A5056776375- Clostridium difficile and Clostridium perfringens research
- Urinary Tract Infections Management
- Infection Control and Ventilation
- Infection Control in Healthcare
- Bacterial Identification and Susceptibility Testing
- COVID-19 and healthcare impacts
- Surgical site infection prevention
- Antibiotic Use and Resistance
- Nosocomial Infections in ICU
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Resistance in Bacteria
- Medical Device Sterilization and Disinfection
- Healthcare cost, quality, practices
- Mycobacterium research and diagnosis
- Central Venous Catheters and Hemodialysis
- Patient Satisfaction in Healthcare
- Sepsis Diagnosis and Treatment
- Microscopic Colitis
- Cardiac, Anesthesia and Surgical Outcomes
- Orthopedic Infections and Treatments
- SARS-CoV-2 detection and testing
- Viral gastroenteritis research and epidemiology
- Pressure Ulcer Prevention and Management
- Clinical practice guidelines implementation
- Respiratory viral infections research
Duke University
2015-2025
Duke Medical Center
2017-2024
Duke University Hospital
2018-2024
Oregon Medical Research Center
2023-2024
University of Pittsburgh
2024
Communities In Schools of Orange County
2023-2024
New York Proton Center
2023-2024
Lindsay Unified School District
2023-2024
University of Oxford
2021-2023
University Hospitals Plymouth NHS Trust
2023
Clostridium difficile infection (CDI) in the elderly has a higher prevalence, greater morbidity and mortality, lower response to conventional treatment than general population. Fecal microbiota transplant (FMT) is highly effective therapy for CDI but not been studied specifically elderly. This study aims determine long-term efficacy safety of FMT recurrent (RCDI), severe (SCDI), complicated (CCDI) patients.A multicenter, follow-up was performed with demographic, pre-FMT, post-FMT data...
Applied BiosafetyVol. 25, No. 2 Letters to the EditorFree AccessDecontamination and Reuse of N95 Respirators with Hydrogen Peroxide Vapor Address Worldwide Personal Protective Equipment Shortages During SARS-CoV-2 (COVID-19) PandemicAntony Schwartz, Matthew Stiegel, Nicole Greeson, Andrea Vogel, Wayne Thomann, Monte Brown, Gregory D. Sempowski, Thomas Scott Alderman, James Patrick Condreay, Burch, Cameron Wolfe, Becky Smith, Sarah LewisAntony SchwartzCorresponding Author: Antony Duke...
ABSTRACT Pediatric patients undergoing cardiothoracic surgery are at increased risk for health care–associated infections, especially surgical site infections (SSIs). Delayed sternal closures associated with prolonged lengths of stay and contribute to infection risks morbidities. At a single‐site academic pediatric center, we created an SSI‐prevention bundle targeting the preoperative, intraoperative, postoperative care periods. Using standard criteria, determined epidemiology SSIs measured...
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BACKGROUND Influenza A (H1N1) pdm09 became the predominant circulating strain in United States during 2013–2014 influenza season. Little is known about epidemiology of severe this METHODS retrospective cohort study severely ill patients with infection intensive care units 33 US hospitals from September 1, 2013, through April 2014, was conducted to determine risk factors for mortality present on unit admission and describe patient characteristics, spectrum disease, management, outcomes....
Abstract Background Patient room sinks are frequently identified as potential sources for hospital-associated infections (HAIs), but there no clear recommendations interventions to reduce sink-related pathogenic bioburden. We conducted one of the first longitudinal crossover trials assess impact practical sink in an academic hospital.Figure 1.Contamination levels patient p-trap and tap water between units over time.Black lines represent samples with CFU/mL above limit detection. Methods a...
Abstract Background Different societies and organizations use different surgical site infection (SSI) definitions for surveillance. With multiple in use, validation of surveillance findings becomes paramount, particularly maintaining surgeon buy-in during data review developing countermeasures. The goal our study was to assess concordance between SSI diagnoses following peripheral vascular bypass (PVBY) surgery derived from by a (vascular) those identified through performed the prevention...
Abstract Background Surgical site infections (SSI) complicate 4.8-12.4% of orthotopic heart transplants (OHT) and result in increased length hospital stay, mortality, health care costs. As such, the need for accurate SSI surveillance systems OHT is critical. This study aimed to evaluate diagnostic accuracy National Healthcare Safety Network (NHSN) Society Thoracic Surgeons (STS) against gold standard a detailed manual adjudication process performed by Transplant ID physicians (TXID). Methods...
