A5103148545- Plant Gene Expression Analysis
- Plant Molecular Biology Research
- Botanical Research and Applications
- Carcinogens and Genotoxicity Assessment
- Pesticide Residue Analysis and Safety
- Agriculture, Soil, Plant Science
- Plant Virus Research Studies
- Phytochemicals and Antioxidant Activities
- Plant Reproductive Biology
- Cassava research and cyanide
- Topic Modeling
- Food Science and Nutritional Studies
- Insect-Plant Interactions and Control
- Phytochemistry and biological activity of medicinal plants
- Machine Learning and Data Classification
- Korean Urban and Social Studies
- Marine and coastal ecosystems
- S100 Proteins and Annexins
- Pelvic floor disorders treatments
- Coenzyme Q10 studies and effects
- Digital Transformation in Law
- Legal and Policy Issues
- Chemotherapy-induced organ toxicity mitigation
- Animal testing and alternatives
- Transgenic Plants and Applications
University of Wisconsin–Madison
2024
Korea Institute of Toxicology
2024
Inje University Haeundae Paik Hospital
2024
Seoul National University
2019-2023
Daejeon St. Mary's Hospital
2019
Catholic University of Korea
2019
Yonsei University
2019
Korea National Institute of Health
2018
Korea Disease Control and Prevention Agency
2018
National Academy of Agricultural Science
2012
Abstract Synthetic biology provides emerging tools to produce valuable compounds in plant hosts as sustainable chemical production platforms. However, little is known about how supply and utilization of precursors coordinated at the interface primary specialized metabolism, limiting our ability efficiently high levels target metabolites plants. L-Tyrosine an aromatic amino acid precursor diverse natural products including betalain pigments, which are used major food red colorants more...
The production of reactive oxygen species (ROS) by cisplatin is one the major mechanisms cisplatin-induced cytotoxicity. We examined preventive effect α-lipoic acid (LA) on toxicity via its antioxidant effects in vitro and ex vivo culture systems. To elucidate mechanism activity LA, NRF2 was inhibited using siRNA, change LA characterized. MTT assays showed that safe at concentrations up to 0.5 mM HEI-OC1 cells had a protective against Intracellular ROS rapidly increased for 48 h. However,...
Colistimethate sodium (CMS) nebulization is associated with reduced systemic toxicity compared to intravenous injection, potentially enhanced clinical efficacy. This study aimed assess the pharmacokinetic (PK) properties of colistin during low-dose CMS in patients ventilator-associated pneumonia (VAP) caused by carbapenem-resistant Acinetobacter baumannii. A nonlinear mixed-effects modeling approach was applied develop population PK models for both epithelial lining fluid (ELF) and plasma....
The present study aimed to monitor the levels of selected salivary biomarkers during development and treatment periodontitis evaluate their ability identify in dogs.A total 15 beagle dogs were divided into a control group (no ligature), 1 (ligature on six teeth), 2 12 teeth). experimental periods consisted 8 weeks induction 4 treatment. Clinical measurements sampling saliva performed every weeks. S100A8, S100A9, S100A8/A9, matrix metalloproteinase (MMP)-9 measured by enzyme-linked...
Nevus depigmentosus (ND) is a congenital, non-progressive, hypopigmented lesion that usually stable throughout an affected individual's lifetime.The clinical features of vitiligo are similar to those ND, but the two diseases have different treatment responses and prognoses.We report here on rare case was coexistent with ND.Both conditions were treated narrow-band UVB.An 11-year-old boy presented distinct types lesions, one forehead other his back.The first patch leukotrichia, it incidentally...
To provide the anatomy of puboprostatic ligament and related structures to save urogenital competence after prostatectomy.Pelvic areas 31 adult cadavers were dissected figure out shape, number, location ligaments.The was most important support structure between pubic bone prostate gland. Puboprostatic ligaments bilaterally single (61.3%), double (19.4%), or mixed (19.4%). Ligaments mostly I-shaped (53.8%). If had extra attachment from arcuate line, λ-shaped (36.3%), Y-shaped (8.8%). In one...
<title>Abstract</title> The Ames test is used worldwide to initially screen the mutagenic potential of new chemicals. In standard test, <italic>S. typhimurium</italic>strains (TA100, TA98, TA1535, and TA1537) <italic>Escherichia coli</italic> (WP2uvrA) are treated with substances with/without cytochrome P450s (CYPs)-induced rat S9 fractions for identifying mutagens pro mutagens. However, many show completely different toxicity patterns depending on whether liver fraction belongs rats or...
The Ames test is used worldwide to initially screen the mutagenic potential of new chemicals. In standard test, S. typhimurium strains (TA100, TA98, TA1535, and TA1537) Escherichia coli (WP2uvrA) are treated with substances with/without cytochrome P450s (CYPs)-induced rat S9 fractions for identifying mutagens pro-mutagens. However, many show completely different toxicity patterns depending on whether liver fraction belongs rats or humans. natural product Polygoni Multiflori Radix (PMR) can...
Abstract Amino acid transporters play crucial roles in plant nitrogen metabolism but also defense responses. AAT Rhg1 , an apparent amino transporter encoded by Glyma . 18g022400 ( Rhg1-GmAAT ) at the soybean locus, contributes to resistance cyst nematode (SCN), although planta function of remains elusive. In this study we discovered that overexpression roots enhances betalain pigment synthesis driven a RUBY transgene cassette, potentially through its activity affecting tyrosine level and...
