A5108384066- High Altitude and Hypoxia
- Cystic Fibrosis Research Advances
- Inhalation and Respiratory Drug Delivery
- Neuroscience of respiration and sleep
- Travel-related health issues
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Acute Myeloid Leukemia Research
- Lung Cancer Diagnosis and Treatment
- Asthma and respiratory diseases
- Adipose Tissue and Metabolism
- Climate Change and Health Impacts
- Hematological disorders and diagnostics
- Neonatal Respiratory Health Research
- Acute Kidney Injury Research
- Pharmaceutical studies and practices
- Cardiac Imaging and Diagnostics
- Tracheal and airway disorders
- Platelet Disorders and Treatments
- Bone and Joint Diseases
- Family and Disability Support Research
- Hemoglobinopathies and Related Disorders
- Pediatric health and respiratory diseases
- Chronic Myeloid Leukemia Treatments
- Cardiac Arrest and Resuscitation
- Glioma Diagnosis and Treatment
München Klinik
2004-2024
Northwestern University
2023
University of Lausanne
2022
University Hospital Heidelberg
2021
Heidelberg University
2021
Universität Hamburg
2012-2019
Orthopädische Praxis
2014-2017
Noah's Ark Children's Hospital for Wales
2015
Ludwig-Maximilians-Universität München
1929-2013
LMU Klinikum
2011-2013
Background. Current research priorities in critical care medicine are focusing on long-term outcomes of survivors illness. Severe acute kidney injury (AKI) is a common occurrence intensive care. However, few studies have followed up these patients beyond 12 months after hospital discharge.
Acute kidney injury (AKI) requiring renal replacement therapy (RRT) is associated with high in-hospital morbidity and mortality in critically ill patients. Long-term outcomes have received little attention.The aim of this study was to characterize AKI-chronic disease (CKD) nexus patients AKI (RIFLE class F). We performed a single-centre prospective observational 425 consecutive RRT. None these had pre-existing disease. Primary were vital status function at hospital discharge 5 10 years...
A randomised, double-blind, placebo-controlled study was conducted to evaluate the effects of theophylline and acetazolamide in treatment sleep-disordered breathing (SDB) after fast ascent high altitude (3,454 m). The at a high-altitude research laboratory included 30 healthy male volunteers. Study medication either oral slow release (2×250 mg·day −1 ), ) or matched placebo tablet. Polysomnographic measurements were performed during two consecutive nights, acute mountain sickness, pulse...
Abstract Background Asthma is a heterogeneous chronic disease with different phenotypes and treatment responses. Thus, there high clinical need for molecular biomarkers to aid in differentiating these distinct phenotypes. As Micro RNA s (mi s), that regulate gene expression at the post‐transcriptional level, are altered experimental human asthma, circulating mi attractive candidates identification of novel biomarkers. This study aimed identify plasmatic ‐based through translational approach....
Hintergrund: Bei Patienten mit Cystischer Fibrose (CF) treten trotz Einführung der kausalen CFTR-Modulatortherapien pulmonale Exazerbationen (PEx) auf, die sich negativ auf Gesamtmorbidität auswirken. Zur Stabilisierung Lungenfunktion erfolgen intensive Inhalationstherapien, wobei mangelnde Adhärenz eine Hauptursache für Therapieversagen darstellt. In dieser Studie präsentieren wir Ergebnisse einer innovativen Versorgungsform, digitale Technologien Maßnahmen zur Verhaltensänderung...
In a randomized, double-blind cross-over study 10 subjects were exposed to simulated altitude of 4500 m for h after administration placebo, acetozolamide (250 mg bid) or theophylline bid). T2-weighted magnetic resonances images (MRI) and diffusion weighted MRI obtained directly exposure under hypoxic conditions. Although eight had moderate severe acute mountain sickness (AMS), we found no evidence cerebral oedema, irrespective the medication taken. Almost all showed decrease in inner...
Abstract Chronic lung disorders are usually associated with a hypoxia driven increase in red cell mass. However, patients cystic fibrosis (CF) often have normal or decreased haemoglobin levels. The present prospective observational study was performed to determine which factors were involved alterations the hematopoetic response corresponding arterial oxygen pressure. Sixty adult (age 21–51) stable CF included. They all had vitamin A, D, E, and K but no B12 supplementation. Twenty‐five on...
A randomized two-part study was conducted in order to determine the efficacy of theophylline treatment acute mountain sickness during fast ascent altitudes >2,500 m. Fourteen healthy male subjects participated a single-blind placebo-controlled crossover carried out decompression chamber (simulated altitude 4,500 m). second single-blind, at high-altitude research laboratory (3,454 m) and included 21 subjects. The medication either 375 mg oral slow-release (250 if <70 kg) or matched...
Besides the well-known eosinophilic granules, mature eosinophil granulocytes are containing a special form of smaller granules measuring about 100 (20–200) nm. The constant occurrence these specific microgranules (SM) eosinophils, as they named, is proved in eosinophils 20 different mammalian species out 7 orders including man. SM composed an opaque core bound with unit membrane. may be distinguished into 3 varieties, spheric (double spheric), dumbbell, and cup type. one or other type...
Berendsen, Remco R., Peter Bärtsch, Buddha Basnyat, Marc Moritz Berger, Hackett, Andrew M. Luks, Jean-Paul Richalet, Ken Zafren, Bengt Kayser, and the STAK Plenary Group. Strengthening altitude knowledge: a Delphi study to define minimum knowledge of illness for laypersons traveling high altitude. High Alt Med Biol. 23:330–337, 2022. Introduction: A lack among about hazards high-altitude exposure contributes morbidity mortality from acute mountain sickness (AMS), cerebral edema (HACE),...
A morphometric analysis of bone marrow trephine biopsies has been performed to study the frequency and planimetric characteristics so-called atypical micromegakaryocytes in chronic myeloid leukemia (CML) myelodysplastic syndromes (MDS). In addition, an attempt was made discriminate this particular cell population from small immature elements megakaryocytopoiesis, such as promegakaryoblasts megakaryoblasts. The staining reactions employed included periodic acid-Schiff (PAS), alpha-naphthyl...
Ziel der Studie: Um die Möglichkeit einer 80 - 90 %igen Dosisreduktion bei Thorax-CT-Kontrollen chronischer Lungenerkrankungen zu prüfen, wurde ein Niedrigdosisprotokoll (ND-CT) hinsichtlich Bildqualität untersucht. Patienten und Methode: Bei 35 mit nichtmalignen zur Kontrolle eine ND-CT (120 kV, 10 mAs/Schicht, 3 mm Schichtdicke) durchgeführt initialen Standard-Dosis-CT (= SD-CT, 120 100 oder 5 verglichen. Die Dosis Thermolumineszenz-Dosimetrie am Alderson-Phantom gemessen. von vier...