Abstract Background Guidelines recommend performing hand hygiene (HH) prior to donning non-sterile gloves, yet strong evidence is lacking and overall adherence low. This study evaluated the impact of different HH gloving strategies on glove contamination. Methods Healthcare personnel (HCP) were enrolled inpatient units then randomized into 3 arms: 1) standard practice alcohol-based rub (AHBR) before gloving, 2) ABHR after or 3) direct without HH. Study first collected 1 control per HCP from...
Mucormycosis outbreaks have been linked to contaminated linen. We performed fungal cultures on freshly-laundered linens at 15 transplant and cancer hospitals. At 33% of hospitals, the were visibly unclean. 20%, Mucorales recovered from >10% linens. Studies are needed understand clinical significance our findings.
Abstract Objective: Sparse recent data are available on the epidemiology of surgical site infections (SSIs) in community hospitals. Our objective was to provide updated complex SSIs hospitals and characterize trends SSI prevalence rates over time. Design: Retrospective cohort study. Methods: were collected from patients undergoing 26 commonly performed procedures at 32 southeastern United States 2013 2018. calculated for each year stratified by procedure causative pathogen. Results: Over...
Abstract This retrospective review of 4-year surveillance data revealed a higher central line-associated bloodstream infection (CLABSI) rate in non-Hispanic Black patients and catheter-associated urinary tract (CAUTI) rates Asian compared with White despite similar catheter utilization between the groups.
S ummary : The addition of 50 μg sulphamezathine/ml to egg‐tellurite‐glycine‐pyruvate agar was effective in suppressing the growth and swarming Proteus spp. Small numbers Staphylococcus aureus (10 3 /g) could be recovered quantitatively on modified medium presence up 10 6 /g mixed vulgaris mirabilis strains.
Abstract We assessed environmental contamination of inpatient rooms housing coronavirus disease 2019 (COVID-19) patients in a dedicated COVID-19 unit. Contamination with severe acute respiratory syndrome 2 was found on 5.5% (19/347) surfaces via reverse transcriptase polymerase chain reaction and 0.3% (1/347) cell culture. Environmental is uncommon hospitals rooms; RNA presence not specific indicator infectious virus.
Objective To implement complex, PINCER (pharmacist led information technology intervention) prescribing indicators, on a national scale with general practice data to describe the impact of covid-19 pandemic safe prescribing. Design Population based, retrospective cohort study using federated analytics. Setting Electronic health record from 56.8 million NHS patients by use OpenSAFELY platform, approval National Health Service (NHS) England. Participants (aged 18-120 years) who were alive and...
Abstract Background The weighted incidence syndromic combination antibiogram (WISCA) is an antimicrobial stewardship tool that utilizes electronic medical record data to provide real-time clinical decision support regarding empiric antibiotic prescription in the hospital setting. aim of this study was determine impact WISCA utilization for on length stay (LOS). Methods We performed a crossover randomized controlled trial at 4 hospitals. Study participants included adult inpatients receiving...
Abstract Objective: Urine cultures collected from catheterized patients have a high likelihood of false-positive results due to colonization. We examined the impact clinical decision support (CDS) tool that includes catheter information on test utilization and patient-level outcomes. Methods: This before-and-after intervention study was conducted at 3 hospitals in North Carolina. In March 2021, CDS incorporated into urine-culture order entry electronic health record, providing education...
Abstract Background: The origins and timing of inpatient room sink contamination with carbapenem-resistant organisms (CROs) are poorly understood. Methods: We performed a prospective observational study to describe the timing, rate, frequency CRO in-room handwashing sinks in 2 intensive care units (ICU) newly constructed hospital bed tower. Study units, A B, were opened patient succession. patients unit moved new same tower, B. Each was similarly designed 26 rooms sinks. Microbiological...
Surgical site infections (SSI, including wound infections, endometritis, pelvic abscess, and sepsis) may complicate cesarean section (C/S). We report outcomes before after the introduction of an SSI prevention bundle that did not include antibiotics beyond routine prophylaxis (cefazolin, or gentamicin/clindamycin for penicillin-allergic patients).The was introduced following increase in C/S-associated SSI, which itself associated with institutional switch preoperative scrub from...