A5012761965- Oral microbiology and periodontitis research
- Salivary Gland Disorders and Functions
- Oral Health Pathology and Treatment
- Mesenchymal stem cell research
- Oral and gingival health research
- Endodontics and Root Canal Treatments
- Periodontal Regeneration and Treatments
- Fibroblast Growth Factor Research
- Peroxisome Proliferator-Activated Receptors
- Metabolism, Diabetes, and Cancer
- Dental Implant Techniques and Outcomes
- Diabetes and associated disorders
- Esophageal and GI Pathology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Proteoglycans and glycosaminoglycans research
- Bone Tissue Engineering Materials
- Laser Applications in Dentistry and Medicine
Tokyo Medical and Dental University
2021-2024
The University of Tokyo
2021-2024
Abstract Aim This study aimed to investigate the effects of diabetes care on periodontal inflammation. Materials and Methods prospective cohort included 51 Japanese patients with type 2 who underwent intensive including educational hospitalization regular outpatient treatment for 6 months. Dental prophylaxis without subgingival scaling was provided three times during observational period. Associations between changes in parameters glycaemic control levels were evaluated using multiple...
Few studies have reported on the impact of oxidative stress dental implant failure. The aim this study was to investigate hyperglycemia-induced osseointegration in diabetes mellitus (DM).Acid-treated titanium implants were bilaterally placed maxillary alveolar ridge streptozotocin-induced diabetic (DM group) and control rats after extraction first molars. Histological analysis micro-push-out test performed 4 weeks surgery. Oxidative osteogenic markers surrounding bone quantified by real-time...
Introduction The aim was to investigate the relationship of full-mouth inflammatory parameters periodontal disease with diabetes and obesity. Research design methods This cross-sectional study conducted diabetes-related examinations calculated inflamed epithelial surface area (PISA PESA) 71 Japanese patients type 2 diabetes. Multiple linear regression analyses were performed evaluate associations between PISA or PESA obesity parameters. Results Median value body mass index (BMI), hemoglobin...
This study aimed to investigate the effects of metformin on gingival wound healing in insulin-resistant prediabetes.C57BL/6J mice were fed normal diet (ND) or high-fat (HFD) for 10 weeks; half HFD treated with (HFD+ Met) last 2 weeks. Insulin and glucose tolerance tests performed. The palatal gingiva (2.0 × 0.5 mm) was surgically removed adjacent maxillary molars. Post-surgical closure histomorphometrically evaluated 1 week. mRNA expression vascular endothelial growth factor (VEGF) nitric...
Diabetes involves metabolic disorders in various tissues via hyperglycemia-induced oxidative stress. This study aimed to investigate the antioxidative effect of enamel matrix derivative (EMD) on periodontal regeneration diabetes.Twenty-two rats were equally divided into streptozotocin (STZ)-induced diabetes or control group. Two months after induction hyperglycemia, systemic stress was measured using urinary 8-hydroxy-2'-deoxyguanosine. EMD saline applied intrabony defects created bilateral...
Abstract Background This study aimed to investigate the effects of low‐level erbium‐doped: yttrium, aluminum, and garnet (Er:YAG) laser irradiation on periodontal tissue healing regeneration through angiogenesis in vivo vitro studies. Methods Intrabony defects were surgically created bilateral maxilla molar rats. The treated by open flap debridement (OFD) with Er:YAG laser, including (LLLI) bone blood clot surfaces, or conventional procedures. mRNA expression vascular endothelial growth...
This study aims to investigate the mechanisms underlying impaired healing response by diabetes after periodontal therapy.
Abstract Background This study aims to investigate the mechanisms underlying exacerbated healing response by diabetes after periodontal therapy. Methods Zucker diabetic fatty (ZDF) and lean (ZL) rats underwent experimental periodontitis ligating mandibular molars for one week. The gingiva at ligated sites was harvested day ligature removal, gene expression comprehensively analyzed using RNA-Seq. In patients with without type-2 (T2D), corresponding quantified in of shallow sulcus residual...