Department of Chemistry, Kwangwoon University, Seoul 139-701, KoreaReceived September 30, 2002Key Words : Microcystin, Monoclonal antibody, CyanobacteriaMicrocystins are a family cyclic polypeptides producedby different species cyanobacteria (blue-green algae),which can form blooms in lakes and water reservoirs.
Prompting has gained tremendous attention as an efficient method for the adaptation of large-scale language models.However, prompts often act against human intuition and report unstable performances, which motivated methods that automatically find effective prompts.One popular approach is gradient-based search, iteratively updates a (randomly) initialized prompt towards optimal one with guide gradients.We propose novel regularization method, CoRe, tuning techniques, guides to produce task...
최근 농경지의 급격한 감소와 더불어 도시화, 경지정리, 도로공사 및 혁신도시 건설 등으로 토지이용의 변화가 심하게 발생되고 있다. 특히, 토지이용 변화심화지역인 경기도 고양시, 충청남도 천안시, 강원도 원주시를 대상으로 토지 이용변화실태, 토양특성변화양상, 토양도수정내용 기업도시 편입되는 지역의 토양환경분석을 하였다. 이에 대한 결과를 요약하면 다음과 같다. 1. 우리나라의 경지면적 (2011년)은 2009년대비 17.3 ha가 감소되었다. 논의 경우 24.2 감소되었으나, 밭의 경우에는 7.0 증가하였다. 2. 면적 감소사유로는 논밭전환 (20.7 ha) > 공공시설 (3.2) <TEX>${\geq}$</TEX> 건물건축 유휴지 (1.3) 기타 (0.9) 순이며, 밭 면적의 증가원인은 개간 (4.5) 복구 (0.3) 순이었다. 논밭전환의 이유는 논농사에서 농가소득이 높은 밭작물 내지 시설작물로 전환하는 것으로 생각된다. 3. 토지이용변화가 심한 해당시군의 농경지감소 (논,...
Soybean (Glycine max (L.) Merr.) is an important source of vegetable oil and high protein. Use soybean meal by the food industry increasing, but severely limiting dietary choices quality life food-allergic individuals. Gly m Bd 30K (P34) known as main seed allergens in soybean-sensitive patients. The objective this work was to determine molecular basis low mutation P34 design marker for selection causative mutations wild homozygous, heterozygous mutant homozygous. We developed a co-dominant...
Abstract The key regulatory gene CaAN2 encodes an R2R3 MYB transcription factor that regulates anthocyanin biosynthesis in various tissues pepper ( Capsicum annuum ). However, is not expressed certain accessions showing fruit-specific accumulation. In this study, we identified the novel locus CaAN3 as a regulator of biosynthesis, using F 2 population derived from hybrid cultivar with purple immature fruits and segregating for . We extracted total RNA, assembled two RNA pools according to...
Hyper-parameter optimization is crucial for pushing the accuracy of a deep learning model to its limits. However, hyper-parameter job, referred as study, involves numerous trials training using different knobs, and therefore very computation-heavy, typically taking hours days finish. We observe that issued from algorithms often share common sequence prefixes. Based on this observation, we propose Hippo, system reuses computation across reduce overall amount significantly. Instead treating...
본 연구는 효소보충치료(ERT)를 받고 있는 뮤코다당증 환자들의 경험을 파악하기 위한 목적으로 수행되었다. 질적 연구방법을 적용하였고, 효소보충치료를 7명의 성인환자를 대상으로. 2018년 7월 1일 부터 22일까지 심층 인터뷰를 통해 자료를 수집하였다. 수집된 개별 면담 자료는 필사하여 귀납적 내용 분석 방법으로 분석하였다. 연구결과, 환자의 경험은 최종 4개의 범주(효소보충치료를 통한 신체‧심리적 변화, 효소보충치료라는 계속되는 터널, 치료에 대한 현실 받아들이기, 조심스러운 희망)와 15개의 하위 범주로 도출되었다. 따라서, 의사 및 간호사는 이러한 고려하여 돌봄 을 제공해야 할 것이고, 정부 또한 신체적 증상 뿐 아니라 효소보충치료로 인한 어려움을 고려한 실질적 인 정책을 마련할 필요가 있다. 희귀질환인 확인하였다는 점에서 의의가
2021년 4월 유럽연합 집행위원회가 야심차게 발표한 인공지능법안은 약 1년이 지난 지금도 제정 과정에 있다. 집행위원회는 인공지능법안에 일반정보보호규정(GDPR)과 유사한 조항을 많이 도입하면서도 한편으로는 3년간의 GDPR 집행 경험을 바탕으로 인공지능법안의 강력한 집행을 뒷받침할 수 있는 거버넌스 조항들을 추가하였다. 이러한 통해 우리는 효과적이고 일관된 시행을 위해 인공지능위원회를 총괄하고, 이 회원국에 맡겨져 국내 규제에 대한 관리ㆍ감독을 구체화하려 했다고 추정할 다만 집행위원회의 이런 시도는 1년 뒤인 2022년 유럽의회와 이사회가 보고서의 수정안에서 대부분 수정되었다. 수정안에는 인공지능위원회의 독립성이 명시되어 있고, 위원장도 아닌 인공지능위원회 회원 중 한 명을 선출하는 쪽으로 바뀌었기 때문이다. 또한 수정안은 위원회의 장악력을 약화시키는 대신 업무 내용을 추가하여 역할과 권한을 공고히 하고, GDPR과 더 도입해 인공지능위원회가 회원국의 감독기관 사이를...