques
- Health Systems, Economic Evaluations, Quality of Life
- Thyroid and Parathyroid Surgery
- Traumatic Ocular and Foreign Body Injuries
- Cancer Immunotherapy and Biomarkers
University Medical Center of the Johannes Gutenberg University Mainz
2014-2021
Johannes Gutenberg University Mainz
2014-2021
University of Basel
2013-2014
University of Bern
2009-2012
University Hospital of Bern
2009-2011
BackgroundDiverse psychological factors are involved in the pathophysiology of stress. In order to devise effective intervention strategies, it is important elucidate which play most role association between stress and exacerbation Crohn's disease (CD). We hypothesized that perceived CD would remain after removal mood anxiety components, largely perception.
Objective Violence, accidents and natural disasters are known to cause post-traumatic stress, which is typically accompanied by fear, suffering impaired quality of life. Similar chronic diseases, such events preoccupy the patient over longer periods. We hypothesised that stress could also be caused Crohn's disease (CD), CD specific associated with an increased risk exacerbation. Methods A cohort patients was observed 18 months in various types locations providing gastroenterological...
Hypersensitivity of the central nervous system is widely present in pain patients and recognized as one determinants chronic disability. Electronic pressure algometry often used to explore aspects hypersensitivity. We hypothesized that a simple provocation test with clothes peg provides information on sensitivity compares meaningfully obtained by well-established electronic algometer. "Clinically meaningful" was defined medium (r = 0.3-0.5) or high > 0.5) correlation coefficient according...
Widespread central hypersensitivity and altered conditioned pain modulation (CPM) have been documented in chronic conditions. Information on their prognostic values is limited. This study tested the hypothesis that widespread (WCH) CPM, assessed during phase of low back neck pain, predict poor outcome.A total 169 consecutive patients with or referred to clinic 1 year, were analyzed. Pressure tolerance threshold at second toe time cold pressor test hand WCH. CPM was measured by change...
Social support has been found to be protective from adverse health effects of psychological stress. We hypothesized that higher social would predict a more favorable course Crohn's disease (CD) directly (main effect hypothesis) and via moderating other prognostic factors (buffer hypothesis).Within multicenter cohort study we observed 597 adults with CD for 18 months. assessed using the ENRICHD Support Inventory. Flares, nonresponse therapy, complications, extraintestinal manifestations were...
Objective Ramsay Hunt syndrome (RHS) and Bell palsy (BP) are typically known as facial nerve motor syndromes primarily unilateral. The aim of this study was to challenge assertion, because both conditions also be associated with viruses that affect several nerves. Methods Ten participants RHS, 12 BP, all clinically unilateral, healthy controls were prospectively enrolled. Electrogustometric thresholds measured bilaterally in the areas chorda tympani, glossopharyngeal, major petrosal nerve....
Little is known about the impact of nutrition status on Huntington’s disease (HD) severity.To analyze association nutritional factors with HD severity.Observational, cross-sectional, national multicenter study. Participants were selected from a Spanish cohort patients who participate in European Huntington Disease Network (EHDN). The frequency food consumption, caloric and nutrients intake assessed using validated questionnaires for population, calculated Alimentaci´on Salud, version 2.0,...
Ongoing pain after surgery is a major problem and influences recovery the quality of life patient. Associations between anxiety their impact on postoperative herniated disc have been reported, but results are inconsistent. The aim present longitudinal study was to evaluate predictive value preoperative for ongoing prolonged analgesic intake surgery. 106 patients with lumbar herniation were evaluated in study. Anxiety measured Generalized Disorder 7-Item Scale (GAD-7) before Pain intensity...
Pain drawings are a diagnostic adjunct to history taking, clinical examinations, and biomedical tests in evaluating pain. We hypothesized that somatoform-functional pain, is mirrored distinctive graphic patterns of pain drawings. Our aim was identify the most sensitive specific criteria as tool help identifying compared 62 patients with control group 49 somatic-nociceptive type. All were asked mark their on pre-printed body diagram. An investigator, blinded regard patients' diagnoses,...
Prior findings suggest that women and elderly persons are more sensitive to pressure than men younger persons; however, the magnitudes of these differences substantially inconsistent. We answered question whether higher sensitivity is quantitatively meaningful. Specifically, we investigated if it large enough hamper diagnosis, classification follow-up pain conditions by clinicians.From each age stratum (18-20, 21-30, 31-40, 41-50, 51-60, 61-70, 71-80, >80 years), 40 pain-free were recruited....
Abstract Background The impact of intraoperative frozen section (iFS) analysis on the frequency completion thyroidectomy for management thyroid carcinoma is controversial. Although specialized endocrine centres have published their respective results, there are insufficient data from primary and secondary healthcare levels. aim this study was to analyse utility iFS analysis. Methods In Prospective Evaluation Study Thyroid Surgery (PETS) 2 study, 22 011 operations benign malignant disease...
Objectives. We compared two index screening tests for early diagnosis of functional pain: pressure pain measurement by electronic diagnostic equipment, which is accurate but too specialized primary health care, versus peg testing, cost-saving and more easily manageable unknown sensitivity specificity. Early distinction (altered perception; nervous sensitization) from neuropathic or nociceptive improves management. Methods. Clinicians blinded the assessed reference standard this...
We assessed the feasibility of an epidemiological study on risk radiation-related lens opacities among interventional physicians in Germany. In a regional multi-centre pilot associated with European project, we tested recruitment strategy, questionnaire work history for latter dosimetry calculation and endpoint assessment. 263 129 non-exposed colleagues were invited. Questionnaires eligibility criteria, factors cataract, relating to occupational exposure ionising radiation, including details...
Patients with Huntington's disease (HD) are at risk for body weight loss and increased institutionalization, morbidity, mortality. The aim of this study was to determine the factors associated low mass index (BMI) in patients HD.In national, observational, cross-sectional European Disease Network, frequency food consumption, calories, nutrient intake HD assessed using questionnaires validated Spanish population were calculated software package Alimentación Salud (Diet Health), version 2.0....
While quality of life (QoL) is a well-recognised outcome measure Crohn disease (CD) activity, its influence on other measures, including exacerbation CD poorly understood. If QoL measures were to be associated with intestinal inflammatory they might useful for early detection subclinical flares.We hypothesised that low subsequent flares.A cohort 318 adult patients was observed 1 year after assessment baseline characteristics. Data collected in Swiss university hospitals, regional hospitals...
Aims: Pain drawing (PD) is a common method in the assessment of pain patients. Our aim was to find graphic criteria which help distinguish between somatic and somatoform disorder.