A5087777471- PI3K/AKT/mTOR signaling in cancer
- Cancer Immunotherapy and Biomarkers
- Mast cells and histamine
- Helicobacter pylori-related gastroenterology studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- HIV/AIDS oral health manifestations
- Hepatitis C virus research
- Immunotherapy and Immune Responses
- Lung Cancer Treatments and Mutations
- Influenza Virus Research Studies
- Liver Disease Diagnosis and Treatment
- Heart Rate Variability and Autonomic Control
- Health and Medical Research Impacts
- Autoimmune Bullous Skin Diseases
- Synthesis and Biological Evaluation
- Clostridium difficile and Clostridium perfringens research
- Eosinophilic Esophagitis
- Brain Metastases and Treatment
- Galectins and Cancer Biology
- Oral Health Pathology and Treatment
- Biomedical Ethics and Regulation
- Veterinary medicine and infectious diseases
- Diabetes Management and Research
- Microscopic Colitis
- Virology and Viral Diseases
Universidad de Navarra
2022-2025
Centro de Investigación Biomédica en Red de Cáncer
2024-2025
University of Calgary
2025
Instituto de Salud Carlos III
2024
Clinica Universidad de Navarra
2023
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
1999-2013
Clínica Ruiz
1999
Hôpital Rothschild
1998
Sorbonne Université
1998
Hospital Clínico de la Universidad de Chile
1996
Immunotherapy resistance in non-small cell lung cancer (NSCLC) may be mediated by an immunosuppressive microenvironment, which can shaped the mutational landscape of tumor. Here, we observed genetic alterations PTEN/PI3K/AKT/mTOR pathway and/or loss PTEN expression >25% patients with NSCLC, higher frequency squamous carcinomas (LUSC). Patients PTEN-low tumors had levels PD-L1 and PD-L2 showed worse progression-free survival when treated immunotherapy. Development a Pten-null LUSC mouse model...
Background In the tumor microenvironment (TME), tumor-associated macrophages (TAMs) play a key immunosuppressive role that limits ability of immune system to fight cancer. Toll-like receptors (TLRs) ligands, such as poly(I:C) or resiquimod (R848) are able reprogram TAMs towards M1-like antitumor effector cells. The objective our work has been develop and evaluate polymeric nanocapsules (NCs) loaded with poly(I:C)+R848, improve drug stability systemic toxicity, their targeting therapeutic...
ABSTRACT Helicobacter pylori virulence determinants have not previously been studied in detail Latin Americans with H. infections. We characterized the vacA (vacuolating cytotoxin gene A) and cagA (cytotoxin-associated types of more than 400 single-colony isolates from 20 patients Mexico City. For 17 strains two or different genotypes were isolated gastric biopsy specimens, indicating infection . The most frequent genotype was s1b/m1. diversity marked that described previously, seven had...
Enterococci are part of the normal intestinal flora in a large number mammals, and these microbes currently used as indicators fecal contamination water food for human consumption. These organisms considered one primary causes nosocomial environmental infections due to their ability survive environment intrinsic resistance antimicrobials. The aims this study were determine biochemical patterns antimicrobial susceptibilities Enterococcus faecalis E. faecium isolates from clinical samples...
ABSTRACT Background Co‐build is one of the four pillars Patient Engagement Framework from Canadian Institutes Health Research Strategy for Oriented Research. Collaborating with Partners (PRPs) using co‐build approaches can enhance applicability healthcare tools produced. Human Centred Design (HCD), a problem‐solving methodology focused on creating functional solutions users, offers promising approach to co‐building patient engagement tools. Objective To describe process HCD PRPs and identify...
Gastric cancer is the most frequent tumor of digestive tract in Mexico. Most patients are diagnosed at advanced stages, and fatal outcome expected. One hundred fifty patient charts were retrospectively reviewed. Univariate multivariate analyses performed to evaluate impact clinicopathologic treatment variables on survival. (75%) harboring poorly differentiated tumors. Surgery, mostly palliative, was 114 patients. Chemotherapy administered 47 On univariate analysis, significant prognostic...
