A5055592114- Mesenchymal stem cell research
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- Neonatal Respiratory Health Research
- vaccines and immunoinformatics approaches
- Immune cells in cancer
- T-cell and B-cell Immunology
- COVID-19 Clinical Research Studies
- CAR-T cell therapy research
- Tissue Engineering and Regenerative Medicine
- Bone Tissue Engineering Materials
- Periodontal Regeneration and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Hematopoietic Stem Cell Transplantation
- Corneal Surgery and Treatments
- Osteoarthritis Treatment and Mechanisms
- Adrenal Hormones and Disorders
- Neurogenesis and neuroplasticity mechanisms
- Medical Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Congenital Diaphragmatic Hernia Studies
Pfizer (Italy)
2024-2025
University of Verona
2011-2014
Murine syngeneic tumor models are critical to novel immuno-based therapy development, but the molecular and immunologic features of these still not clearly defined. The translational relevance differences between is fully understood, impeding appropriate preclinical model selection for target validation, ultimately hindering drug development. Across a panel commonly used murine models, we showed variable responsiveness immunotherapies. We array comparative genomic hybridization, whole-exome...
Clinical-grade mesenchymal stromal cells (MSCs) are usually expanded from bone marrow (BMMSCs) or adipose tissue (ADSCs) using processes mainly differing in the use of fetal calf serum (FCS) human platelet lysate (PL). We aimed to compare immune modulatory properties clinical-grade MSCs a combination fully standardized vitro assays. BMMSCs with FCS (BMMSC-FCS) PL (BMMSC-PL), and ADSC-PL were analyzed quantitative phenotypic functional experiments, including their capacity inhibit...
Stromal cells are essential components of the bone marrow (BM) microenvironment that regulate and support survival different tumors, including chronic lymphocytic leukemia (CLL). In this study, we investigated role Notch signaling in promotion chemoresistance human CLL coculture with BM-mesenchymal stromal (hBM-MSCs) both autologous allogeneic origin. The presence BM-MSCs rescued from apoptosis spontaneously following induction various drugs, Fludarabine, Cyclophosphamide, Bendamustine,...
Allogeneic stem cell (SC)-based therapy is a promising tool for the treatment of range human degenerative and inflammatory diseases. Many reports highlighted immune modulatory properties some SC types, such as mesenchymal stromal cells (MSCs), but comparative study with SCs different origin, to assess whether regulation general property, still lacking. To this aim, we applied highly standardized methods employed MSC characterization compare immunological bone marrow-MSCs, olfactory...
Mesenchymal stromal cells (MSCs) reside in many organs including lung, as shown by their isolation from fetal lung tissues, bronchial compartment, bronchial-alveolar lavage and transplanted tissues. It is still controversial whether MSCs can undergo mesenchymal-to-epithelial-transition (MET) possess immune regulatory properties. To this aim, we isolated, expanded characterized normal adult human (lung-hMSCs) compared with bone marrow-derived (BM-hMSCs). Our results show that lung-MSCs at the...
Death receptor (DR3) 3 is a member of the TNFR superfamily. Its ligand TNF-like 1A (TL1A), TNF TL1A/DR3 interactions have been reported to modulate functions T cells, NK, and NKT cells play crucial role in driving inflammatory processes several T-cell-dependent autoimmune diseases. However, TL1A expression effects on B remain largely unknown. In this study, we described for first time that from human blood express significant amounts DR3 response cell polyclonal stimulation. The relevance...
<div>Abstract<p>Murine syngeneic tumor models are critical to novel immuno-based therapy development, but the molecular and immunologic features of these still not clearly defined. The translational relevance differences between is fully understood, impeding appropriate preclinical model selection for target validation, ultimately hindering drug development. Across a panel commonly used murine models, we showed variable responsiveness immunotherapies. We array comparative genomic...
<p>Supplementary dataset containing raw data from targeted sequencing, whole exome array CGH and transcriptomic analysis</p>
<p>Supplementary dataset containing raw data from targeted sequencing, whole exome array CGH and transcriptomic analysis</p>
<div>Abstract<p>Murine syngeneic tumor models are critical to novel immuno-based therapy development, but the molecular and immunologic features of these still not clearly defined. The translational relevance differences between is fully understood, impeding appropriate preclinical model selection for target validation, ultimately hindering drug development. Across a panel commonly used murine models, we showed variable responsiveness immunotherapies. We array comparative genomic...