A5100364852- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- Circular RNAs in diseases
- Pancreatic and Hepatic Oncology Research
- Phagocytosis and Immune Regulation
- Nanoplatforms for cancer theranostics
- FOXO transcription factor regulation
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Cardiac Fibrosis and Remodeling
- Biosensors and Analytical Detection
- Molecular Junctions and Nanostructures
- Cardiovascular Disease and Adiposity
- NF-κB Signaling Pathways
- Supramolecular Self-Assembly in Materials
Air Force Medical University
2023
Xijing Hospital
2023
Chinese Academy of Sciences
2023
Zhejiang Cancer Hospital
2023
Shanghai University
2020-2023
Hunan University
2019-2020
State Key Laboratory of Chemobiosensing and Chemometrics
2020
Changsha University
2020
Cancer Hospital of Chinese Academy of Medical Sciences
2020
University of Chinese Academy of Sciences
2020
Sepsis is a fatal disease with high rate of morbidity and mortality, during which acute lung injury the earliest most serious complication. Injury pulmonary microvascular endothelial cells (PMVECs) induced by excessive inflammation plays an important role in sepsis injury. This study meant to explore protective effect mechanism ADSCs exosomes on PMVECs injury.We successfully isolated exosomes, characteristic were confirmed. reduced inflammatory response ROS accumulation cell PMVECs. Besides,...
The inner region of solid tumors is found to be high-pressure, hypoxic, and immunosuppressive, providing a breeding ground for tumor aggressiveness metastasis. While intratumoral accumulation nanomedicines combined with immunomodulation would significantly enhance therapeutic efficacy, such potential challenged by the compressed environment distinct heterogeneity bulk. By using an apoptotic body (AB) as carrier, we develop effective universal nanomedicine delivery system long-lasting...
Previous translational studies implicate plasma extracellular microRNA-30d (miR-30d) as a biomarker in left ventricular remodeling and clinical outcome heart failure (HF) patients, although precise mechanisms remain obscure.
Abstract Molecular profiling of protein markers on small extracellular vesicles (sEVs) is a promising strategy for the precise detection and classification ovarian cancers. However, this challenging owing to lack simple practical methods. In work, using an aptamer‐based nanoflow cytometry (nFCM) strategy, rapid method molecular multiple sEVs was developed. The can be easily labeled with aptamer probes then rapidly profiled by nFCM. Seven cancer‐associated markers, including CA125, STIP1,...
Exocytosis and retrieval of synaptic vesicles (SVs) are vital steps during neurotransmitter propagation between neurons. Visualization this dynamics SVs is significant for elucidating the mechanisms underlying transmission but remains challenging without an efficient, reliable, biocompatible labeling method. In work, we developed pH-responsive ratiometric DNA tetrahedral nanoprobes (pHadtnps) that could specifically label recycling with high stability effective background suppression. On...
We propose an aptamer-tethered DNA nanofirecracker probe that realizes molecular recognition-activatable disassembly of the nanostructure for imaging target molecules in living cells. The design principle offers a new paradigm to develop nucleic acid nanocircuits live-cell study and manipulation.
Abstract Molecular profiling of protein markers on small extracellular vesicles (sEVs) is a promising strategy for the precise detection and classification ovarian cancers. However, this challenging owing to lack simple practical methods. In work, using an aptamer‐based nanoflow cytometry (nFCM) strategy, rapid method molecular multiple sEVs was developed. The can be easily labeled with aptamer probes then rapidly profiled by nFCM. Seven cancer‐associated markers, including CA125, STIP1,...