A5113918877- Autophagy in Disease and Therapy
- Arsenic contamination and mitigation
- Primary Care and Health Outcomes
- Chronic Disease Management Strategies
- Sirtuins and Resveratrol in Medicine
- Genomics, phytochemicals, and oxidative stress
- Alzheimer's disease research and treatments
- High Altitude and Hypoxia
- Heme Oxygenase-1 and Carbon Monoxide
- Alcohol Consumption and Health Effects
- Substance Abuse Treatment and Outcomes
- MicroRNA in disease regulation
- Healthcare Systems and Technology
- Advanced Glycation End Products research
- Plant Pathogens and Fungal Diseases
- Glutathione Transferases and Polymorphisms
- Nausea and vomiting management
- Neuroscience and Neuropharmacology Research
- Aluminum toxicity and tolerance in plants and animals
- COVID-19 diagnosis using AI
- Cannabis and Cannabinoid Research
- Adipose Tissue and Metabolism
- Bioinformatics and Genomic Networks
- Mesenchymal stem cell research
- Cancer, Hypoxia, and Metabolism
China Medical University
2008-2025
Henan Provincial People's Hospital
2025
Zhengzhou University
2025
117th Hospital of People's Liberation Army
2025
Chinese People's Liberation Army
2018-2025
Tongji University
2025
Tongji Hospital
2025
Soochow University
2022-2024
Hechi University
2024
Qingdao University
2023
Nonunion is a common complication in open fractures and other severe bone injuries. Recombinant human morphogenetic protein-2 (rhBMP-2) delivered on collagen sponge enhances healing of fractures. However, the burst release rhBMP-2 necessitates supra-physiological doses to achieve robust osteogenic effect, which introduces risk ectopic formation inflammation increases cost. Although concept that ideal pharmacokinetics for includes both sustained generally accepted, investigations into effects...
Amyloid-beta clearance plays a key role In the pathogenesis of Alzheimer's disease. However, variation in functional proteins involved amyloid-beta and their correlation with levels remain unclear. this study, we conducted meta-analyses systematic review using studies from PubMed, Embase, Web Science, Cochrane Library databases, including journal articles published inception to June 30, 2023. The inclusion criteria included comparing associated blood, cerebrospinal fluid, brain healthy...
Jiaojiao Yin, Yuhang Wang, Bing Li, Xiaoyan Hu, Yao Ma, Chong Zhang, Xiaoqin Ha, Linyan and Yaozhu Pan. Hypobaric hypoxia increased autophagy apoptosis in PC12 rat pheochromocytoma cells more than normobaric hypoxia. High Alt Med Biol. 00:00-00, 2025. Purpose: Currently, vitro studies have focused on injury acute mountain sickness (AMS), but little effort has been made to assess the effects of hypobaric AMS is a neurological disorder, (PC12) are model study neuronal survival apoptosis. Here,...
Purpose: This study investigates the role of EFEMP1 in choroidal vascular dysfunction and its implications for myopia progression, specifically focusing on FOXO3/VEGFA signaling pathway as a potential therapeutic target. Methods: We utilized adeno-associated virus (AAV) to overexpress knock down choroid guinea pigs. Subsequent proteomic analyses were conducted tissue. used Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) identify relevant pathways genes. In vitro experiments...
Background In China, clinical deterioration events present a real problem for every nurse. Patient is determined in part by nurses’ attitudes toward early recognition of deterioration. However, research on the identification still its infancy, and even less has been done ward To drive behavioral change improve care deteriorating patients, nurses need comprehensive, valid, reliable tools to assess their Objective this study, we aimed translate Attitudes Toward Recognizing Early Noticeable...
Purpose To explore the possible molecular mechanism by which epidermal growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1) regulates choroid thickness (CT) in development of myopia. Methods In total, 131 subjects were divided into emmetropia (EM) group, non-high myopia (non-HM) group and high (HM) group. Their age, refraction, intraocular pressure, other ocular biometric parameters collected. A 6 × mm area centered on optic disc was scanned coherent optical...
Background Stigma is an important psychological concept that being studied in many diseases. However, there have been few studies on stigma renal dialysis patients China. This study aimed to investigate the level of and its potential influencing factors among Chinese patients. Methods A cross-sectional was conducted two centers between April 2022 July 2022. Two hundred four kidney were interviewed with a questionnaire demographic variables using Social Impact Scale (SIS), Resilience Scale-14...
Abstract Myocardial ischemia/reperfusion (I/R) injury detrimentally alters the prognosis of patients undergoing revascularization after acute myocardial infarction. Our previous study demonstrated that NF-κB-induced autophagy plays a detrimental role in cardiac I/R using rabbit model. In this study, we sought to explore specific mechanism autophagy-mediated cell damage an vitro simulated (sI/R) model human umbilical vein endothelial cells. current demonstrates induces p65-Beclin 1-dependent...
Ischemic stroke is a common cerebrovascular disease caused by insufficient blood supply to the brain. In recent years, studies have demonstrated that microRNAs (miRNAs) are involved in variety of biological processes nervous system. However, effects miR-202-5p on cerebral ischemic injury not been completely elucidated. our study, N2a cells were subjected oxygen-glucose deprivation/reoxygenation (OGD/R) treatment, and middle artery occlusion (MCAO) rat models constructed. Our results...
Arsenic is a toxic metalloid, which also compromises immunity and causes various immunological disorders. Exposure to arsenic exerts the immunosuppressive properties of dendritic cells (DCs). Autophagy self-renewal process cells, degrades damaged macromolecules organelles through lysosomal pathway. Thus, herein, we attempt clarify impacts autophagy autophagy-lysosome pathway on arsenic-exposed DCs. Bone marrow-derived (BMDCs) were exposed different concentrations (0.25, 0.5 1 μM) with or...
Glioma is a malignant tumor of the glial tissue that difficult to excise through surgery, with poor patient prognosis. The use chemotherapeutic drugs alone treat glioma following surgery results in high probability sequelae, such as recurrence. present study investigated effects novel treatment combination on cells and determined molecular mechanisms underlying its action. effect temozolomide (TMZ) combined rapamycin (RAPA) TMZ-induced autophagic death U251 was examined. cell line treated...
The senescence of mesenchymal stem cells (MSCs) impairs their regenerative capacity to maintain tissue homeostasis. Numerous studies are focusing on the interventions and mechanisms attenuate MSCs. C-phycocyanin (C-PC) is reported have multiple functions such as antitumor, antioxidation, anti-inflammation anti-aging roles, but there little research about effects C-PC Here we investigated roles mechanism MSCs senescence. <i>In vitro </i>results showed that could reduce senescence, enhance...
Abstract Background This study examined associations between body composition and physical fitness scores among medical students in Shenyang, China. Methods A total of 2291 aged 18–20 (815 male 1476 female) Shenyang China were recruited to participate the research May 2019. With use BCA-1B analyzer standard method assessment, seven measures (body mass index, vital capacity, sit reach, standing long jump, pull-ups/crunches, 50-m sprint, 800/1000-m run) college measured, respectively. The...
Neddylation is a post-translational protein modification process. MLN4924 newly discovered pharmaceutical neddylation inhibitor that suppresses cancer growth with several types. In our study, we first investigated the effect of on colon cells (HCT116 and HT29). significantly inhibited cullin-1 cell in time dose-dependent manner. induced G2/M cycle arrest apoptosis HCT116 HT29 cells. Moreover, also triggered autophagy via suppressing PI3K/AKT/mTOR pathway. Inhibiting by 3-MA or ATG5 knockdown...