A5053289413- Pharmacological Effects and Assays
- Adolescent and Pediatric Healthcare
- Metabolism and Genetic Disorders
- Neurotransmitter Receptor Influence on Behavior
- Pharmacological Effects and Toxicity Studies
- Neuroscience of respiration and sleep
- Epilepsy research and treatment
- Biochemical Analysis and Sensing Techniques
- Receptor Mechanisms and Signaling
- Health Literacy and Information Accessibility
- Mobile Health and mHealth Applications
- Neuroscience and Neuropharmacology Research
Rosalind Franklin University of Medicine and Science
2024
Central Michigan University
2016-2017
Our previous work has demonstrated that acute morphine administration causes powerful suppression of augmented breaths (ABs) at the low‐to‐mid dosage range for analgesia in adult rats. The present study was performed to determine extent which this ABs persists course prolonged administration. We studied breathing non‐invasively rats 2 separate experiments: Exp 1: animals were monitored immediately before, and repeatedly following s.c. bolus injections morphine, 4 mg/kg loading dose...
The prototypical μ‐opioid agonist, morphine, powerfully suppresses spontaneous augmented breaths (ABs). We previously found that this effect occurs at relatively low‐to‐moderate dosages, where traditional parameters of eupneic breathing (VT and f) are not overtly affected. Based upon the heterogeneity pharmacological properties among commonly prescribed opioid medications, we hypothesized suppression ABs would be significantly different in presence drugs other than morphine. To test this,...