A5001793650- Pelvic floor disorders treatments
- Anorectal Disease Treatments and Outcomes
- Diverticular Disease and Complications
- Colorectal Cancer Surgical Treatments
- Circadian rhythm and melatonin
- Chemotherapy-induced cardiotoxicity and mitigation
- Vascular Procedures and Complications
- Sexual function and dysfunction studies
- Urinary Bladder and Prostate Research
- Congenital gastrointestinal and neural anomalies
- Coronary Interventions and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- Hernia repair and management
- Cardiac, Anesthesia and Surgical Outcomes
- Gastrointestinal motility and disorders
- Central Venous Catheters and Hemodialysis
- Cancer-related cognitive impairment studies
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Colorectal and Anal Carcinomas
University of Milan
2023-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2023-2024
Ospedale Maggiore
2023-2024
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2023-2024
Fondazione Poliambulanza Istituto Ospedaliero
2024
Università Cattolica del Sacro Cuore
2007-2016
Catholic University of America
2011-2013
Abstract Background Various injectable bulking agents have been used for the treatment of faecal incontinence (FI). However, encouraging early results are not maintained over time. This study aimed to assess short- and medium-term a new agent FI. Methods The Gatekeeper™ prosthesis comprises thin solid polyacrylonitrile cylinder that becomes thicker, shorter softer within 24 h after implantation. Fourteen patients with FI underwent under local anaesthesia. Four prostheses were implanted in...
The surgical treatment of a complex anal fistula remains controversial, although 'sphincter-saving' operations are desirable. Gore Bio-A® Fistula Plug is new bioprosthetic plug that has been proposed for the fistula. This study reports preliminary data following implantation this plug.Eleven patients with underwent insertion Plugs. disc diameter and number tubes in were adapted to allow accommodation into submucosal pocket, excess trimmed. During follow-up period, clinical physical...
A variety of therapeutic approaches are available for faecal incontinence. Implantation Gatekeeper prostheses is a new promising option. The primary endpoint this prospective observational multicentre study was to assess the clinical efficacy implantation in patients with Secondary endpoints included assessment patients' quality life, and feasibility safety implantation.Patients incontinence, either intact sphincters or internal anal sphincter lesions extending less than 60° circumference,...
Abstract Background Dearterialization should reduce arterial overflow to haemorrhoids. The purpose of this study was assess the topography haemorrhoidal arteries. Methods Fifty patients with disease were studied. Using endorectal ultrasonography, six sectors identified within lower rectal circumference. Starting from highest level (6 cm above anorectal junction), same procedure repeated every 1 until lowest reached (1 junction). Colour duplex imaging examinations arteries related wall...
Transanal haemorrhoidal dearterialization (THD® Doppler) is a surgical procedure involving Doppler-guided ligation of arteries to reduce arterial flow. With proximal dearterialization, achieved by introducing the proctoscope completely into anal canal and lower rectum. In present study, distal (DDD) performed in 2 cm Immediate short-term results were evaluated.One hundred patients with bleeding haemorrhoids, or without muco-haemorrhoidal prolapse, underwent THD® Doppler procedure, using DDD...
Abstract Introduction A new artificial anal sphincter, SphinKeeper TM , was devised with the aim to treat fecal incontinence (FI) by implanting specifically designed self-expandable prostheses into intersphincteric space. Preliminary data concerning procedure feasibility and prosthesis localization at 3 months are presented. Methods in native state dehydrated, thin, solid cylinder (length 29 mm, diameter mm), changing their (shorter—length 23 thicker—diameter 7 mm—and softer, shape memory)...
The pathogenesis of cryptoglandular anal fistula (AF) is still under debate. Tissue inflammation could play a primary role. pathological process epithelial mesenchymal transition (EMT) might be involved but has never been investigated.In prospective pilot study, 12 patients with an AF had fistulectomy. excised track was divided into proximal (intrasphincteric) and distal (extrasphincteric) parts which were subjected to standard histopathological examination. cytokines IL-8 IL-1beta analysed...
Aim The effect of transanal haemorrhoidal dearterialization (THD) on continence and anorectal physiology has not yet been demonstrated. Method Twenty patients suffering from 3rd degree haemorrhoids were enrolled underwent THD, including both mucopexy. Clinical assessment, manometry, rectal volumetry endoanal ultrasound performed preoperatively at 6 months postoperatively. Results Postoperatively two six had transient pain tenesmus, respectively. No patient reported faecal urgency or minor...
Antecubital access for right heart catheterization (RHC) is a widespread technique, even though there need to clarify if are differences and significant advantages compared proximal vein access. To pursue this issue, we retrospectively identified patients who underwent RHC in our clinic over 7 year period (between January 2015 December 2022). We revised demographic, anthropometric, procedural data, including the fluoroscopy time, radiation exposure, use of guidewires. The presence any...
Abstract Aortic stenosis (AS) is the most prevalent valvular heart disease in developed countries, associated with reduced survival if severe AS remains untreated. Recent reports note unfavorable outcomes moderate (mAS) patients, challenging optimal intervention timing. Variations pathophysiology linked to sex differences, involving hormones, activation of renin–angiotensin–aldosterone system, and dysregulation collagen synthesis, have been observed. Yet, limited data exists on sex–specific...