A5028731046- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Lymphoma Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- CRISPR and Genetic Engineering
- Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Breast Implant and Reconstruction
- Pluripotent Stem Cells Research
- Brain Metastases and Treatment
- Medical Imaging Techniques and Applications
- Digital Radiography and Breast Imaging
- Algal biology and biofuel production
- Global Cancer Incidence and Screening
- Cancer Treatment and Pharmacology
- Esophageal Cancer Research and Treatment
- Viral-associated cancers and disorders
- Colorectal and Anal Carcinomas
- Cancer Genomics and Diagnostics
- BRCA gene mutations in cancer
- HER2/EGFR in Cancer Research
- RNA Research and Splicing
- Metastasis and carcinoma case studies
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
Peking University
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2024
Jiangnan University
2024
Peking Union Medical College Hospital
2020-2022
Wageningen University & Research
2020
Chinese Academy of Sciences
2008-2016
Center for Excellence in Molecular Cell Science
2008-2016
Shanghai Institutes for Biological Sciences
2008-2016
Shandong First Medical University
2013
Shandong Tumor Hospital
2013
Steady-state circular RNAs (circRNAs) have been mapped to thousands of genomic loci in mammals. We studied circRNA processing using metabolic tagging nascent with 4-thiouridine (4sU). Strikingly, the efficiency from pre-mRNA is extremely low endogenously. Additional studies revealed that back-splicing outcomes correlate fast RNA Polymerase II elongation rate and are tightly controlled by cis-elements vivo. Additionally, prolonged 4sU labeling cells shows circRNAs largely processed...
Psychological capital, an intrinsic personal asset, enhances junior nurses' ability to navigate transition and sustain superior job performance. This study aimed classify nurses into distinct psychological capital profiles examine their associations with burnout perceived stress levels.
To develop nomograms to assess prognostic factors for 5-year overall survival (OS) and progression-free (PFS) in locally advanced cervical squamous cell carcinoma (LACSC).Overall, 618 patients with LACSC were included this retrospective analysis. Nomograms OS PFS developed based on Cox proportional hazards regression models. Concordance index (C-index) calibration curves used define the predictive discriminatory capacity of nomogram. A comparison between nomogram International Federation...
To investigate the appropriate timing of radiotherapy (RT) after mastectomy and adjuvant chemotherapy for women with high-risk breast cancer.Post hoc analyses 584 patients stage II III cancer from a randomised controlled clinical trial were performed. All underwent followed by sequential RT. The optimal cut-off values surgery-RT interval (SRI) chemotherapy-RT (CRI) overall survival (OS) determined using hazard ratio continuous predictors. locoregional recurrence (LRR), distant metastasis...
This study employed both response surface methodology (RSM) and artificial neural network (ANN) to optimize the technological conditions for citric acid-assisted extraction of bioactive components from Lonicera caerulea pomace. We optimized contents polyphenols crude polysaccharides in extract based on volume, temperature, time. The ANN model exhibited superior predictability accuracy compared RSM model. Using acid solution with a pH 2 as agent, optimal were solid-to-liquid ratio 1:36, an...
Background and Purpose We investigated the locoregional effect of trastuzumab, determined whether patients with human epidermal growth factor receptor (HER)2-positive breast cancer (BC) treated trastuzumab could achieve comparable efficacy to that HER2-negative BC. Materials Methods This was post hoc analyses data 793 BC from a randomized controlled trial comparing post-mastectomy hypofractionated radiotherapy conventional fractionated radiotherapy. Survival rates were analyzed by...
Ganoderma lucidum is a wildly used medicinal mushroom and has been in East Asia because of its health-benefit effects. G. contains various compounds with different biological activities, which include anti-tumour, anti-viral, anti-malaria effect. Ganoderic acid (GA) triterpenoid from lucidum. The biosynthesis GA induced by stressors including elicitors or signaling molecules, artificially placing would enhance production. In this paper, bioactivities potential applications GAs be focused,...
The aim of this study is to evaluate anatomic lung tumor changes and dosimetric consequences utilizing the deformable daily kilovolt (KV) cone-beam computer tomography (CBCT) image registration. Five patients diagnosed with NSCLC were treated three-dimensional conformal radiotherapy (3D CRT) 10 KV CBCT sets acquired for each patient. Each plan CT imported into registration (DIR) system. was deformed by DIR system a new contour on obtained using auto-contouring function DIR. These contours...
Liver cancer is a devastating disease that has second highest mortality rate worldwide. Although surgical resection or liver transplantation sometimes cures early stage cancer, few therapeutic options are available for advanced-stage highlighting the importance of better understanding to find novel targets. Firstly, clinical features EPS8L3 on RNA-seq dataset The Cancer Genome Atlas (TCGA) database was analyzed, including gene expression levels in tumor tissues comparison with normal as well...
Abstract Background To analyze the patterns of locoregional recurrence in breast cancer patients after mastectomy. Methods The retrospective study included 7073 women with without post-mastectomy radiotherapy: 4604 (65.1%) had pT1–2 N0 disease (low risk); 2042 (28.9%), N1 (intermediate and 427 (6.0%), pT3–4 and/or pN2–3, or neoadjuvant chemotherapy (high risk). distribution cumulative was analyzed. local regional rates were estimated by Kaplan-Meier method, differences compared log-rank...
To investigate the effect of chemotherapy and radiotherapy timing after breast conserving surgery (BCS) on recurrence survival women with early-stage cancer. We retrospectively analyzed 900 patients who underwent BCS followed by both adjuvant radiotherapy. Of these, 488 received first (CT-first group) while other 412 (RT-first group). Locoregional (LRR), distant metastasis (DM), disease-free (DFS), overall (OS) rates were calculated using Kaplan-Meier method further confirmed...
Abstract Background To compare the survival outcomes between breast-conserving surgery (BCS) and modified radical mastectomy (MRM), to investigate role of radiotherapy (RT) in patients with pT1–2N1M0 breast cancer. Methods A total 4262 women T1–2N1M0 cancer treated at two institutions were retrospectively reviewed. 3858 underwent MRM, 832 (21.6%) them received postoperative RT (MRM + RT). 404 BCS plus (BCS All axillary lymph node dissection, while 3.8% had upfront sentinel biopsy. The...
Magnetic resonance imaging (MRI) performs well in the locoregional assessment of extranodal nasal-type NK/T-cell lymphoma (ENKTCL). It's important to assess value multi-modal MRI-based radiomics for estimating overall survival (OS) patients with ENKTCL. Patients ENKTCL a prospectively cohort were systemically reviewed and all pretreatment MRI acquisitioned. An unsupervised spectral clustering method was used identify risk groups radiomic features. A nomogram-revised index (NRI) plus...
Objectives: To investigate the dosimetric advantages of voluntary deep inspiration breath-hold technique assisted by optical surface monitoring system for whole breast irradiation in left cancer after breast-conserving surgery and verify reproducibility acceptability this technique. Methods: Twenty patients with receiving were enrolled prospective phase II study. Computed tomography simulation was performed during both free breathing all patients. Whole plans designed, volumes doses heart,...