A5079027986- Cardiac, Anesthesia and Surgical Outcomes
- Airway Management and Intubation Techniques
- Tracheal and airway disorders
- Obstructive Sleep Apnea Research
- Anesthesia and Sedative Agents
- HIV Research and Treatment
- Organ Transplantation Techniques and Outcomes
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- HIV/AIDS drug development and treatment
- Trauma and Emergency Care Studies
- Liver Disease and Transplantation
- Hemodynamic Monitoring and Therapy
- Patient Safety and Medication Errors
- Diversity and Career in Medicine
- Traumatic Brain Injury and Neurovascular Disturbances
- Foreign Body Medical Cases
- Medical Education and Admissions
- Pharmacogenetics and Drug Metabolism
- Cardiac Ischemia and Reperfusion
- Global Health Workforce Issues
- Chemical Synthesis and Analysis
- Hospital Admissions and Outcomes
- Fungal Biology and Applications
- Plant Toxicity and Pharmacological Properties
- Clinical practice guidelines implementation
Bristol-Myers Squibb (India)
2016-2025
Syngene International (India)
2016-2025
Biocon (India)
2016-2025
The University of Texas Health Science Center at Houston
2011-2024
Institute of Medical Sciences
2017
Tufts Medical Center
2014
The University of Texas at Austin
2009
Glucagon-like peptide-1 receptor agonist (GLP-1 RA) use is rapidly increasing in the US, driven by its expanded approval for weight management addition to hyperglycemia patients with type 2 diabetes. The perioperative safety of these medications, particularly aspiration risk under anesthesia, uncertain.
Recent literature reports highlight the importance of renal outer medullary potassium (ROMK) channel in sodium and homeostasis emphasize potential impact that ROMK inhibitors could have as a novel mechanism diuretic heart failure patients. A series piperazine-based were designed optimized to achieve excellent potency, hERG selectivity, ADME properties, which led identification compound
Raloxifene (RX) in the presence of liver microsomes and glutathione (GSH) has shown oxidative bioactivation to reactive intermediates that are conjugated by GSH. L-Ergothioneine (ET) is a naturally occurring sulfhydryl amino acid, similar GSH, derived from dietary sources with antioxidant properties reported accumulate high concentrations animals humans. We hypothesized ET may have detoxification/conjugation Using rat human mouse, rat, dog, monkey, hepatocytes, novel ergothioneine conjugate...
Phosphate and amino acid prodrugs of the HIV-1 protease inhibitor (PI) atazanavir (1) were prepared evaluated to address solubility absorption limitations. While phosphate prodrug failed release 1 in rats, introduction a methylene spacer facilitated activation, but parent exposure was lower than that following direct administration 1. Val Val-Val dipeptides imparted low plasma parent, although high, reflecting good absorption. Screening additional acids resulted identification an l-Phe ester...
Liver transplant anesthesiology is an evolving and expanding subspecialty, programs have, in the past, exhibited significant variations of practice at centers across United States. In order to explore current patterns, Quality & Standards Committee from Society for Advancement Transplant Anesthesia (SATA) undertook a survey liver program directors.Program directors were invited participate online questionnaire. A total 110 identified 2018 Scientific Registry Recipients (SRTR) database....
The pH-dependent solubility of the weakly basic TYK2 inhibitor 1 posed a risk to its advancement, given that drugs with such profiles have exhibited drug–drug interaction (DDI) stomach acid-reducing agents in humans. In rat model pH dependence, preadministration famotidine caused 2.4-fold lower exposure when compared control rats, implying oral absorption can reduce active drug's and translate subtherapeutic treatment. As part mitigation, prodrug strategy was explored by synthesizing...
HIV-1 protease inhibitors (PIs), which include atazanavir (ATV, 1), remain important medicines to treat infection. However, they are characterized by poor oral bioavailability and a need for boosting with pharmacokinetic enhancer, results in additional drug-drug interactions that sometimes difficult manage. We investigated chemo-activated, acyl migration-based prodrug design approach improve the profile of 1 but failed obtain improved over dosing parent drug rats. This strategy was refined...
The role of uptake transporter (organic anion–transporting polypeptide [Oatp]) in the disposition a P-glycoprotein (P-gp) substrate (digoxin) at barriers central nervous system, namely, blood-brain barrier (BBB), blood-spinal cord (BSCB), and brain-cerebrospinal fluid (BCSFB), was studied using rat as preclinical species. In vivo chemical inhibition P-gp Oatp achieved elacridar rifampicin, respectively. Our findings show that (1) digoxin had low brain-to-plasma concentration ratio (B/P)...
Given potential disparity and limited allocation of deceased donor kidneys for transplantation, a new federal kidney system was implemented in 2014. Donor organ function estimated recipient survival this has implications perioperative management transplant recipients. Early analysis suggests that many the anticipated goals are being attained. For anesthesiologists, increased dialysis duration burdens end-stage renal disease include cardiopulmonary disease, challenging fluid, hemodynamic...
Cattano, D.*; Killoran, P. V.*; Iannucci, Maddukuri, Altamirano, A. Sridhar, S.*; Seitan, C.*; Chen, Z.†; Hagberg, C. A.* Author Information