A5033632798- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Metastasis and carcinoma case studies
- Genetic factors in colorectal cancer
- Vietnamese History and Culture Studies
- Privacy, Security, and Data Protection
- Cambodian History and Society
- Sexuality, Behavior, and Technology
- Salivary Gland Tumors Diagnosis and Treatment
- Bone and Dental Protein Studies
- Immune cells in cancer
- Cancer Cells and Metastasis
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Pediatric Hepatobiliary Diseases and Treatments
- MicroRNA in disease regulation
- Gastroesophageal reflux and treatments
- Oral and Maxillofacial Pathology
- Tumors and Oncological Cases
- Asian Culture and Media Studies
- Cancer-related molecular mechanisms research
- Pancreatitis Pathology and Treatment
Johns Hopkins University
2023-2025
Cancer Research Center
2023-2025
Johns Hopkins Medicine
2025
Tohoku University
2021-2024
University of Baltimore
2024
Tokyo Women's Medical University
2018-2024
Japan Pancreatic Disease Research Foundation
2024
Hosei University
2006
Abstract Pancreatic ductal adenocarcinoma (PDAC) poses a significant challenge due to late‐stage diagnoses. To improve patient outcomes, early intervention in precursor lesions such as intraductal papillary mucinous neoplasm (IPMN) is crucial. However, must be balanced against overtreatment of low‐risk that are unlikely progress, underscoring the need better understand molecular alterations neoplastic cells and changes tumor microenvironment (TME) drive progression IPMNs. In this study, we...
Long non-coding RNAs (lncRNAs) have emerged as a significant player in various cancers, including pancreatic cancer. However, how lncRNAs are aberrantly expressed cancers is largely unknown. We hypothesized that would be regulated by signaling pathways and contribute to malignant phenotypes of In this study, understand the significance mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK), which major aberrant pathway cancer, for expression lncRNAs, we performed...
Abstract Objectives Treating pancreatic ductal adenocarcinoma (PDAC) is a major clinical challenge, owing to its poor prognosis. Understanding the underlying molecular interactions may be crucial in determining PDAC intractability. We elucidated combinatory role of SMAD family member 4 (SMAD4) and Runt-related transcription factor 3 (RUNX3) PDAC. Methods Formalin-fixed paraffin-embedded tissues were obtained from 101 patients who underwent surgical resection SMAD4 RUNX3 expression was...
Salivary gland cancers (SGCs) are heterogeneous tumors, and precision oncology represents a promising therapeutic approach; however, its impact on SGCs remains obscure. This study aimed to establish translational model for testing molecular-targeted therapies by combining patient-derived organoids genomic analyses of SGCs. We enrolled 29 patients, including 24 with 5 benign tumors. Resected tumors were subjected organoid monolayer cultures, as well whole-exome sequencing. Organoid cultures...
Abstract In pancreatic ductal adenocarcinoma (PDAC), venous invasion (VI) is a necessary precursor to hematogenous dissemination, but little known about the molecular features of VI. To investigate these features, we performed spatial transcriptomic analysis foci VI, PDAC in stroma (PDAC-S), and normal duct surgically resected human tissue samples from eight treatment naïve patients. We GeoMx Digital Spatial Profiler 35 regions 39 PDAC-S, 14 duct. Through unbiased hierarchical clustering,...
Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer, with only 11% of patients surviving beyond 5 years. Intraductal papillary mucinous neoplasm (IPMN), precancerous lesion and the most common type neoplastic pancreatic cyst, presents critical opportunity for cancer interception, but drivers malignant progression in IPMN are still largely unknown. Although immunosuppressive microenvironment PDAC has been well characterized, timing development these immune...
This study aimed to clarify the molecular mechanism of remnant pancreatic cancer (PC) development after primary PC resection.
While the Internet and other on-line services have become powerful intellectual tools forums of personal group interaction, they also turned out to be providers pornography. Thus, protecting children from latter aspect has a great concern in many parts world In U.S., Senate recently passed Exon Bill. The Bill aims at ensuring that laws which already apply obscene, indecent, harassing use telephones mail should computer communications. On hand, Japan, similar problem regarding telephone been...
Abstract Background Pancreatic serous cystic neoplasm (SCN) is an uncommon exocrine neoplasm, which believed to be a benign entity. However, some of these neoplasms may occasionally attain metastatic ability. Von Hippel–Lindau disease (VHL) manifests dominantly inherited systemic syndrome accompanied by several or malignant tumors, including in various organs. We describe here long-term survival case who underwent surgical resection for metachronous liver metastases pancreatic SCN associated...
Loss of expression the gene ataxia-telangiectasia mutated (ATM), occurring in patients with multiple primary malignancies, including pancreatic cancer, is associated poor prognosis. In this study, we investigated detailed molecular mechanism through which ATM affects prognosis cancer.The levels and phosphorylated cancer who had undergone surgical resection were analyzed using immunohistochemistry staining. RNA sequencing was performed on ATM-knockdown pancreatic-cancer cells to elucidate...
Abstract: SMAD4/DPC4 is one of the “big four” genes, namely, KRAS, SMAD4, CDKN2A, and TP53, that are considered to play primary roles in tumorigenesis progression pancreatic cancer. Runt-related transcription factors (RUNX) important regulators lineage-specific gene expression developmental pathways. RUNX3 was initially found be a neurogenic TrkC neuron-specific factor also has critical functions lineage specification homeostasis CD8-lineage T lymphocytes. Besides, as tumor suppressor some...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)