A5092500168- Pregnancy and preeclampsia studies
- Electrolyte and hormonal disorders
- Pharmaceutical studies and practices
- MicroRNA in disease regulation
- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Cardiovascular Issues in Pregnancy
- Pharmacological Effects and Toxicity Studies
- Nitric Oxide and Endothelin Effects
- Birth, Development, and Health
Medical University of Graz
2023-2025
Endothelial dysfunction is associated with several lifestyle-related diseases, including cardiovascular and neurodegenerative it contributes significantly to the global health burden. Recent research indicates a link between risk factors (CVRFs), excessive production of reactive oxygen species (ROS), mitochondrial impairment, endothelial dysfunction. Circulating progenitor cells (EPCs) are recruited into vessel wall maintain appropriate function, repair, angiogenesis. After attachment, EPCs...
Abstract Recent research has highlighted the significance of succinate and its receptor in gestational diabetes (GDM) pathogenesis. However, a clear interconnection between placenta metabolism, levels, SUCNR1 signalling pregnancy pathologies remains elusive. Here, we set out to investigate potential role on labour placental mechanisms by combining clinical functional experimental data at same time as exploring specific SUCNR1‐mediated effects vascularization, addressing agonist actions....
Abstract High gestational weight gain (GWG) is a cardiovascular risk factor and may disturb neonatal endothelial function. Long non‐coding RNAs (lncRNAs) regulate gene expression epigenetically can modulate Endothelial colony forming cells (ECFCs), circulating precursors, are recruitable source of sustain function, vascular growth repair. We here investigated whether higher GWG affects ECFC function elucidated the role lncRNAs herein. Wound healing umbilical cord blood‐derived ECFCs after...
Background/Objectives: Inadequate cardiovascular adaptation during pregnancy impairs endothelial function and vascular resistance, contributing to complications such as pre-eclampsia (PE) gestational hypertension (GH). Neprilysin (NEP), a protease involved in regulation, has been linked PE, but its role remains unclear. This pilot study investigates the associations between soluble neprilysin (sNEP) markers of renal high-risk pregnancies without PE. Methods: Observed parameters were analyzed...
Abstract Disclosure: A. Kulovic-Sissawo: None. E. Weiss: Jantscher-Krenn: U. Hiden: Background: In the complex nature of pregnancy, female organism undergoes pivotal vascular and metabolic changes orchestrated by a tightly regulated interplay bioactive regulatory molecules. The neutral endopeptidase, neprilysin, exists both in membrane-bound soluble form (sNEP), with latter present circulatory system. Neprilysin degrades an exciting range peptides involved glycemic control (insulin B chain,...