A5034411676- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Mast cells and histamine
- Amino Acid Enzymes and Metabolism
- Ion channel regulation and function
- Pharmacological Effects and Toxicity Studies
- Receptor Mechanisms and Signaling
- Near-Field Optical Microscopy
- Advanced Fluorescence Microscopy Techniques
- Neurological disorders and treatments
- Healthcare Systems and Practices
- Health, Medicine and Society
- Pharmacological Receptor Mechanisms and Effects
- Memory and Neural Mechanisms
- Olfactory and Sensory Function Studies
- Chemical Synthesis and Analysis
- Glycogen Storage Diseases and Myoclonus
- Diabetes and associated disorders
- Drug Transport and Resistance Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Trauma and Emergency Care Studies
- Blood groups and transfusion
- Neuroinflammation and Neurodegeneration Mechanisms
- Optical Coatings and Gratings
- Plasmonic and Surface Plasmon Research
Université Paris Cité
2015-2024
Institut de Psychiatrie et Neurosciences de Paris
2021-2024
Centre National de la Recherche Scientifique
2021-2024
SPPIN - Saints-Pères Paris Institute for Neurosciences
2021-2024
Bar-Ilan University
2022
NanoScale Corporation (United States)
2022
Université Paris-Saclay
2022
École Normale Supérieure Paris-Saclay
2022
Inserm
1995-2015
Délégation Paris 5
2015
Histamine potentiates activation of native and recombinant <i>N</i>-methyl-d-aspartate receptors (NMDARs), but its mechanisms action physiological functions in the brain remain controversial. Using four different models, we have further investigated histamine-induced potentiation various NMDAR-mediated responses. In single cultured hippocampal neurons, histamine potentiated NMDA currents. It also NMDA-induced increase intracellular calcium absence, as well with saturating concentrations,...
Summary: Purpose : The objective of this study was to evaluate the effect a new antiseizure drug, retigabine (D‐23129; N ‐(2‐amino‐4‐[fluorobenzylamino]‐phenyl) carbamic acid ethyl ester) on low‐Mg 2+ ‐induced epileptiform discharges in rat vitro. Methods Three types (recurrent short hippocampus, seizure‐like events, and late recurrent entorhinal cortex) were elicited combined cortex‐hippocampal slices by perfusion with ‐artificial cerebrospinal fluid (ACSF). antiepileptic properties...
Abstract After peripheral nerve injury microglial reactivity change in the spinal cord is associated with an early activation of Janus kinase ( JAK )/ STAT 3 transduction pathway whose blockade attenuates local inflammation and pain hypersensitivity. However, consequences / 3‐mediated signaling on neighboring cells are unknown. Using vitro paradigm we assessed impact activity functional characteristics astrocytes neurons. Purified rat primary microglia was stimulated classical activator...
Abstract The modulation of histamine neuron activity by various non‐competitive NMDA‐receptor antagonists was evaluated changes in tele ‐methylhistamine ( t ‐MeHA) levels and histidine decarboxylase hdc ) mRNA expression induced rodent brain. NMDA open‐channel blockers phencyclidine (PCP) MK‐801 enhanced ‐MeHA mouse brain 50–60%. Ifenprodil, which interacts with polyamine sites NR2B‐containing receptors, had no effect. PCP also increased the rat tuberomammillary nucleus. enhancement elicited...
This study attempted to clarify the role of histamine H
Abstract The characterization of ultrathin transparent films is paramount for various optoelectronic materials, coatings, and photonics. However, characterizing such thin layers difficult it requires specialized clean‐room equipment trained personnel. Here, a contact‐less, all‐optical method introduced validated nanometric using far‐field optics. A series nanometric, smooth, homogeneous layered samples are fabricated first, alternating spacer fluorescent in controlled manner. Fluorescence...
Transporter confortablement les blessés vite et loin, est un des problèmes aux diflicultés plus grandes, car du transport pet résulter l'aggravation de la blessure dépendre le succès l'intervention chirurgicale.On sait que doit être essentiellement rapide doux, mais, même moyens confortables, trains rapides, automobiles bien suspendues, n'y répondent très imparfaitement.
Abstract NMDA receptor ligands have been the target of intensive research for treatment psychotic diseases and central nervous system diseases. Our group published characterization histamine site. We developed modulators this site, about 500 drugs were tested we finally a partial agonist FUBn293 with nanomolar affinity also an antagonist ST-579 affinity. suggest that agonists at (NMDA (HA) R) constitute innovative class antipsychotics schizophrenia other neurological or psychiatric disorders.
Les dysplasies corticales focales de Taylor (DCF) presentent grands neurones aberrants dans une lamination corticale anormale. Le cortex dysplasique peut engendrer des decharges epileptiques qui utilisent les connexions conservees par ce tissu pour se propager. Nous avons etudie du cortical, ou non, obtenu lors la resection chirurgicale zone epileptogene chez patients souffrant d’une epilepsie rebelle aux traitements antiepileptiques. Dans tranches maintenues in vitro, nous analyse...
ABSTRACT Ultra-thin, transparent films are being used as protective layers on semiconductors, solar cells, well for nano-composite materials and optical coatings. Nano-sensors, photonic devices calibration tools axial super-resolution microscopies, all rely the controlled fabrication analysis of ultra-thin layers. Here, we describe a simple, non-invasive, technique simultaneously characterizing refractive index, thickness, homogeneity nanometric films. In our case, these made biomimetic...
Abstract The fabrication and characterisation of ultra-thin, transparent films is paramount for protective layers on semiconductors, solar cells, as well nano-composite materials optical coatings. Similarly, the probe volume nano-sensors, calibration axial distances in super-resolution microscopies, all require metrology fluorophore distances. However, reliable production precise such nanometric thin are difficult labor-intense they specialized equipment trained personnel. In our present...
This study attempted to clarify the role of histamine H1 receptors in epilepsy by exploring effects agonists and inverse on rundown current induced iterative applications NMDA or GABA. Mepyramine, a classical H1-receptor antagonist / agonist, increased about 40 % during first minutes recording. effect was concentration-dependent, maximal at 10 nM, mimicked triprolidine, another agonist. No endogenous being detected cultures selective immunoassay, both compounds were acting as agonists....