A5004481055- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Cancer Immunotherapy and Biomarkers
- Radiation Effects and Dosimetry
- Neuroblastoma Research and Treatments
- Medical Imaging Techniques and Applications
- Inflammatory Biomarkers in Disease Prognosis
- Lung Cancer Research Studies
- Testicular diseases and treatments
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Cancer-related cognitive impairment studies
- Nasal Surgery and Airway Studies
- Radiation Detection and Scintillator Technologies
- Insect Pheromone Research and Control
- Lung Cancer Diagnosis and Treatment
- Cardiac tumors and thrombi
- Mesenchymal stem cell research
- Medical Imaging and Pathology Studies
- Gastrointestinal Tumor Research and Treatment
- Palliative Care and End-of-Life Issues
- Bone health and treatments
- Venous Thromboembolism Diagnosis and Management
- Sarcoma Diagnosis and Treatment
Centro Universitário UNINOVAFAPI
2023
Uninova
2023
Hospital Prof. Dr. Fernando Fonseca
2021
Instituto Português de Oncologia de Coimbra Francisco Gentil
2001-2020
Instituto Português de Oncologia Francisco Gentil
2003-2020
Hospital General Universitario Morales Meseguer
2000-2013
Instituto Superior Bissaya Barreto
2007
Background: Immunotherapy with programmed death receptor-1 (PD-1) antibodies has changed the paradigm of advanced NSCLC treatment. These checkpoint inhibitors showed better outcomes compared standard treatment but reliable predictive markers are still lacking. High pre-treatment NLR and PLR have been associated poor prognosis in several tumor types recent studies suggest a potential role also NSCLC. We thus conducted this study to evaluate prognostic significance our patients. Methods: All...
The main aim of the study was to evaluate efficacy and safety profile Nivolumab, an immune-checkpoint-inhibitor antibody, in advanced, previously treated, Non-Small Cell Lung Cancer (NSCLC) patients, a real world setting. We performed retrospective, multicentre data analysis patients who were included Portuguese Nivolumab Expanded Access Program (EAP). Eligibility criteria histologically or citologically confirmed NSCLC, stage IIIB IV, evaluable disease, sufficient organ function at least...
Monte Carlo (MC) methods are nowadays often used in the field of radiotherapy. Through successive steps, radiation fields simulated, producing source Phase Space Data (PSD) that enable a dose calculation with good accuracy. Narrow photon beams radiosurgery can also be simulated by MC codes. However, poor efficiency simulating these narrow produces PSD whose quality prevents calculating required To overcome this difficulty, multiple model was developed enhances reconstructed PSD, reducing...
In radiosurgery narrow photon beams, the depth of maximum dose in beam central axis increases as size additional collimator increases. This behavior is opposite what observed radiotherapy conventional beams. To understand this effect, experimental curves collimators were obtained for a Siemens KD2 linear accelerator 6 MV mode and shift varied from 5 mm to 23 collimator. Monte Carlo simulations showed that photons had no interactions collimators, contributing more than 90% total water,...
A method based on penumbra measurements and not light field, is proposed for the calibration of Siemens 82‐leaf Optifocus multileaf collimator (MLC). The were performed using MLCSoft version 1.2.0.4. (PTW‐Freiburg, Germany), which a software tool LA48 measuring system (a linear array 47 liquid‐ionization chambers). new leaf positions each banks are calculated from results an external spreadsheet. Using MLC directly in terms dosimetry settings with improved precision. nominal resulting...
A diabetes mellitus tipo 2 (DM2) é uma condição metabólica caracterizada principalmente pela resistência à insulina e pelo aumento dos níveis de glicose no sangue. As células-tronco mesenquimais (CTMs) são células multipotentes com capacidade diferenciação em tecidos possivelmente não mesenquimais, destacando-se por sua plasticidade propriedades imunomoduladoras. Diante desse contexto, essa revisão literatura formato integrativo objetivo-se selecionar material literário nas bases dados...
Abstract Background: Recent data support the modulation of immune response in breast cancer microenvironment by neoadjuvant chemotherapy. This might favor treatment and modify post-treatment tumor immunosurveillance. The association TIL with outcome after (BC) NCT has also been suggested several studies. Thereby, differences NCT-induced changes could reflect different profiles translate into diverse prognosis. objective our study was to evaluate predictive prognostic value patients BC....
A saúde dos dentes de leite é crucial para a qualidade vida infantil, mas cárie comum e pode levar tratamentos complexos. Problemas como colaboração das crianças complexidade canais radiculares dificultam o tratamento. Assim, instrumentação mecânica preferida às limas manuais, pois limpa melhor os canais, acelera tratamento cria mais uniformes previsíveis. Este estudo se propõe revisar as vantagens desvantagens do uso da mecanizada no decíduos, com base em artigos científicos fontes...
The present paper describes the study done on dosimetric characteristics of Varian Clinac 600C dynamic wedges (DW) and their comparison with physical (PW) in terms differences affecting dose distributions, beam spectra, energy fluence angular distributions. geometry 4 MV photon distributions a water phantom were simulated GEANT3 DPM Monte Carlo code systems. DW was modelled through constant movement upper jaws. depth lateral profiles for DW, PW open fields measured compared simulations...
Introduction: Gastrointestinal stromal tumor (GIST) is the most common sarcoma accounting for 18% of all sarcomas. It can occur anywhere along gastrointestinal tract, but mostly in stomach and small bowel. Historically, GISTs are aggressive tumors with poor prognosis. Imatinib first line therapy GIST patients unresectable, recurrent, or metastatic disease. Methods: We collected to our analysis treated imatinib between November/2002 February/2018. Clinical, pathological molecular...
Abstract A 34-year-old male patient was diagnosed with undifferentiated sarcoma of the right thigh, lung metastasis. He underwent primary lesion resection surgery and initiated chemotherapy both doxorubicin ifosfamide. Though tumor burden substantially reduced, secondary lesions were found to be irresponsive drug therapy, leading regimen switching gemcitabine docetaxel. Three months later, started complaining atypical chest pain palpitations. Electrocardiography revealed very frequent...
This work aims to present a case report with the use of poly-L-lactic acid for facial rejuvenation, aiming restore loss soft tissue volume resulting from natural aging process.The patient underwent treatment in 2018.The product was reconstituted 6 ml saline, left stand period 48 hours and at time application 2 2% lidocaine without vasocontritor were added.The individualized according patient's specific contour.The results analyzed using pre-and post-procedure photographs taking into account...