A5042031061- Burn Injury Management and Outcomes
- Wound Healing and Treatments
- Inhalation and Respiratory Drug Delivery
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Chemical Reactions and Isotopes
- Drug Transport and Resistance Mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Liver Disease Diagnosis and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- Chemical Synthesis and Analysis
- HIV/AIDS Research and Interventions
- Antibiotic Resistance in Bacteria
- HIV-related health complications and treatments
- Asthma and respiratory diseases
- Antimicrobial Resistance in Staphylococcus
- Protein Kinase Regulation and GTPase Signaling
- Pneumonia and Respiratory Infections
- HER2/EGFR in Cancer Research
- Tuberculosis Research and Epidemiology
University of North Carolina at Chapel Hill
2022-2025
Biocon (India)
2024
Bristol-Myers Squibb (India)
2024
ABSTRACT Foremost in the design of new β-lactamase inhibitors (BLIs) are boronic acid transition state (BATSIs). Two highly potent BATSIs being developed S02030 and MB076 strategically designed to be active against cephalosporinases carbapenemases, especially KPC. When combined with cefepime, demonstrated antimicrobial activity laboratory clinical strains Enterobacterales expressing a variety class A C β-lactamases, including bla KPC-2 KPC-3 . Static time-kill assays revealed bactericidal...
The pH-dependent solubility of the weakly basic TYK2 inhibitor 1 posed a risk to its advancement, given that drugs with such profiles have exhibited drug–drug interaction (DDI) stomach acid-reducing agents in humans. In rat model pH dependence, preadministration famotidine caused 2.4-fold lower exposure when compared control rats, implying oral absorption can reduce active drug's and translate subtherapeutic treatment. As part mitigation, prodrug strategy was explored by synthesizing...
Tuberculosis (TB), caused by
Long-acting injectable cabotegravir is more effective than daily oral PrEP at preventing HIV transmission due to improved adherence, but requires bi-monthly large-volume intramuscular injections. Subcutaneous (SC) contraceptive implants can be formulated with antiretrovirals for extended-duration PrEP. Islatravir (ISL) a first-in-class, investigational antiretroviral pharmacologic properties well-suited implant delivery. We performed preclinical studies the development of reservoir-style,...
Tuberculosis (TB), caused by Mycobacterium tuberculosis ( Mtb ), remains a leading cause of death with 1.6 million deaths worldwide reported in 2021. Oral pyrazinamide (PZA) is an integral part anti-TB regimens, but its prolonged use has the potential to drive development PZA resistant . converted active moiety pyrazinoic acid (POA) pyrazinamidase encoded pncA , and mutations are associated majority resistance. Conventional oral parenteral therapies may result subtherapeutic exposure lung,...
Burn induction methodologies are inconsistently described in rat models. A uniform burn wound model, which represents the clinical scenario, is necessary to perform reproducible research. The present protocol describes a simple and method create ~20% total body surface area (TBSA) full-thickness burns rats. Here, 22.89 cm2 (5.4 cm diameter) copper rod heated at 97 °C water bath was applied skin induce injury. with high thermal conductivity able dissipate heat deeper tissue burn. Histology...
Burn induction methodologies are inconsistently described in rat models. A uniform burn wound model, which represents the clinical scenario, is necessary to perform reproducible research. The present protocol describes a simple and method create ~20% total body surface area (TBSA) full-thickness burns rats. Here, 22.89 cm2 (5.4 cm diameter) copper rod heated at 97 °C water bath was applied skin induce injury. with high thermal conductivity able dissipate heat deeper tissue burn. Histology...