A5005089413- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Metastasis and carcinoma case studies
- Cancer-related molecular mechanisms research
- Hepatocellular Carcinoma Treatment and Prognosis
- MicroRNA in disease regulation
- Gastrointestinal Tumor Research and Treatment
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- Wnt/β-catenin signaling in development and cancer
- Inflammatory Biomarkers in Disease Prognosis
- Helicobacter pylori-related gastroenterology studies
- Circular RNAs in diseases
- Renal cell carcinoma treatment
- Cancer, Lipids, and Metabolism
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
2020-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2024
Pfizer (United Kingdom)
2023
Roche (Switzerland)
2023
Novartis (Switzerland)
2023
Jazz Pharmaceuticals (United States)
2023
Validated predictors of sensitivity or resistance to Bevacizumab (Bev) are not available, and Inflammatory Indexes (IIs) has been reported be useful prognostic factors in various malignant solid tumours, including metastatic colorectal cancer (mCRC).To explore the value IIs mCRC patients treated with first-line chemotherapy plus Bev.One hundred eighty-two diagnosed first line Bev were considered for this prospective non-pharmacological study. Neutrophil, lymphocyte, platelet, aspartate...
Circulating tumor DNA predicts prognosis of mCRC patients receiving first-line bevacizumab based-chemotherapy
E-cadherin is a key player in gastric cancer (GC) and germline alterations of CDH1, its encoding gene, are responsible for Hereditary Diffuse Gastric Cancer (HDGC) syndrome. This study aimed at elucidating the role genetic variants DNA methylation CDH1 promoter enhancers regulation gene expression. For this purpose, we analyzed through Next-Generation Sequencing (NGS) series GC cell lines (NCI-N87, KATO-III, SNU-1, SNU-5, GK2, AKG, KKP) corresponding expression levels. By bisulfite genomic...
Abstract Background The purpose of the study was to conduct a comprehensive genomic characterization gene alterations, microsatellite instability (MSI), and tumor mutational burden (TMB) in submucosal-penetrating (Pen) early gastric cancers (EGCs) with varying prognoses. Methods Samples from EGC patients undergoing surgery 10-year follow-up data available were collected. Tissue alterations characterized using Trusight Oncology panel (TSO500). Pathway (PI) scores for selection 218 GC-related...
Abstract Bevacizumab (Bev) plus chemotherapy is a standard first-line treatment in metastatic colorectal cancer (mCRC), however to date no predictive factors of response have been identified. Results our previous analysis on patients enrolled randomized prospective phase III multicenter study (ITACa study) showed value Vascular Endothelial Growth Factor ( VEGF ) polymorphism + 936), 27-nucleotide variable number tandem repeat (VNTR) the endothelial nitric oxide synthase eNOS gene and 894...
Therapeutic management of locally advanced gastric cancer (LAGC) combines surgery with neo-adjuvant (NACT) and adjuvant chemotherapy (ACT). miRNAs have emerged as promising candidates for treatment efficacy prediction, hence, the present study aims at defining therapy response-specific profiles circulating miRNAin LAGC. A prospective cohort 26 LAGC patients scheduled NACT, ACT was considered. Peripheral blood samples were collected prior to (preNACT) after NACT (postNACT) well tumor surgical...
Abstract Bevacizumab (Bev) plus chemotherapy is a standard first-line treatment in metastatic colorectal cancer (mCRC), however to date no predictive factors of response have been identified. Results our previous analysis on patients enrolled randomized prospective phase III multicenter study (ITACa study) showed value Vascular Endothelial Growth Factor ( VEGF ) polymorphism + 936), 27-nucleotide variable number tandem repeat (VNTR) the endothelial nitric oxide synthase eNOS gene and 894...