A5034833341- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Antibiotic Resistance in Bacteria
- Clostridium difficile and Clostridium perfringens research
- Antibiotic Use and Resistance
- COVID-19 Clinical Research Studies
- Pneumonia and Respiratory Infections
- SARS-CoV-2 and COVID-19 Research
- Urinary Tract Infections Management
- Streptococcal Infections and Treatments
- Sepsis Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Emergency and Acute Care Studies
- Long-Term Effects of COVID-19
- Infection Control in Healthcare
- Viral gastroenteritis research and epidemiology
- Antibiotics Pharmacokinetics and Efficacy
- Mycobacterium research and diagnosis
- Escherichia coli research studies
- Respiratory viral infections research
- Influenza Virus Research Studies
- Total Knee Arthroplasty Outcomes
- Microscopic Colitis
- COVID-19 diagnosis using AI
- Enterobacteriaceae and Cronobacter Research
Research Network (United States)
2017-2024
Providence College
2017-2024
Renton Technical College
2022
St. Joseph Health System
2017-2021
Museum of Heilongjiang Province
2020
NorthShore University HealthSystem
2008-2017
Providence Health & Services
2017
Engineering Associates (United States)
2017
University of Chicago
2009-2016
Institute for Clinical Evaluative Sciences
2013
Among 313 Enterobacteriaceae from the United States with a ciprofloxacin MIC of >/=0.25 microg/ml and reduced susceptibility to ceftazidime, aac(6')-Ib was present in 50.5% isolates, these, 28% carried cr variant responsible for low-level resistance. aac(6')-Ib-cr geographically widespread, stable over time, most common Escherichia coli, equally prevalent ciprofloxacin-susceptible -resistant strains, not associated qnr genes.
We screened 313 ceftazidime-resistant Enterobacteriaceae isolates obtained in the United States from 1999 to 2004 for all three known qnr genes. A gene was present 20% of Klebsiella pneumoniae isolates, 31% Enterobacter sp. and 4% Escherichia coli isolates. qnrA qnrB occurred with equivalent frequencies and, except enterobacters, were stable over time. qnrS absent.
The effect of large-scale expanded surveillance for methicillin-resistant Staphylococcus aureus (MRSA) on health care-associated MRSA disease is not known.To examine the 2 interventions disease.Observational study comparing rates clinical during and after hospital admission in 3 consecutive periods: baseline (12 months), all admissions to intensive care unit (ICU) universal (21 months).A 3-hospital, 850-bed organization with approximately 40,000 annual admissions.Polymerase chain...
This study investigates the incidence of myocarditis and pericarditis emergency department or inpatient hospital encounters before COVID-19 vaccine availability (January 2019–January 2021) during a vaccination period (February-May in large US health care system.
A novel plasmid-mediated quinolone resistance gene, qnrB, has been discovered in a plasmid encoding the CTX-M-15 beta-lactamase from Klebsiella pneumoniae strain isolated South India. It less than 40% amino acid identity with original qnr (now qnrA) gene or recently described qnrS but, like them, codes for protein belonging to pentapeptide repeat family. Strains qnrB demonstrated low-level all quinolones tested. The cloned an expression vector attaching polyhistidine tag, which facilitated...
Background. Fluoroquinolone-resistant Escherichia coli are increasingly prevalent. Their clonal origins—potentially critical for control efforts—remain undefined.
Rationale: Most ward risk scores were created using subjective opinion in individual hospitals and only use vital signs.Objectives: To develop validate a score commonly collected electronic health record data.Methods: All patients hospitalized on the wards five included this observational cohort study. Discrete-time survival analysis was used to predict combined outcome of cardiac arrest (CA), intensive care unit (ICU) transfer, or death wards. Laboratory results, signs, demographics as...
Abstract Digital pathology poses unique computational challenges, as a standard gigapixel slide may comprise tens of thousands image tiles 1–3 . Prior models have often resorted to subsampling small portion for each slide, thus missing the important slide-level context 4 Here we present Prov-GigaPath, whole-slide foundation model pretrained on 1.3 billion 256 × in 171,189 whole slides from Providence, large US health network comprising 28 cancer centres. The originated more than 30,000...
