A5076058449- Pharmaceutical studies and practices
- Pharmacogenetics and Drug Metabolism
- Pharmacological Effects and Toxicity Studies
- Body Composition Measurement Techniques
- Epilepsy research and treatment
- Drug Transport and Resistance Mechanisms
- Venous Thromboembolism Diagnosis and Management
- HIV/AIDS drug development and treatment
- Antibiotics Pharmacokinetics and Efficacy
- Hemodynamic Monitoring and Therapy
- Liver Disease Diagnosis and Treatment
- Advanced Drug Delivery Systems
- Dietary Effects on Health
- Statistical Methods in Clinical Trials
- Pediatric Pain Management Techniques
- Carbohydrate Chemistry and Synthesis
- Blood Coagulation and Thrombosis Mechanisms
- Phytochemicals and Medicinal Plants
- Atrial Fibrillation Management and Outcomes
- Metabolism and Genetic Disorders
- Electrolyte and hormonal disorders
- Regulation of Appetite and Obesity
- Cholinesterase and Neurodegenerative Diseases
- HIV Research and Treatment
- Ocular Surface and Contact Lens
University of North Carolina at Chapel Hill
2021-2024
University of Otago
2018-2020
Biocon (India)
2015-2019
Bristol-Myers Squibb (India)
2015-2019
Syngene International (India)
2015
While one in five children the USA are now obese, and more than three-quarters receive at least drug during childhood, there is limited dosing guidance for this vulnerable patient population. Physiologically based pharmacokinetic modeling can bridge gap understanding of how pharmacokinetics, including distribution clearance, changes with obesity by incorporating known obesity-related physiological children. The objective study was to develop a virtual population enable physiologically...
Dosing guidance for children with obesity is often unknown despite the fact that nearly 20% of US are classified as obese. Enoxaparin, a commonly prescribed low‐molecular‐weight heparin, dosed based on body weight irrespective status to achieve maximum concentration within narrow therapeutic or prophylactic target range. However, whether and without experience equivalent enoxaparin exposure remains unclear. To address this clinical question, 2,825 anti–activated factor X (anti‐Xa) surrogate...
Terminalia arjuna (Hindi name Arjuna, Family Combretacae) has been used in the treatment of cardiovascular disorders by Ayurvedic physicians. However, its properties have not scientifically evaluated so far. Therefore, present study was carried out to examine underlying mechanism effects aqueous solution extract. Intravenous (I. V.) administration extract found induce dose dependent decrease blood pressure (B. P.) and heart rate (H. R.). These extracts also inhibited carotid occlusion...
Phosphate and amino acid prodrugs of the HIV-1 protease inhibitor (PI) atazanavir (1) were prepared evaluated to address solubility absorption limitations. While phosphate prodrug failed release 1 in rats, introduction a methylene spacer facilitated activation, but parent exposure was lower than that following direct administration 1. Val Val-Val dipeptides imparted low plasma parent, although high, reflecting good absorption. Screening additional acids resulted identification an l-Phe ester...
In recent years prodrug strategy has been used extensively to improve the pharmacokinetic properties of compounds exhibiting poor bioavailability. Mechanistic understanding absorption and role intestine liver in activation oral prodrugs is crucial. Enalapril, a carboxyl ester prodrug, reported be metabolized by human carboxylesterase-1 (CES1) but not carboxylesterase-2 (CES2) its active metabolite enalaprilat. Further, it that small intestines both rat contain mainly CES2. The objective this...
Posaconazole (PSZ) is a triazole antifungal for the management of invasive fungal disease (IFD) in adults and children. Although PSZ available as an intravenous (IV) solution, oral suspension (OS) delayed-release tablets (DRTs), OS preferred formulation pediatric use because potential safety concerns associated with excipient IV difficulty swallowing intact by However, poor biopharmaceutical characteristics leads to unpredictable dose-exposure profile children, potentially risking...
Background: In vitro-in vivo extrapolation (IVIVE) of hepatic drug clearance ( CL ) involves the scaling intrinsic int,uH by functional liver size, which is approximated total volume LV as per convention. However, in most overweight and obese patients, includes abnormal fat, not thought to contribute elimination, thus overestimating . Therefore, lean LLV might be a more appropriate scaler Objective: The objective this work was assess application patients (BMI>25 kg/m2) using model...