A5103193127- Yersinia bacterium, plague, ectoparasites research
- Bacteriophages and microbial interactions
- Antibiotic Resistance in Bacteria
- Bacillus and Francisella bacterial research
- Cancer Research and Treatments
- Burkholderia infections and melioidosis
- Zoonotic diseases and public health
- Vector-borne infectious diseases
- Plant Gene Expression Analysis
- Pharmaceutical and Antibiotic Environmental Impacts
- Mitochondrial Function and Pathology
- Ethnobotanical and Medicinal Plants Studies
- Border Security and International Relations
- Fish Biology and Ecology Studies
- Epigenetics and DNA Methylation
- Studies on Chitinases and Chitosanases
- Retinal and Macular Surgery
- Ferroptosis and cancer prognosis
- Ubiquitin and proteasome pathways
- Enterobacteriaceae and Cronobacter Research
- Plant Stress Responses and Tolerance
- Bioenergy crop production and management
- Gut microbiota and health
- Rabies epidemiology and control
- Poxvirus research and outbreaks
National Institute for Communicable Disease Control and Prevention
2014-2025
Wuhan University
2023-2024
Zhejiang University
2024
Ningbo Transportation Planning and Design Institute (China)
2024
Central Hospital of Zibo
2024
Shanghai Zhangjiang Laboratory
2023
Institute of Physics
2023
State Key Laboratory of Infectious Disease Prevention and Control
2018-2021
Chinese Center For Disease Control and Prevention
2018-2021
South China University of Technology
2021
Abstract Background Sorghum ( bicolor ) is globally produced as a source of food, feed, fiber and fuel. Grain sweet sorghums differ in number important traits, including stem sugar juice accumulation, plant height well grain biomass production. The first whole genome sequence sorghum available, but additional sequences are required to study genome-wide intraspecific variation for dissecting the genetic basis these traits tailor-designed breeding this C 4 crop. Results We resequenced two one...
Streptomycin is considered to be one of the effective antibiotics for treatment plague. In order investigate streptomycin resistance Y . pestis in China, we evaluated susceptibility 536 strains China vitro using minimal inhibitory concentration (MIC) and screened resistance-associated genes ( strA strB ) by PCR method. A clinical isolate (S19960127) exhibited high-level (the MIC was 4,096 mg/L). The strain (biovar antiqua) isolated from a pneumonic plague outbreak 1996 Tibet Autonomous...
The rapid dissemination of colistin resistance via mcr-carrying plasmids (pMCRs) poses a significant public health challenge. This study examined the genomic diversity and conjugation mechanisms pMCRs, with particular focus on role type IV secretion systems (T4SS) in IncI2 plasmids. 868 complete plasmid sequences revealed various replicon types as primary epidemic type, co-transfer risk multidrug genes associated IncHI2. T4SS was identified 89.9% sequence exclusively carried by being...
Summary Rice blast, caused by Magnaporthe oryzae , significantly impacts grain yield, necessitating the identification of broad‐spectrum resistance genes and their functional mechanisms for disease‐resistant crop breeding. Here, we report that rice with knockdown OsHDAC1 gene expression displays enhanced blast without effects on plant height tiller numbers compared to wild‐type rice, while overexpressing is more susceptible M. . We identify a novel transcription factor, OsGRAS30, which...
Melioidosis is a severe infectious disease caused by gram-negative, facultative intracellular pathogen Burkholderia pseudomallei (B. pseudomallei). Although cases are increasing reported from other parts of the world, it an illness tropical and subtropical climates primarily found in southeast Asia northern Australia. Because 40% mortality rate, this life-threatening poses public health risk endemic area. Early detection B. infection vital for prognosis melioidosis patient. In study, novel...
Abstract We analyzed 10 isolates of Francisella tularensis subspecies holarctica from China and assigned them to known clades by using canonical single-nucleotide polymorphisms. found 4 diverse subtypes, including 3 the most basal lineage, biovar japonica. This result indicates unprecedented levels diversity a single region suggests new models for emergence.
The Qinghai-Tibet plateau is a natural plague focus and the largest such in China. In this area, while Marmota himalayana primary host, total of 18 human outbreaks associated with Tibetan sheep (78 cases 47 deaths) have been reported on since 1956. All index infectious had an exposure history slaughtering or skinning diseased dead sheep. study, we sequenced compared 38 strains Yersinia pestis isolated from different hosts, including humans, sheep, M. himalayana. Phylogenetic relationships...
