Scope Curcumin is a natural polyphenol compound with multiple pharmacologic activities. The present study aims to explore the potential therapeutic properties of curcumin on intestinal inflammatory diseases, including its anti‐inflammatory, antioxidant, and anti‐apoptotic properties, as well their associations altered microbiome. Methods Results DSS, i.e., Dextran Sulfate Sodium, (3%) administered C57BL/6J mice in drinking water daily for 6 days DSS groups. Then, groups are orally 50 or 150...

Recently, the emergence of a NADC34-like porcine reproductive and respiratory syndrome virus (PRRSV), which causes large number abortions in swine herds, has raised great concern China. In this study, PRRSV variant strain, PRRSV/CN/FJGD01/2021, evolved from recombination between NADC30-like, NADC34-like, JXA1-like viruses was isolated Fujian province 2021, its pathogenicity piglets examined. Animal experiments demonstrated that PRRSV/CN/FJGD01/2021 infection could induce 100% morbidity cause...

The gut–liver axis has emerged as a key player in the progression of non-alcoholic fatty liver disease (NAFLD). Sulforaphane (SFN) is bioactive compound found cruciferous vegetables; however, it not been reported whether SFN improves NAFLD via axis. C57BL/6 mice were fed high-fat and high-fructose (HFHFr) diet, with or without gavage at doses 15 30 mg·kg−1 body weight for 12 weeks. results showed that reduced gain, hepatic inflammation, steatosis HFHFr mice. altered composition gut microbes....

Adenosine-to-inosine (A-to-I) RNA editing, mediated by metazoan ADAR enzymes, is a prevalent post-transcriptional modification that diversifies the proteome and promotes adaptive evolution of organisms. The Drosophila Adar gene has an auto-recoding site (termed S>G site) forms negative-feedback loop stabilizes global editing activity. However, evolutionary trajectory in many other insects remains largely unknown, preventing us from deeper understanding on significance this auto-editing...

Abstract Background Lice (Psocodea: Phthiraptera) are one important group of parasites that infects birds and mammals. It is believed the ancestor parasitic lice originated on ancient avian host, mammals acquired these via host-switching from birds. Here we present first chromosome-level genome Menopon gallinae in Amblycera (earliest diverging lineage lice). We explore transition louse to at genomic level by identifying numerous idiosyncratic variations. Results The assembled 155 Mb length,...

The control region (CR) of the mitochondrial genome (mitogenome) represents a major noncoding fragment with several special structural features that are thought to be responsible for initiation mitogenome transcription and replication. However, few studies have revealed evolutionary patterns CR in phylogenetic context. Here, we explain characteristics evolution Tortricidae, inferred from mitogenome-based phylogeny. first complete mitogenomes genera Meiligma Matsumuraeses were sequenced. Both...

Abstract Background C-to-U RNA editing in plants is believed to confer its evolutionary adaptiveness by reversing unfavorable DNA mutations. This “restorative hypothesis” has not yet been tested genome-wide. In contrast, A-to-I insects like Drosophila and honeybee already known benefit the host increasing proteomic diversity a spatial-temporal manner (namely “diversifying hypothesis”). Methods We profiled editomes of multiple tissues Arabidopsis thaliana , melanogaster Apis melifera ....

Deltacoronavirus is the last identified Coronaviridae subfamily genus. Differing from other coronavirus (CoV) genera, which mainly infect birds or mammals, deltacoronaviruses (δ-CoVs) reportedly both animal types. Recent studies show that a novel δ-CoV, porcine deltacoronavirus (PDCoV), can also calves and chickens with potential to humans, raising possibility of cross-species transmission δ-CoVs. Here, we explored deep phylogenetic history Virus-host cophylogenetic analyses showed δ-CoVs...

Abstract Diallyl trisulfide (DATS) is a bioactive compound in garlic. It has been reported to ameliorate obesity by preventing adipogenesis and lipogenesis white adipose tissue. But we found DATS could also activate brown tissue (BAT) high‐fat diet (HFD)‐fed mice, suggesting another pathway obesity. To explore the mechanism of activating BAT, mice fed with HFD were treated DATS. The results showed that significantly activated BAT regulated gut microbiota. Next, microbiota transplantation...

