A5104167300- Pregnancy and preeclampsia studies
- Cancer-related molecular mechanisms research
- PI3K/AKT/mTOR signaling in cancer
- RNA modifications and cancer
- MicroRNA in disease regulation
- Muscle Physiology and Disorders
- Reproductive System and Pregnancy
- Extracellular vesicles in disease
- RNA regulation and disease
- Birth, Development, and Health
- Mitochondrial Function and Pathology
- RNA Research and Splicing
- Autophagy in Disease and Therapy
- Ubiquitin and proteasome pathways
- Sirtuins and Resveratrol in Medicine
- Circular RNAs in diseases
- Inflammasome and immune disorders
- Ginseng Biological Effects and Applications
- Colorectal Cancer Treatments and Studies
- Photoreceptor and optogenetics research
- Yersinia bacterium, plague, ectoparasites research
- Plant Physiology and Cultivation Studies
- Pharmacological Effects of Natural Compounds
- Bacteriophages and microbial interactions
- DNA Repair Mechanisms
Kunming Medical University
2025
Ningxia Center for Diseases Prevention and Control
2024
Ningxia Medical University
2024
Nanfang Hospital
2019-2023
Southern Medical University
2019-2023
Yunnan Agricultural University
2023
Chinese Academy of Agricultural Sciences
2023
University of Oxford
2023
Gansu University of Traditional Chinese Medicine
2022
University of Utah
2020
Accumulating evidence suggests that the pathogenesis of preeclampsia involves poor placentation caused by insufficient trophoblast invasion and impaired uterine spiral artery remodeling, yet underlying molecular mechanism remains unclear. We carried out transcriptome profiling on placentae from preeclamptic patients normal subjects, identified about four hundred long non-coding RNAs differentially expressed in with early-onset severe preeclampsia. Here, we report our identification lncRNA...
As a process of aging, skeletal muscle mass and function gradually decrease. It is reported that ginsenoside Rb1 Rb2 play role as AMP-activated protein kinase activator, resulting in regulating glucose homeostasis, reduces oxidative stress aged muscles through activating the phosphatidylinositol 3-kinase/Akt/Nrf2 pathway. We examined effects on differentiation stem cells myotube formation. C2C12 myoblasts treated with and/or were differentiated induced to formation, followed by...
Preeclampsia is believed to be caused by impaired placentation with insufficient trophoblast invasion, leading uterine spiral artery remodeling and angiogenesis. However, the underlying molecular mechanism remains unknown. We recently carried out transcriptome profiling of placental long noncoding RNAs (lncRNAs) identified 383 differentially expressed lncRNAs in early-onset severe preeclampsia. Here, we are reporting our identification lncRNA INHBA-AS1 as a potential causal factor...
Chemoresistance is the major cause of chemotherapy failure in patients with colorectal cancer (CRC). Protein tyrosine kinase 6 (PTK6) aberrantly overexpressed clinical CRC tissues undergoing chemotherapy. We studied if PTK6 contributed to chemoresistance human and mice.We obtained tissue samples from measured expression by immunohistochemistry. Gain- loss-of-function assays were performed study biological functions PTK6. constructed FLAG-tagged wild type (WT), kinase-dead,...
Mechanical stress regulates development by modulating cell signaling and gene expression. However, the cytoplasmic components mediating mechanotransduction remain unclear. In this study, elimination of muscle contraction during chicken embryonic resulted in a reduction activity mammalian target rapamycin (mTOR) cartilaginous growth plate. Inhibition mTOR led to significant inhibition chondrocyte proliferation, cartilage tissue growth, expression chondrogenic genes, including Indian hedgehog...
While cationic antimicrobial peptides (AMPs) are extensively studied for antitumor effects, anionic AMPs remain underexplored. Notably, no amphibian-derived cathelicidins with activity have been reported. This study identifies Boma-CATH, a novel cathelicidin (net charge-3) from Bombina maxima skin, which suppresses melanoma growth in mice and triggers pyroptosis-like morphological changes A375 cells via the NLRP3/Caspase-1/GSDMD pathway. Further investigation revealed that ROS played crucial...