On 12 November 2019, one couple from the Sonid Left Qi (County) in Inner Mongolia Autonomous Region was diagnosed with pneumonic plague Beijing. The wife acquired infection her husband. Thereafter, two bubonic cases were identified on 16 th and 24 . In this study, genome-wide single nucleotide polymorphism (SNP) analysis used to identify phylogenetic relationship of Yersinia pestis strains isolated Mongolia. Strains reservoirs 2018 2019 Mongolia, together strain Patient C, further clustered...
Francisella tularensis causes a highly infectious zoonotic disease tularemia. Both Haemaphysalis longicornis and Hyalomma asiaticum are widely distributed in China, but the presence of Francisella-like endosymbionts (FLEs) two tick species is poorly understood. Therefore, total 627 H. (471 adults 156 nymphs) 88 Hy. ticks (adults) were collected, which from Bole Xinjiang, 236 Liaoyang, 176 Shenyang Liaoning, 215 Wuhan Hubei. Notably, five pools Liaoyang Liaoning province might have harbored...
Abstract This paper mainly introduces the emergency repair process for small- and medium-span bridges. The causes of deterioration were analysed by investigating old After comparison selection schemes, scheme beam replacement was confirmed using a lightweight steel ultra-high performance concrete (UHPC) composite as superstructure. main components calculations design are introduced in detail. Finally, through load test bridge, it shown that steel-UHPC had good met requirements Highway Level...
The surveillance of antimicrobial resistance genes (ARGs) and bacteria is one critical approach to prevent control (AMR). Next-generation sequencing (NGS) a powerful tool in monitoring the emergence spread ARGs resistant bacteria. horizontal transfer across host mediated by plasmids challenge NGS for because short-read can hardly generate complete plasmid genome sequence, correlation between are difficult determine.The sequences 455 mcr-carrying (pMCRs), data their isolation regions were...
Antibiotic-resistant bacteria (ARB) and antibiotic-resistance genes (ARGs) have been detected in human-impacted habitats, especially densely populated cities. The Qinghai-Tibet Plateau is located far from the heavily regions of China, Tibetan residents distinct dietary habits gut microbes. Antibiotic-resistance monitoring population rare. Here, we collected stool samples outpatients with diarrhea. From 59 samples, 48 antibiotic-resistant Enterobacteriaceae isolates were obtained, including...
Conserved serine phosphorylation regulates histone deacetylase activity in Arabidopsis and humans
Abstract Melioidosis is a severe infectious disease caused by gram-negative, facultative intracellular pathogen Burkholderia pseudomallei ( B. ). Although cases are increasing reported from other parts of the world, it an illness tropical and subtropical climates primarily found in southeast Asia northern Australia. Because 40% mortality rate, this life-threatening poses public health risk endemic area. Early detection infection benefits greatly to implement effective treatment timely, which...
Fungal chitinases play essential roles in chitin degradation, cell wall remodeling, recycling, nutrition acquisition, autolysis, and virulence. In this study, 18 genes of the glycoside hydrolase (GH18) family were identified Isaria cicadae genome. Seventeen belonged to one was an endo-β-N-acetylglucosaminidase (ENGase). According phylogenetic analysis, 17 designated as subgroups A (7 chitinases), B (7), C (3). The exon-intron organizations these analyzed. conserved regions DxxDxDxE S/AxGG...
Prostate cancer (PCa) is a common malignancy among men worldwide. Iron oxide (Fe 3 O 4 ) nanoparticles (NPs) exhibit great potential in gene delivery and studies have noted the inhibitory effect of miR-124 on PCa cell growth. Herein, we identified therapeutic Fe NPs carrying clarified its mechanism action inhibiting progression PCa. After preparation miR-124, human line PC3 was treated with miR-124-Fe when ferroptosis inducer FIN56, inhibitor Liproxstatin-1, Phosphatase tensin homolog (PTEN)...
The purpose of the present study was to assess clinical characteristics X‑linked retinoschisis (XLRS) in a Chinese family over 7‑year period with aim identifying possible genetic mutations associated this disease. A total 2 male siblings from XLRS were followed up for 7 years and best‑corrected visual acuity data obtained using slit‑lamp microscopy, indirect ophthalmoscopy, fundus photography, spectral domain‑optical coherence tomography (OCT), autofluorescence fluorescence (FFA) multifocal...