One hundred and twenty‐five HIV‐infected patients, of whom 49 (39%) were at early stages the infection (CDC‐II & III) 76 (61%) in CDC IV, prospectively examined. In 100 (80%) one or more oral mucosal lesions observed; candidiasis (51%) hairy leukoplakia (43%) commonest. Erythematous was often seen (35%) than pseudomembranous type (16%), appeared with higher values later stages. The prevalence leukoplakia, hyperpigmentation xerostomia incremented groups CDC‐IV. Pseudomembranous...
To know the incidence, etiology, risk factors, morbidity, and mortality of nosocomial diarrhea in adults.Nested case-control study, matched by service, length stay, date admission, presence leukopenia and/or acquired immunodeficiency syndrome (AIDS). Cases were those who developed diarrhea. Controls did not develop during a comparative period nor next ten days. Stool samples processed search for parasites, yeasts, bacteria, rotavirus.Third-level referral center, Mexico City, Mexico, general...
Hepatocellular carcinoma (HCC) is a malignant neoplasm associated with liver cirrhosis, an annual incidence of 3% to 9%, which one the main causes death in patients cirrhosis. Viral hepatitis increased risk HCC, probably due inflammatory reaction. Colchicine antiinflammatory agent that inhibits formation intracellular microtubules, affecting mitosis and fibrogenesis. Diverse clinical studies have failed demonstrate benefit colchicine over progression fibrosis cirrhosis; nevertheless,...
A follow-up study was carried out to evaluate the prognostic value of hairy leukoplakia (HL) and oral candidosis (OC) in a cohort 111 asymptomatic Mexican HIV infected patients. Oral exams were performed at baseline every 6 months, from September 1989 March 1994. Chi-square contingency table test, Kruskall-Wallis one-way analysis variance, Kaplan-Meier product-limit method log rank test used for analysis. Univariate multivariate Cox's proportional hazards also performed. Fifty-four patients...
Background Virulence factors of Helicobacter pylori are associated with peptic ulcer disease and may be also bleeding ulcers (BPU). Aim To determine whether H. and/or the cytotoxin-associated gene (cagA) can increase risk in ulcers. Patients Sixty-seven patients were studied. Thirty had BPU, 20 non-bleeding (NBPU), 17 control subjects (NPU). Methods The prevalence was assessed by urease fast test, histological examination, serology, 16S ribosomal RNA cagA amplification polymerase chain...
Abstract The treatment of non-small cell lung cancer (NSCLC) patients has significantly improved with recent therapeutic strategies; however, many still do not benefit from them. As a result, new approaches are urgently needed. In this study, we evaluated the antitumor efficacy co-targeting G9a and DNMT1 enzymes its potential as drug sensitizer. We observed co-expression overexpression in NSCLC, which were associated poor prognosis. Co-targeting G9a/DNMT1 CM-272 reduced proliferation induced...
Abstract Immune checkpoint inhibitors (ICIs) targeting PD-L1/PD-1 have dramatically improved the management of NSCLC patients. Nevertheless, more than 50% patients will present primary resistance or develop secondary within 12-25 months after treatment initiation. The mechanisms to ICIs may depend on tumor-intrinsic molecular/genetic alterations that generate an immunosuppressive tumor microenvironment (isTME). Using In silico analyses (TCGA and AACR-GENIE cohorts), protein expression...
Brain radiation necrosis (RN) is a subacute or late adverse event following radiotherapy, involving an exacerbated inflammatory response of the brain tissue. The risk symptomatic RN associated with stereotactic radiosurgery (SRS) as part treatment metastases (BMs) has been subject recent investigation. activation signal transducer and activator transcription 3 (STAT3) was shown in reactive astrocytes (RA) BMs. Given that pathophysiological mechanisms behind are not fully understood, we...