Serious infections with Salmonella species are often treated fluoroquinolones or extended-spectrum beta-lactams. Increasingly recognized in Enterobacteriaceae, plasmid-mediated quinolone resistance is encoded by qnr genes. Here, we report the presence of variants human isolates non-Typhi serotypes enterica (hereafter referred to as Salmonella) from United States National Antimicrobial Resistance Monitoring System for Enteric Bacteria.All specimens Bacteria collected 1996 2003 ciprofloxacin...
Background. Clostridium difficile-associated diarrhea (CDAD) is the major cause of health care-associated infectious diarrhea. Current laboratory testing lacks a single assay that sensitive, specific, and rapid. The purpose this work was to design validate sensitive specific real-time polymerase chain reaction (PCR) diagnostic test for CDAD. Methods. This observational validation study new PCR occurred from July 2004 through April 2006 involved 1368 stool samples. As final portion...
Objectives: The subjectivity and complexity of surveillance definitions for ventilator-associated pneumonia preclude meaningful internal or external benchmarking therefore hamper quality improvement initiatives ventilated patients. We explored the feasibility creating objective pneumonia. Design: identified clinical signs suitable inclusion in definitions, proposed candidate incorporating these signs, then applied to retrospective data measure their frequencies associations with adverse...
ABSTRACT We assessed Escherichia coli ST131 and its H30 H30-Rx subclones for virulence genes, antimicrobial resistance, extended-spectrum beta-lactamase (ESBL) type. Although both were associated with ESBL production, isolates had higher resistance scores specifically CTX-M-15. Three genes ( iha , sat iutA ) more prevalent among than non-H30 isolates. Thus, the are resistant have profiles that distinct from those of
ABSTRACT Escherichia coli sequence type ST131 (from phylogenetic group B2), often carrying the extended-spectrum-β-lactamase (ESBL) gene bla CTX-M-15 , is an emerging globally disseminated pathogen that has received comparatively little attention in United States. Accordingly, a convenience sample of 351 ESBL-producing E. isolates from 15 U.S. centers (collected 2000 to 2009) underwent PCR-based phylotyping and detection . A total 200 isolates, comprising 4 groups 50 each were (i) negative...
Allergy documentation is frequently inconsistent and incomplete. The impact of this variability on subsequent treatment not well described.To determine how allergy affects antibiotic choice.Retrospective, cohort study.232,616 adult patients seen by 199 primary care providers (PCPs) between January 1, 2009 2014 at an academic medical system.Inter-physician variation in beta-lactam documentation; following documentation.15.6% had a reported allergy. Of those patients, 39.8% specific allergen...
We evaluated the use of BD GeneOhm MRSA real-time PCR assay (BD Diagnostics, San Diego, CA) for detection nasal colonization with methicillin-resistant Staphylococcus aureus (MRSA). The initial evaluation consisted 403 paired swabs and was done using specimen preparation provided kit an in-house lysis method that specifically developed to accommodate large-volume testing a minimal amount personnel time. One swab placed in achromopeptidase (ACP) solution, other first used culture then...
The duration of colonization with methicillin-resistant Staphylococcus aureus is not well defined. During 1564 admissions after a clinical culture or surveillance test positive for aureus, we retested patients colonization. the first year result was obtained, 48.8% (95% confidence interval, 45.8%-51.7%) remained colonized; at 4 years, 21.2% 13.1%-31.4%) colonized.
Objective. We evaluated the usefulness of topical decolonization therapy for reducing risk methicillin-resistant Staphylococcus aureus (MRSA) infection among MRSA-colonized inpatients. Design. Retrospective cohort study. Setting and Intervention. Three hospitals with universal surveillance MRSA; at their physician's discretion, colonized patients could be treated a 5-day course nasal mupirocin calcium 2%, twice daily, plus Chlorhexidine gluconate 4% every second day. Patients Methods. MRSA...