A5025230954- Vibrio bacteria research studies
- Pediatric health and respiratory diseases
- Enterobacteriaceae and Cronobacter Research
- Vector-borne infectious diseases
- Toxin Mechanisms and Immunotoxins
- Bartonella species infections research
- Inhalation and Respiratory Drug Delivery
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Antibiotic Use and Resistance
- Pneumonia and Respiratory Infections
Roche (Switzerland)
2018-2024
University of Basel
2014
Numerous bacterial pathogens secrete multiple effectors to modulate host cellular functions. These may interfere with each other efficiently control the infection process. Bartonellae are Gram-negative, facultative intracellular bacteria using a VirB type IV secretion system translocate cocktail of Bartonella effector proteins (Beps) into cells. Based on in vitro models we demonstrate here that BepE protects infected migratory cells from injurious effects triggered by BepC and is required...
Diazabicyclooctanes (DBOs) are an increasingly important group of non β-lactam β-lactamase inhibitors, employed clinically in combinations such as ceftazidime/avibactam. The dose finding is complicated using the traditional pharmacokinetic/pharmacodynamic (PK/PD) index approach, especially if inhibitor has antibiotic effect its own.To develop a novel mechanism-based pharmacokinetic-pharmacodynamic (PKPD) model for ceftazidime/avibactam against Gram-negative pathogens, with potential...
Abstract Background Nacubactam (NAC, OP0595, RG6080) is a novel member of the diazabicyclooctane inhibitor family with dual mode action, acting as β-lactamase and an antibacterial agent by means PBP2 inactivation. NAC restores extends activity β-lactam antibiotics, such meropenem (MEM), when used in combination against variety carbapenem-resistant Enterobacteriaceae (CRE). The first year results ROSCO surveillance study for MEM/NAC contemporary clinical isolates are presented here. Methods...
Summary While commensal bacteria generally respect natural barriers of the human body, pathogens are able to breach epithelia, invade deeper tissue layers and cause life-threatening infections. Pseudomonas aeruginosa , an opportunistic pathogen, is a leading severe hospital-acquired pneumonia, with mortality rates as high 50% in mechanically ventilated patients 1–3 . Effective colonization breaching lung mucosa hallmarks P. pathogenesis 4 Although virulence factors behavioral strategies have...