A5114243237- Peptidase Inhibition and Analysis
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- HER2/EGFR in Cancer Research
- Legume Nitrogen Fixing Symbiosis
- Bone Tissue Engineering Materials
- Toxoplasma gondii Research Studies
- Autophagy in Disease and Therapy
- Monoclonal and Polyclonal Antibodies Research
- Insect and Pesticide Research
- Zebrafish Biomedical Research Applications
- Plant Growth Enhancement Techniques
- Plant Stress Responses and Tolerance
- TGF-β signaling in diseases
- Extracellular vesicles in disease
- Bee Products Chemical Analysis
- Cell Adhesion Molecules Research
- RNA Interference and Gene Delivery
- Mesenchymal stem cell research
- Magnesium Alloys: Properties and Applications
- Ubiquitin and proteasome pathways
- Connective tissue disorders research
- Insect and Arachnid Ecology and Behavior
- Cellular Mechanics and Interactions
Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione
2023-2025
Ri.MED
2023-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2025
University of Palermo
2023-2024
In the last years, field of nanomedicine and drug delivery has grown exponentially, providing new platforms to carry therapeutic agents into target sites. Extracellular vesicles (EVs) are ready-to-use, biocompatible, non-toxic nanoparticles that revolutionizing delivery. EVs involved in cell–cell communication mediate many physiological pathological processes by transferring their bioactive cargo cells. Recently, nanovesicles from plants (PDNVs) raising interest scientific community due high...
Plant microbial biostimulants application has become a promising and eco-friendly agricultural strategy to improve crop yields, reducing chemical inputs for more sustainable cropping systems. The soil dwelling bacterium Kocuria rhizophila was previously characterized as Growth Promoting Bacteria (PGPB) its multiple PGP traits, such indole-3-acetic acid production, phosphate solubilization capability salt drought stress tolerance. Here, we evaluated by multi-omics approach, the activity of K....
An Mg-based alloy device manufactured via a superplastic forming process (Mg-AZ31+SPF) and coated using hydrothermal method (Mg AZ31+SPF+HT) was investigated as to increase mechanical osteointegration capability. The cell viability osteointegrative properties of alloy-derived Mg AZ31+SPF AZ31+SPF+HT extracts were regarding their effect on human mesenchymal stem cells (hMSCs) (maintained in basal (BM) osteogenic medium (OM)) after 7 14 days treatment. analyzed through metabolic activity...
Solid tumors have a complex extracellular matrix (ECM) that significantly affects tumor behavior and response to therapy. Understanding the ECM's role is crucial for advancing cancer research treatment. This study established an in vitro model using primary cells isolated from rat breast generate three‐dimensional spheroids. Monolayer spheroid cultures exhibited different protein expression patterns, with spheroids presenting increased level of ECM‐related proteins more environment....
Conditioned media harvested from stem cell culturing have the potential to be innovative therapeutic tools against various diseases, due their high content of growth, trophic and protective factors. The evaluation in vivo effects biosafety these products is essential, zebrafish provides an ideal platform for high-throughput toxicological analysis, concurrently allowing minimization use mammalian models without losing reliability. In this study, we assessed biological elicited by exposure...
Apis mellifera ssp. sicula, also known as the Sicilian black honeybee, is a Slow Food Presidium that produces honey with outstanding nutraceutical properties, including high antioxidant capacity. In this study, we used high-resolution proteomics to profile produced by sicula and identify protein classifiers distinguish it from made more common Italian honeybee (Apis ligustica). We profiled proteome of genetically pure ligustica honeybees bred in same geographical area, so chemical...
Ectodomain shedding, which is the proteolytic release of transmembrane proteins from cell surface, crucial for cell-to-cell communication and other biological processes. The metalloproteinase ADAM17 mediates ectodomain shedding over 50 ranging cytokines growth factors, such as TNF EGFR ligands, to signaling receptors adhesion molecules. Yet, sheddome only partly defined functions protease have not been fully characterized. Some substrates (e.g. HB-EGF) are known bind heparan sulfate...
ABSTRACT Ectodomain shedding, which is the proteolytic release of transmembrane proteins from cell surface, crucial for cell‐to‐cell communication and other biological processes. The metalloproteinase ADAM17 mediates ectodomain shedding over 50 ranging cytokines growth factors, such as TNF EGFR ligands, to signalling receptors adhesion molecules. Yet, sheddome only partly defined functions protease have not been fully characterized. Some substrates (e.g., HB‐EGF) are known bind heparan...