Abstract mTOR is a nutrient‐sensing protein kinase that regulates numerous cellular processes. Our prior studies using the inhibitor, rapamycin, indicate an important role for in chondrogenesis. We extended our observations to physiological, vivo model of bone growth, direct infusion rapamycin into proximal tibial growth plates rabbits. Rapamycin or DMSO vehicle was infused directly by osmotic minipump 8 weeks. Tibial followed radiographically. At end experiment, were recovered histological...
Although mutations in the phosphoinositide 3-kinase catalytic subunit (PIK3CA) are common breast cancer, PI3K inhibitors alone have shown modest efficacy. We sought to identify additional pathways altered PIK3CA-mutant tumors that might be targeted combination with inhibitors. generated two transgenic mouse models expressing human PIK3CA-H1047R- and -E545K hotspot-mutant genes mammary gland evaluated their effects on development tumor formation. Molecular analysis identified these mutant...
Valuable scientific results on biomedicine are very rich, but they widely scattered in the literature. Topic modeling enables researchers to discover themes from an unstructured collection of documents without any prior annotations or labels. In this paper, taking ginseng as example, biological dynamic topic model (Bio-DTM) was proposed conduct a retrospective study and interpret temporal evolution research ginseng. The system Bio-DTM mainly includes four components, pre-processing,...
Abstract Hydroxytyrosol (HT), a primary phenolic antioxidant in olive oil, can afford protection from oxidative stress (OS) different cells, including skin cells. In particular, it regulates several inflammation‐associated processes as well improving the defense system. However, there is no information about HT used treatment of hair loss. This work aimed at exploring potential protective actions against OS rat dermal papilla After treatment, related expression protein and messenger RNA were...
Advanced oxidation protein products (AOPPs) can trigger NADPH oxidase (NOX) and lead to the production of reactive oxygen species (ROS) in pathophysiology rheumatoid arthritis (RA). Hydroxytyrosol (HT) is a phenolic composite olive oil that has antioxidant anti‑inflammatory effects enhances autophagy. Early research revealed HT activate silent information regulator 1 (SIRT1) pathway induce autophagy alleviate cartilage inflammatory response caused by H2O2. However, whether attenuate...
Abstract Background Substantial studies have demonstrated that oxidative stress placenta and endothelial injury are considered to inextricably critical events in the pathogenesis of preeclampsia (PE). Systemic inflammatory response dysfunction induced by circulating factors released from placentae. As a novel biomarker stress, advanced oxidation protein products (AOPPs) levels strongly correlated with PE characteristics. Nevertheless, molecular mechanism underlying effect is still largely...
Skeletal muscle satellite cells (SMSCs), which are highly multifunctional muscle-derived stem cells, play an essential role in myogenesis and regeneration. Here, the transcriptional profile of SMSCs during proliferation differentiation were constructed using RNA-Seq method. A total 1954 differentially expressed genes (DEGs) 1092 alternative splicing (DAGs) identified including 1288 upregulated as well 666 downregulated genes. GO KEGG analyses showed that DEGs DAGs enriched MAPK...
Abstract Background and purpose: Gastric cancer (GC) is the fifth most common third leading cause of cancer-related deaths worldwide. CD73 has been found to be overexpressed in a variety cancers including GC associated with poor prognosis. However, its specific mechanisms regulating progression are not sufficiently clear. In this study, we aimed investigate function explore upstream downstream molecular mechanisms. Methods: Immunohistochemistry (IHC) western blotting were used detect protein...
Since 2019, the incidence of anthrax in Ningxia Hui Autonomous Region has increased significantly compared with previous years, so this situation region not only had a detrimental impact on public health, but also inflicted significant economic repercussions. Therefore, we conducted molecular epidemiological study 20 strains from 2019-2023 isolates. This investigated origin
Patients with preeclampsia display a spectrum of onset time and severity clinical presentation, yet the underlying molecular bases for early-onset late-onset subtypes are not known. Since root cause PE is thought to be located in placentae, we carried out RNA-seq on 65 high-quality placenta samples, including 33 from 30 patients 32 control subjects, search features. We identified two functionally distinct sets dysregulated genes major subtypes: metabolism-related genes, notably transporter...