A5005669960- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Toxoplasma gondii Research Studies
- Galectins and Cancer Biology
- Carbohydrate Chemistry and Synthesis
- Herpesvirus Infections and Treatments
- Glycosylation and Glycoproteins Research
- HIV Research and Treatment
- Bacteriophages and microbial interactions
- Enzyme Production and Characterization
- Celiac Disease Research and Management
- T-cell and Retrovirus Studies
- Potato Plant Research
- Mitochondrial Function and Pathology
- RNA and protein synthesis mechanisms
- Plant Parasitism and Resistance
- Asthma and respiratory diseases
- Enzyme-mediated dye degradation
- Evolution and Genetic Dynamics
- Plant and animal studies
- Plant Pathogens and Fungal Diseases
- Mycotoxins in Agriculture and Food
- Nuclear Structure and Function
Center for Infection and Immunity of Lille
2017-2024
Institut Pasteur de Lille
2018-2024
Centre Hospitalier Universitaire de Lille
2018-2024
Université de Lille
2013-2024
Inserm
2013-2024
Centre National de la Recherche Scientifique
2010-2024
Lille Inflammation Research International Center
2015
Université Lille Nord de France
2013
Université Paris-Sud
2010
Écologie, Systématique et Évolution
2010
Despite the fact that Candida albicans is an important human fungal pathogen and Dectin-2 a major pattern recognition receptor for fungi, our knowledge regarding role of host defense against disseminated candidiasis limited. deficient (Dectin-2−/−) mice were more susceptible to systemic candidiasis, susceptibility was mirrored by elevated load in kidneys correlated with presence large inflammatory foci. Phagocytosis macrophages lacking moderately decreased, while production most...
Toxoplasma gondii virulence depends on the expression of factors packed into specific organelles such as rhoptry and microneme. Although factor is tightly regulated, molecular mechanisms controlling their regulation remain poorly understood. ApiAP2 are a family conserved transcription (TFs) that play an important role in regulating gene apicomplexan parasites. TgAP2XI-5 able to bind transcriptionally active promoters genes expressed during S/M phase cell cycle, (rhoptries micronemes genes)....
Critical determinants of the optimum level virulence in pathogens include presence competitors (i.e., multiple infections), their relatedness, and effect on pathogen growth disease development. Empirical data regarding existence competitive interactions impact remain very limited compared to theoretical studies. Here, we followed an experimental population model fungal Microbotryum lychnidis-dioicae its caryophyllaceous host Silene latifolia. Our analysis revealed conditional responses by...
Coordination between nucleus and mitochondria is essential for cell survival, thus numerous communication routes have been established these two organelles over eukaryotic evolution. One route organelle via membrane contact sites, functional appositions formed by molecular tethers. We describe a novel nuclear-mitochondrial site in the protozoan Toxoplasma gondii. identified specific contacts occurring at nuclear pore demonstrated an interaction components of mitochondrial protein translocon,...
Toxoplasma gondii is a unicellular eukaryotic pathogen that belongs to the Apicomplexa phylum, which encompasses some of deadliest pathogens medical and veterinary importance. The centrosome key organisation coordination cell cycle division apicomplexan parasites. T. possesses particular bipartite structure (outer inner cores). One main roles ensure proper karyokinesis. However, how these 2 events are coordinated still unknown in gondii, for components poorly described. To gain more insights...
Abstract β-1,2-mannosylation of Candida albicans glycoconjugates has been investigated through the identification enzymes involved in addition β-1,2-oligomannosides (β-Mans) to phosphopeptidomannan and phospholipomannan. are supposed have virulence properties that they confer these glycoconjugates. In a previous study, we showed cell wall mannoproteins (CWMPs) harbor β-Mans their O-mannosides; therefore, analyzed biosynthesis impact on virulence. this demonstrate O-mannans heterogeneous...
Candida albicans produces a complex glycosphingolipid called phospholipomannan (PLM), which is present on the cell-wall surface of yeast and shed upon contact with host cells. The glycan moiety PLM composed β-mannosides degrees polymerization up to 19 in C. serotype A. from B strains displays twofold decrease length chains. In this study we compared proinflammatory activities PLMs purified A bmt6Δ mutant albicans, whose short truncated oligomannosidic chain. We found that activate caspase-1...