A5109399803- Nanoparticle-Based Drug Delivery
- Liver Disease Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- Nanoplatforms for cancer theranostics
- Diet, Metabolism, and Disease
- Liver Disease and Transplantation
- Graphene and Nanomaterials Applications
- Curcumin's Biomedical Applications
- Traditional Chinese Medicine Studies
- Natural Antidiabetic Agents Studies
- Traditional Chinese Medicine Analysis
- Ginseng Biological Effects and Applications
- PARP inhibition in cancer therapy
- Photodynamic Therapy Research Studies
- Free Radicals and Antioxidants
- Polysaccharides Composition and Applications
- Polysaccharides and Plant Cell Walls
- Advanced biosensing and bioanalysis techniques
- Lipid metabolism and disorders
- Liver physiology and pathology
- Plant-based Medicinal Research
- Chronic Lymphocytic Leukemia Research
- Ion Transport and Channel Regulation
- Advanced Breast Cancer Therapies
- Calcium signaling and nucleotide metabolism
Yunnan University
2019-2025
Yunnan University of Traditional Chinese Medicine
2012-2025
Yunnan Provincial Department of Education
2025
Hunan University of Traditional Chinese Medicine
2023
China Aerodynamics Research and Development Center
2022
Xuefu Zhuyu Capsule (XFZYC) plays a pivotal role in treating coronary heart disease (CHD) because of its potent clinical effects and fewer side effects. However, the possible pharmacological effect on CHD is limited. Thus, this research systematically analyzes XFZYC through network pharmacology technology. We identified 139 active compounds 127 overlapped target genes 11 herbs by using pharmacology, these regulated major signaling pathways related to CHD. The analysis protein-protein...
Abstract Background Diabetes complications are the leading cause of mortality in diabetic patients. The common decline antioxidant capacity and onset micro-inflammation syndrome. At present, glucose-responsive nanoparticles widely used, as they can release insulin-loaded ultrafine particles intelligently effectively reduce blood sugar. However, toxicology this method has not been fully elucidated. plant extracts pterostilbene (PTE) have a wide range biological applications, such...
In this study, we investigated the effect of Shenling Baizhu San(SLBZS), Quzhi Ruangan Fang(QZRGF) and Gexia Zhuyu Tang(GXZYT) on intestinal flora NAFLD rats through network pharmacology experimental validation. Protein-protein interaction, Gene Ontology (GO), molecular docking were performed. Male Sprague-Dawley (SD) divided into 6 groups: Normal, Model, SLBZS (7.2g/kg), QZRGF (27.72g/kg), GXZYT (28.8 g/kg) positive control (Fenofibrate, 18mg/kg); model was established by High-fat diet....
An insulin delivery system that self-regulates blood sugar levels, mimicking the human pancreas, can improve hyperglycaemia. At present, a glucose-responsive combining AAPBA with long-acting slow release biomaterials has been developed. However, safety of sustained-release materials and challenges preventing diabetic complications remain. In this study, we developed novel polymer material using plant extract-p-hydroxyphenylethyl anisate (HPA). After block copolymerisation AAPBA, prepared...
Non-alcoholic fatty liver disease (NAFLD) is characterised by the excessive accumulation of triglycerides in liver. Shenling Baizhu powder (SLBZP) formulated from various natural medicinal plants that protect and are used to treat intestinal diseases. SLBZP improves symptoms NAFLD. However, its mechanism action remains unclear. Herein, we investigated ameliorative effect on model mice with high-fat-diet (HFD)-induced Additionally, evaluated impact flora metabolites mitochondrial energy...
Compared with random copolymers, block copolymerization is easier to prepare for nanoparticles core-shell structure, and they will have better glucose sensitivity higher insulin loading.In our study, insulin-loaded poly (3-acrylamidophenylboronic acid-block-N-vinyl caprolactam) p(AAPBA-b-NVCL) were successfully prepared glucose-sensitive, which could effectively lower the blood sugar levels within 72 hrs.The polymer of was produced by reversible addition-fragmentation chain transfer...
At present, tumors are leading cause of death. Biomimetic nanocarriers for precision cancer therapy attracting increasing attention. Nanocarriers with a good biocompatible surface could reduce the recognition and elimination nanoparticles as foreign substances by immune system, offer specific targeting, improve efficacy medicine tumors, thereby providing outstanding prospects application in therapy. In particular, cell membrane biomimetic camouflaged have become research hotspot because...
In this study, a pH-responsive controlled-release mesoporous silica nanoparticle (MSN) formulation was developed. The MSNs were functionalized with histidine (His)-tagged targeting peptide (B3int) through an amide bond, and loaded anticancer drug (cisplatin (CP)) lysosomal destabilization mediator (chloroquine (CQ)). Cu2+ then used to seal the pores of via chelation His-tag. resultant nanoparticles showed release, could effectively target tumor cells effect B3int. presence CP permits...
The Na+/K+-ATPase α1 subunit (ATP1A1) is a potential target for hepatic carcinoma (HCC) treatment, which plays key role in Na+/K+ exchange, metabolism, signal transduction, etc. In vivo, we found that Panax notoginseng saponins (PNS) could inhibit tumor growth and significantly downregulate the expression phosphorylation of ATP1A1/AKT/ERK tumor-bearing mice. Our study aims to explore effects PNS on regulation ATP1A1 possible mechanisms antitumor activity. HepG2 cell viability, migration,...
Non-alcoholic fatty liver disease(NAFLD), as a metabolic stress injury disease, is one of the most common chronic diseases, which seriously threatens people's health. The pathogenesis NAFLD very complex. A large number studies show that hepatic mitochondrial dysfunction leads to disorder glucose and lipid metabolism, oxidative stress, inflammation, thus inducing hepatocyte apoptosis, plays an important role in progression NAFLD. In recent years, researchers have begun focus on developing...
Late-life anxiety has a high prevalence and usually co-morbidity with cerebral- cardiovascular diseases which in turn increases the disability mortality old people. The pathology of late-life is difference from adult character GABAergic neuroplasticity dysfunction. therapeutic strategy presently can only alleviate anxious symptom but not ameliorate neuroplasticity. Brain-derived neurotrophic factor (BDNF) critical signaling molecule regulates neuroplasticity, reduction BDNF along aging...
Ethnopharmacological relevance: Jian-Pi-Ruan-Gan Formula (JPRG) is a traditional Chinese medicine formula composed of six herbal medicines. Clinical and several experimental studies have found that JPRG has pharmacological effects on fibrosis in non-alcoholic fatty liver disease (NAFLD).Aim the study: To investigate whether regulates Ras/Raf/MEK/ERK signaling pathway to attenuate collagen extracellular matrix deposition MCD diet-induced NAFLD rats observe its TGF-β1-induced LX-2...
Non-alcoholic fatty liver disease(NAFLD) is a chronic metabolic condition with rapidly increasing incidence, becoming public health issue of worldwide concern. Studies have shown that farnesoid X receptor(FXR)-based modulation downstream targets can improve function and status in the patients NAFLD may be potential drug target for treating this di-sease. Great progress has been achieved development drugs targeting FXR treatment NAFLD. A number studies explored traditional Chinese medicine...