A5103144224- Pharmacological Effects and Toxicity Studies
- Epilepsy research and treatment
- Electrochemical sensors and biosensors
- Neuroscience and Neuropharmacology Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Metabolism and Genetic Disorders
- Nitric Oxide and Endothelin Effects
- Venous Thromboembolism Diagnosis and Management
- Pharmaceutical studies and practices
- Total Knee Arthroplasty Outcomes
- Atrial Fibrillation Management and Outcomes
- Congenital Anomalies and Fetal Surgery
- Meat and Animal Product Quality
- Enzyme function and inhibition
- Allergic Rhinitis and Sensitization
- Knee injuries and reconstruction techniques
- Olfactory and Sensory Function Studies
- Muscle metabolism and nutrition
- Lipid metabolism and biosynthesis
- Diagnosis and Treatment of Venous Diseases
- Nasal Surgery and Airway Studies
- Biochemical Acid Research Studies
- Sarcoma Diagnosis and Treatment
- Intestinal Malrotation and Obstruction Disorders
- Coenzyme Q10 studies and effects
Frederiksberg Hospital
2016
Hvidovre Hospital
1989-2009
Novartis (Switzerland)
1990-2009
Plough Foundation
2008
Rigshospitalet
1965-2006
Copenhagen University Hospital
2006
Odense University Hospital
2006
University of Copenhagen
1961-1996
CNS Research (United States)
1996
Wallace Laboratories
1996
Aim: A previous phase 2 study of patients undergoing non-urgent PCI treated with SCH530348 plus aspirin and clopidogrel tended to reduce MACE without increased bleeding. This evaluated the safety in Japanese NSTE ACS.Methods: Subjects (117), whom was planned, received standard-of-care (aspirin, ticlopidine, heparin) were randomized 4:1 receive either (20 or 40 mg loading dose followed by 1 mg/d 2.5 for 60 days) placebo. The key endpoint TIMI major minor bleeding cohort (n=92). exploratory...
The effects of felbamate on the pharmacokinetics a low-dose combination oral contraceptive containing 30 μg ethinyl estradiol and 75 gestodene were assessed in randomized, double-blind, placebo-controlled parallel-group study healthy premenopausal female volunteers established regimen use. They received either placebo or 2400 mg/day from midcycle (day 15) to 14) two consecutive cycles (months 1 2). Pharmacokinetic assessments performed day 14 both cycles. To determine whether ovulation...
To estimate the risk and evaluate long-term outcome of knee ankle injuries in former national team elite football, 69 players were randomly selected, followed by clinical stress radiographic examinations. Thirty-nine (49 knees) had 29 (35 ankles). The median time from injury until study examination was 25 years. tears medial collateral ligament (MCL) 24 cases combined with rupture anterior cruciate (ACL) meniscus lesions three. Meniscus occurred 17 including three ACL MCL another two...
Summary: Felbamate (FBM, Felbatol/Taloxa), a new an‐tiepileptic drug (AED), was tested in placebo‐controlled add‐on design 73 patients with therapy refractory Lennox‐Gastaut syndrome. Results of the efficacy analysis showed that FBM statistically significantly more effective (p < 0.05) than placebo for four five predefined variables. The total number seizures, example, decreased by 26% during treatment compared an increase 5% 0.001). Retrospective percentage specific response rates...
When erythromycin (ERY) is co-administrated with the antiepileptic carbamazepine (CBZ), a drug interaction may cause an increase in CBZ plasma concentrations, which can result related toxic symptoms. This cross-over study was designated to investigate whether ERY influences pharmacokinetics of new oxcarbazepine (OXC) and its metabolites. In 8 healthy volunteers there were no significant differences AUC, peak concentrations or time concentration when OXC administered either without ERY. The...
The effects of dextropropoxyphene on the steady-state kinetics oxcarbazepine and its metabolites were investigated in eight patients with epilepsy or trigeminal neuralgia. One patient dropped out study, presumably due to side-effects dextropropoxyphene. Dextropropoxyphene did not affect plasma levels principal active metabolite, 10,11-dihydro-10-hydroxy-carbamazepine. Since is known increase carbamazepine, leading toxicity, findings this study suggest that a useful alternative carbamazepine...
We reviewed the medical records of 750 patients (445 men, 305 women), who had received a kidney transplant during period 1968-1995, for any sign necrosis femoral head. For post-operative immunosuppression, 374 high-dose corticosteroids (average 12.5 g first year post-operatively), while 376 low-dose 6.5 post-operatively) and cyclosporin A. Survival curves according to Kaplan Meier (J Am Stat Ass 1958: 53: 457-481) were constructed. In steroid group, 42/374 (11.2%) developed head necrosis, at...
In a single-blind pharmacokinetic study patients being treated with conventional carbamazepine (CBZ) in t.i.d. regimen were randomly allocated to identical doses of two CBZ slow-release formulations (Trimonil Retard® and Tegretol Retard®) administered once daily. Statistical analysis involved the following parameters: AUC, Cmin, Cmax Fluctuation Index (FI). With regard Cmin FI statistically significant differences favour observed.
Summary The effects of age on felbamate apparent clearance were examined through a retrospective analysis plasma concentration data from 700 pediatric and adult epileptic patients (age range, 2-74 years) enrolled in six clinical studies. Patients received as monotherapy or combination with either the antiepileptic drugs (AEDs) carbamazepine (CBZ), phenytoin (PHT), valproate (VPA). Data analyzed using nonlinear mixed-effects pharmacostatistical modeling technique (NONMEM). Factors model...
Summary: Felbamate (FBM) is a new antiepileptic drug (AED) that has been tested in open and controlled studies patients with therapy‐refractory partial‐onset seizures. Proof of efficacy based on results five (three polytherapy two monotherapy). In the three studies, classic placebo crossover design was used. The third study used novel evaluating FBM placebo‐controlled parallel completing an evaluation for epilepsy surgery. primary variable this number who experienced fourth seizure before...
Background The occurrence of club foot (CF) varies between countries and populations, may be related to endogenous exogenous factors. We analyzed the CF in a whole country over long period time (16 years).Methods Patients born Denmark with deformity 1978–93 were identified from National Patient Register Inborn Malformations. records for each patient studied hospital departments establish diagnoses obtain additional information. Demographic data obtained Danish Demographical Institute...