A5033267368- PI3K/AKT/mTOR signaling in cancer
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Mast cells and histamine
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- DNA Repair Mechanisms
- Lung Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Cancer Diagnosis and Treatment
- Renal and related cancers
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Urinary and Genital Oncology Studies
- RNA modifications and cancer
- BRCA gene mutations in cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neurofibromatosis and Schwannoma Cases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Liver physiology and pathology
Clinica Universidad de Navarra
2021-2024
Hospital Universitario Virgen del Rocío
2021
Anthrologica
2021
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2012-2020
Universidad Complutense de Madrid
2012-2020
Hospital Clínico San Carlos
2007-2019
Centro de Investigación Biomédica en Red de Cáncer
2017
University of Illinois Chicago
2011
Hospital Materno-Infantil
2000
Universidad de Navarra
1993-1996
Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a hereditary syndrome in which affected individuals are predisposed to the development of multiple leiomyomas skin uterus aggressive forms kidney cancer. Affected harbor germline heterozygous loss-of-function mutation fumarate hydratase (FH) gene. Uterine present up 77% women with this syndrome. Previous studies have shown that inactivation FH gene unusual for nonsyndromic leiomyomas. Therefore, it might be possible distinguish 2...
Abstract Background Colon cancer patients with the same stage show diverse clinical behavior dueto tumor heterogeneity. We aimed to discover distinct classes of tumorsbased on microarray expression patterns, analyze whether molecularclassification correlated histopathological stages or otherclinical parameters and study differences in survival. Methods Hierarchical clustering was performed for class discovery 88 colon tumors(stages I IV). Pathways analysis correlations between...
Abstract In 2011 the Spanish Society of Medical Oncology (SEOM) and Pathology (SEAP) started a joint project to establish guidelines on biomarker testing in patients with advanced non-small-cell lung cancer (NSCLC) based current evidence. As this field is constantly evolving, these have been updated, previously 2012 2015 now 2019. Current evidence suggests that mandatory tests conduct all NSCLC are for EGFR BRAF mutations, ALK ROS1 rearrangements PD-L1 expression. The growing need study...
Immunotherapy resistance in non-small cell lung cancer (NSCLC) may be mediated by an immunosuppressive microenvironment, which can shaped the mutational landscape of tumor. Here, we observed genetic alterations PTEN/PI3K/AKT/mTOR pathway and/or loss PTEN expression >25% patients with NSCLC, higher frequency squamous carcinomas (LUSC). Patients PTEN-low tumors had levels PD-L1 and PD-L2 showed worse progression-free survival when treated immunotherapy. Development a Pten-null LUSC mouse model...
In 1983, Pretlow et al. reported one classical study of the prognostic influence eosinophil infiltration in human colon carcinoma. Since then, very few reports have analyzed this supposed type tumor, although there been several other types tumors with different results. Eosinophils seem to play a central role immunologic defense against tumors; their activity can be induced through immunotherapy interleukin cases that are unresponsive conventional therapies.To analyze eosinophils colorectal...
Accurate measurement of tumor burden in breast cancer disease is essential to improve the clinical management patients. In this study, we evaluate whether fluctuations fraction PIK3CA mutant allele correlates with response according RECIST criteria and markers quantification. Eighty six plasma samples were analyzed by digital PCR using Rare Mutation Assays for E542K, E545K H1047R. Mutant cfDNA CA15-3 CEA compared radiographic imaging. The agreement between mutation status FFPE circulating...
IntroductionThe ROS1 gene rearrangement has become an important biomarker in NSCLC. The College of American Pathologists/International Association for the Study Lung Cancer/Association Molecular Pathology testing guidelines support use immunohistochemistry (IHC) as a screening test, followed by confirmation with fluorescence situ hybridization (FISH) or molecular test all positive results. We have evaluated novel anti-ROS1 IHC antibody (SP384) large multicenter series to obtain real-world...
Background Based on the excellent results of clinical trials with ALK-inhibitors, importance accurately identifying ALK positive lung cancer has never been greater. However, there are increasing number recent publications addressing discordances between FISH and IHC. The controversy is further fuelled by different regulatory approvals. This situation prompted us to investigate two IHC antibodies (using a novel ultrasensitive detection-amplification kit) an automated scanning system...
Gastric cancer (GC) continues to be a highly aggressive malignancy with poor prognosis and low survival rates. The of patients GC depends mainly on the stage disease, early having 5 year 90-100% advanced tumors 15-25%. role other prognostic factors in these is still under investigation. 28 gastric dysplasia, 45 Early 98 Advanced Cancers were evaluated for expression oncogenes p53, c-ErbB2, c-myc EGFr paraffin-embedded material utilizing Avidin-Biotin immunohistochemistry techniques. In 34...
The WHO grading scheme distinguishes benign (grade I), atypical II) and anaplastic III) meningiomas. Both meningiomas exhibited an overall increased rate of recurrence, but between 15-20% will also exhibit unfavourable clinical course with recurrence before 10 years despite aggressive surgery. We investigated 247 cases grade I II. immunohistochemical expression 30 different molecular biomarkers cell adhesion molecules, cell-cycle apoptosis regulators checkpoints was analyzed. determined by...
Familial colorectal cancer type X (FCCX) encompasses a group of families with dominant inheritance pattern (CRC) but no alteration in any known CRC susceptibility gene. Therefore, the explanation their is priority to offer an accurate genetic counseling. We screened 27 coding exons and exon-intron boundaries BRCA2 48 FCCX probands. identified 29 variants including frameshift mutation. Deleterious variant c.3847_3848delGT p.(Val1283Lysfs*2) showed cosegregation disease as well loss...
Abstract Purpose: Several studies have described molecular differences between microsatellite stable hereditary nonpolyposis colorectal cancer (MSS-HNPCC) and unstable Lynch syndrome tumors (MSI-HNPCC). These highlight the possibility that other instability forms could explain susceptibility in this group of families. The base excision repair (BER) pathway is major DNA for oxidative damage. A defect can result transversion mutations a subsequent increased risk. Mutations MUTYH been...
Abstract Background & Aims Bone morphogenetic protein 9 ( BMP 9) interferes with liver regeneration upon acute injury, while promoting fibrosis carbon tetrachloride‐induced chronic injury. We have now addressed the role of in 3,5 diethoxicarbonyl‐1,4 dihydrocollidine DDC )‐induced cholestatic a model mediated by hepatic progenitor cell (known as oval cell), exemplified ductular reaction and expansion. Methods WT KO mice were submitted to diet. Livers examined for fibrosis, inflammation...
Despite the well-known hepatoprotective role of epidermal growth factor receptor (EGFR) pathway upon acute damage, its specific actions during chronic liver disease, particularly cholestatic injury, remain ambiguous and unresolved. Here, we analyzed consequences inactivating EGFR signaling in on regenerative response following injury. For that, transgenic mice overexpressing a dominant negative mutant human lacking tyrosine kinase activity (ΔEGFR) albumin-positive cells were submitted to...