Adenosine-to-inosine (A-to-I) RNA editing is the most prevalent modification in nervous systems of metazoans. To study biological significance editing, we first have to accurately identify these events from transcriptome. The genome-wide identification sites remains a challenging task. In this review, will introduce occurrence, regulation, and importance A-to-I then describe established bioinformatic procedures difficulties accurate sit esespecially small sized non-model insects. brief, (1)...

Calliptamus italicus L. is an important pest on the desert and semidesert steppes along Sino-Kazakh border. To elucidate molecular mechanism of its continuous outbreaks, we studied 11 different geographic populations C. to determine: 1) complete sequences entire mitochondrial cytochrome oxidase subunit I (COI) II (COII) genes, 2) performed genetic diversity, differentiation, gene flow, variation analyses. Of populations, Yining County (YNX) population had highest haplotype diversity Pi...

To obtain more information of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) transmission via faeces in/between farms, 360 swine faecal samples were randomly collected from different farms in China 2017 to 2019. Sixty-two ORF5 genes amplified by PCR 120 positive identified real-time RT-PCR further characterized sequencing. Phylogenetic analysis based on the gene revealed that these strains can be divided into four lineages: lineage 1 (NADC30-like), 3 (QYYZ-like), 5.1...

Diallyl trisulfide (DATS) is a bioactive compound in garlic. The anti-obesity effect of garlic oil has been reported, but the role and mechanism DATS preventing obesity remain to be explored.Studies with high-fat-diet-induced obese mice 3T3-L1 adipocytes are performed. results show that significantly reduces lipid accumulation repairs disordered metabolism vivo by restraining adipogenesis lipogenesis, promoting lipolysis fatty acid oxidation white adipose tissue. In cells, plays different...

The porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most important pathogens causing substantial economic losses to Chinese swine industry. In this study, we analyzed complete genome sequences four PRRSV isolates (PRRSV2/CN/SS0/2020, PRRSV2/CN/SS1/2021, PRRSV2/CN/L3/2021, PRRSV2/CN/L4/2020) isolated from a single pig farm 2020 2021. genomes were 14,962-15,023 nt long, excluding poly (A) tails. Comparative analysis showed that shared 93.2-98.1% homology they had no...

The trypsin inhibitor (TI) is one of the most important anti-nutritive elements in soybeans. As a new nonthermal technology, dielectric-barrier discharge (DBD) cold plasma has attracted increasing attention food processing. In this research, we investigated effect treatment on soybean content and its structure, evaluated TI toxicity safety degradation products after with DBD technology vitro vivo, applied to milk, which was analyzed for quality. Using statistical analysis Student’s t-test,...

Intestinal inflammation is a key determinant of intestinal and systemic health, when our intestines are damaged, there disruption the barrier, which in turn induces inflammatory response. However, etiology pathogenesis diseases intestine still not fully understood. Artemether (ART), one artemisinin derivatives, has been widely used to treat malaria. Nevertheless, effect ART on remains unclear. The present study intended elucidate potential mechanism diet-induced injury. A high-fat...

Animal mitochondrial (mt) genomes are typically double-strand circular DNA molecules, but diverse structural variations have been widely found in multiple groups. In parasitic lice (Phthiraptera), the structure of mt varies remarkably across all five suborders. this study, we reported complete genome a chicken body louse, Menacanthus cornutus, which has typical single chromosome and drastic gene rearrangements. This is 15,693 bp length, consisting 13 protein-coding genes, 23 tRNA 2 rRNA...

The Hybrid Single Particle Lagrangian Integrated Trajectory Model and meteorological graphics software (Grads ArcGIS) were used to analyze source areas migratory trajectories of a population Locusta migratoria (L.) (Orthoptera: Acrididae) in the Tacheng region Xinjiang, China that borders with eastern Kazakhstan. these locusts migrating into are distributed near Lake Alakol, Zaisan, Balkhash, Irtysh River, Ayaguz River Locusts follow nine their invasion Tacheng. On respective migration...